Strain Name:
C57BL/6J-MtgxR1747Btlr/Mmmh
Stock Number:
039779-MU
Citation ID:
RRID:MMRRC_039779-MU
Other Names:
R1747 (G1), C57BL/6J-MtgxR1747Btlr
Major Collection:

Strain Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPRA, GC-A, NPR-A, guanylyl cyclase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22774
Homologene: 32075
Htr5b
Name: 5-hydroxytryptamine (serotonin) receptor 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15564
Homologene: 74951
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: InsP6, 1200016D08Rik, Ihpk1, InsP6k1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27399
Homologene: 56602
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Diaph3
Name: diaphanous related formin 3
Synonyms: p134MDia2, mDia2, 4930417P13Rik, Drf3, Diap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Exoc6
Name: exocyst complex component 6
Synonyms: msec15, 4833405E05Rik, Sec15, Sec15l1, hbd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228790
Homologene: 9098
Dennd4c
Name: DENN/MADD domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329877
Homologene: 23057
Stag1
Name: stromal antigen 1
Synonyms: SA-1, Scc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20842
Homologene: 21191
Prom1
Name: prominin 1
Synonyms: AC133, CD133, Prom, 4932416E19Rik, Prom-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Nog
Name: noggin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18121
HGNC: HGNC:7866
Homologene: 3979
Add3
Name: adducin 3 (gamma)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 27360
VEGA: 19
HGNC: HGNC:245
Homologene: 40893
Glg1
Name: golgi apparatus protein 1
Synonyms: ESL-1, CFR, MG-160, MG160, CFR-1, Selel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Pgs1
Name: phosphatidylglycerophosphate synthase 1
Synonyms: 2610019F11Rik, 4933424M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74451
Homologene: 5467
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99470
Homologene: 26431
Thyn1
Name: thymocyte nuclear protein 1
Synonyms: D730042P09Rik, Thy28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77862
VEGA: 9
Homologene: 8575
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Skiv2l
Name: superkiller viralicidic activity 2-like (S. cerevisiae)
Synonyms: Ski2w, 4930534J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108077
Homologene: 123971
Ern2
Name: endoplasmic reticulum (ER) to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26918
Homologene: 22687
Arhgef28
Name: Rho guanine nucleotide exchange factor (GEF) 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Scnn1g
Name: sodium channel, nonvoltage-gated 1 gamma
Synonyms: ENaC gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20278
Homologene: 20280
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Prdm14
Name: PR domain containing 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 383491
Homologene: 11556
Klhl6
Name: kelch-like 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239743
Homologene: 15603
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cpne8
Name: copine VIII
Synonyms: 1200003E11Rik, 1500031E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66871
Homologene: 12049
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 207618
Homologene: 52304
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213043
Homologene: 84622
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106205
Homologene: 8563
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 103967
Homologene: 22906
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620928
Homologene: 115466
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231238
Homologene: 9054
Gm4736
Name: predicted gene 4736
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100502592
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: 1110035E02Rik, 1700007L07Rik, hea, fsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225049
Homologene: 12515
Ap1m2
Name: adaptor protein complex AP-1, mu 2 subunit
Synonyms: [m]1B, mu1B, D9Ertd818e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11768
VEGA: 9
HGNC: HGNC:558
Homologene: 55906
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Ifi44
Name: interferon-induced protein 44
Synonyms: p44, MTAP44, A430056A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99899
Homologene: 4683
Smg8
Name: SMG8 nonsense mediated mRNA decay factor
Synonyms: 1200011M11Rik, smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74133
Homologene: 32393
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041449
Homologene: 135775
1700029H14Rik
Name: RIKEN cDNA 1700029H14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66501
Homologene: 41638
Hhla1
Name: HERV-H LTR-associating 1
Synonyms: F930104E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 654498
HGNC: HGNC:4904
Homologene: 129987
Ak3
Name: adenylate kinase 3
Synonyms: AK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56248
Homologene: 21744
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73430
Psmd8
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Synonyms: 6720456J22Rik, C76433
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57296
HGNC: HGNC:9566
Homologene: 37686
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5830484A20Rik, 5031415C07Rik, Ifi75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Wnt10b
Name: wingless-type MMTV integration site family, member 10B
Synonyms: Wnt12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22410
VEGA: 15
Homologene: 20721
Slc10a5
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 5
Synonyms: LOC241877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241877
Homologene: 78106
Or8k21
Name: olfactory receptor family 8 subfamily K member 21
Synonyms: GA_x6K02T2Q125-47793414-47792471, MOR187-4, Olfr1053-ps1, Olfr1053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257974
Homologene: 74197
Vmn1r236
Name: vomeronasal 1 receptor 236
Synonyms: V1rf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171235
Or7e173
Name: olfactory receptor family 7 subfamily E member 173
Synonyms: GA_x6K02T2PVTD-13768406-13767468, MOR145-5, Olfr866
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258551
HGNC: HGNC:8396
Homologene: 133687
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Armc7
Name: armadillo repeat containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276905
Homologene: 11603
Csn1s2b
Name: casein alpha s2-like B
Synonyms: Csne, Csnd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12992
Homologene: 49221
Scrt2
Name: scratch family zinc finger 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545474
Homologene: 99867
Btbd8
Name: BTB (POZ) domain containing 8
Synonyms: EG627196, Gm16115, A830010M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100503185
VEGA: 5
Homologene: 82388
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 13,122,403 bp
  • A to C, chromosome 1 at 34,160,709 bp
  • A to T, chromosome 1 at 58,339,592 bp
  • C to G, chromosome 1 at 85,589,118 bp
  • A to T, chromosome 1 at 121,527,918 bp
  • G to A, chromosome 1 at 162,313,584 bp
  • G to C, chromosome 2 at 31,457,985 bp
  • T to C, chromosome 2 at 76,878,516 bp
  • G to A, chromosome 2 at 86,314,867 bp
  • T to C, chromosome 2 at 91,492,621 bp
  • C to T, chromosome 2 at 152,093,718 bp
  • C to A, chromosome 2 at 153,393,454 bp
  • G to T, chromosome 3 at 10,335,391 bp
  • C to T, chromosome 3 at 90,458,669 bp
  • T to C, chromosome 3 at 104,034,173 bp
  • T to A, chromosome 3 at 151,749,285 bp
  • T to C, chromosome 4 at 86,807,438 bp
  • C to G, chromosome 5 at 6,770,217 bp
  • C to T, chromosome 5 at 44,007,031 bp
  • C to T, chromosome 5 at 53,145,545 bp
  • T to C, chromosome 5 at 87,816,670 bp
  • T to C, chromosome 5 at 107,451,999 bp
  • A to G, chromosome 5 at 146,104,758 bp
  • G to A, chromosome 6 at 132,115,670 bp
  • T to A, chromosome 7 at 10,047,678 bp
  • T to C, chromosome 7 at 13,337,730 bp
  • G to T, chromosome 7 at 27,911,081 bp
  • A to G, chromosome 7 at 29,174,762 bp
  • A to T, chromosome 7 at 85,858,167 bp
  • A to T, chromosome 7 at 121,760,463 bp
  • C to A, chromosome 7 at 122,173,819 bp
  • T to A, chromosome 7 at 122,173,820 bp
  • C to T, chromosome 8 at 13,558,814 bp
  • G to A, chromosome 8 at 111,197,673 bp
  • A to C, chromosome 9 at 20,027,317 bp
  • A to G, chromosome 9 at 21,305,686 bp
  • A to C, chromosome 9 at 27,005,213 bp
  • G to A, chromosome 9 at 91,384,146 bp
  • T to A, chromosome 9 at 100,888,300 bp
  • G to A, chromosome 9 at 108,040,996 bp
  • A to G, chromosome 10 at 28,354,692 bp
  • T to C, chromosome 11 at 86,707,081 bp
  • A to G, chromosome 11 at 87,085,303 bp
  • T to A, chromosome 11 at 89,301,582 bp
  • G to A, chromosome 11 at 115,488,757 bp
  • A to G, chromosome 11 at 118,001,631 bp
  • G to A, chromosome 12 at 13,335,898 bp
  • T to C, chromosome 13 at 13,757,422 bp
  • T to C, chromosome 13 at 97,936,824 bp
  • T to G, chromosome 14 at 74,706,153 bp
  • T to C, chromosome 14 at 87,073,337 bp
  • A to G, chromosome 15 at 65,941,853 bp
  • G to A, chromosome 15 at 90,584,915 bp
  • A to G, chromosome 15 at 98,774,333 bp
  • A to G, chromosome 16 at 11,145,253 bp
  • G to T, chromosome 16 at 15,785,901 bp
  • T to A, chromosome 16 at 19,947,028 bp
  • A to G, chromosome 17 at 12,924,808 bp
  • C to T, chromosome 17 at 21,286,917 bp
  • G to T, chromosome 17 at 34,847,806 bp
  • C to A, chromosome 17 at 67,901,309 bp
  • A to G, chromosome 17 at 87,307,015 bp
  • G to T, chromosome 19 at 29,022,861 bp
  • T to A, chromosome 19 at 37,639,769 bp
  • A to G, chromosome 19 at 53,242,550 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1747 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039779-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.