Strain Name:
C57BL/6J-MtgxR2850Btlr/Mmmh
Stock Number:
040443-MU
Citation ID:
RRID:MMRRC_040443-MU
Other Names:
R2850 (G1), C57BL/6J-MtgxR2850Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Gnb5
Name: guanine nucleotide binding protein (G protein), beta 5
Synonyms: G beta 5, Gbeta5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14697
VEGA: 9
HGNC: HGNC:4401
Homologene: 40714
Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: Nedd4-1, Nedd4, Nedd4a, E430025J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Th
Name: tyrosine hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21823
Homologene: 307
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Itch
Name: itchy, E3 ubiquitin protein ligase
Synonyms: 6720481N21Rik, C230047C07Rik, 8030492O04Rik, AIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16396
Homologene: 88442
Rbpms
Name: RNA binding protein gene with multiple splicing
Synonyms: hermes, 2700019M19Rik, 2010300K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19663
Homologene: 38238
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66771
Homologene: 5971
Fbxo22
Name: F-box protein 22
Synonyms: 1600016C16Rik, 0610033L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71999
Homologene: 12433
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: 5830450F21Rik, D7Ertd629e, 2010203C02Rik, MOF, Myst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67773
Homologene: 41676
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233833
Homologene: 41399
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319817
Homologene: 28276
Kif11
Name: kinesin family member 11
Synonyms: Eg5, Knsl1, Kifl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229096
Homologene: 34991
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235469
Homologene: 17151
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22083
Homologene: 40668
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Anxa6
Name: annexin A6
Synonyms: Camb, Anx6, AnxVI, Annexin VI, Cabm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Clk1
Name: CDC-like kinase 1
Synonyms: STY, Clk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12747
HGNC: HGNC:2068
Homologene: 101535
Ifrd2
Name: interferon-related developmental regulator 2
Synonyms: SKMc15, 1810034A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15983
HGNC: HGNC:5457
Homologene: 21341
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 5730465C04Rik, 1700087N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 81910
Homologene: 68138
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216742
Homologene: 28173
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234076
Homologene: 32376
Zp2
Name: zona pellucida glycoprotein 2
Synonyms: Zp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22787
Homologene: 48194
Cubn
Name: cubilin (intrinsic factor-cobalamin receptor)
Synonyms: D2Wsu88e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Rpgrip1l
Name: Rpgrip1-like
Synonyms: Ftm, 1700047E16Rik, fantom, Nphp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244585
Homologene: 18296
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: CNG6, CCNC2, Cngbeta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329278
Homologene: 18634
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269514
Homologene: 8128
Actn2
Name: actinin alpha 2
Synonyms: 1110008F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11472
HGNC: HGNC:164
Homologene: 31016
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, alpha(1B), Cav2.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53419
Homologene: 4804
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
Synonyms: p55pik, p55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18710
HGNC: HGNC:8981
Homologene: 2690
Bank1
Name: B cell scaffold protein with ankyrin repeats 1
Synonyms: A530094C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242248
Homologene: 9926
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 208890
Homologene: 13770
Ube2j1
Name: ubiquitin-conjugating enzyme E2J 1
Synonyms: 0710008M05Rik, Ncube, Ubc6p, 1110030I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56228
Homologene: 41090
Stard6
Name: StAR-related lipid transfer (START) domain containing 6
Synonyms: 4833424I06Rik, 4933429L05Rik, 1700011K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170461
Homologene: 12578
Gpank1
Name: G patch domain and ankyrin repeats 1
Synonyms: G5, D17H6S54E, Bat4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81845
Homologene: 13035
Zfp354c
Name: zinc finger protein 354C
Synonyms: Kid3, AJ18, 5330421P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30944
Homologene: 56606
Olfr1454
Name: olfactory receptor 1454
Synonyms: GA_x6K02T2RE5P-3390804-3391727, MOR202-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258687
Homologene: 120159
Mrps26
Name: mitochondrial ribosomal protein S26
Synonyms: Rpms13, MRP-S26, MRP-S13, GI008
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99045
Homologene: 12778
Hbq1b
Name: hemoglobin, theta 1B
Synonyms: F830116E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544763
HGNC: HGNC:4833
Homologene: 3895
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
E330020D12Rik
Name: Riken cDNA E330020D12 gene
Synonyms: Gm6648
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 626058
AC225888.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Gtf3c6
Name: general transcription factor IIIC, polypeptide 6, alpha
Synonyms: 2410016F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67371
VEGA: 10
Homologene: 12121
Prr9
Name: proline rich 9
Synonyms: A030004J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109314
Homologene: 130379
Trem3
Name: triggering receptor expressed on myeloid cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58218
VEGA: 17
Homologene: 87012
Hdx
Name: highly divergent homeobox
Synonyms: D030011N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245596
Homologene: 16963
Cypt3
Name: cysteine-rich perinuclear theca 3
Synonyms: Ckt1r1, 1700006H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69361
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,509,076 bp
  • A to G, chromosome 1 at 58,412,279 bp
  • A to G, chromosome 1 at 153,406,590 bp
  • T to C, chromosome 1 at 160,139,287 bp
  • G to A, chromosome 2 at 13,322,953 bp
  • C to T, chromosome 2 at 24,761,788 bp
  • A to T, chromosome 2 at 37,377,415 bp
  • T to C, chromosome 2 at 130,565,047 bp
  • C to T, chromosome 2 at 143,949,349 bp
  • A to C, chromosome 2 at 155,202,221 bp
  • T to C, chromosome 3 at 16,203,818 bp
  • A to T, chromosome 3 at 92,123,169 bp
  • A to T, chromosome 3 at 136,284,266 bp
  • T to A, chromosome 4 at 14,593,806 bp
  • T to C, chromosome 4 at 19,415,690 bp
  • T to C, chromosome 4 at 22,403,624 bp
  • T to A, chromosome 4 at 33,049,696 bp
  • A to G, chromosome 4 at 116,270,784 bp
  • T to C, chromosome 4 at 126,443,075 bp
  • T to A, chromosome 5 at 32,293,224 bp
  • A to G, chromosome 5 at 72,304,955 bp
  • G to A, chromosome 5 at 76,919,375 bp
  • T to C, chromosome 6 at 85,621,299 bp
  • C to A, chromosome 6 at 85,667,963 bp
  • C to T, chromosome 7 at 111,053,446 bp
  • T to C, chromosome 7 at 120,138,306 bp
  • G to A, chromosome 7 at 123,179,800 bp
  • T to C, chromosome 7 at 127,915,366 bp
  • G to A, chromosome 7 at 142,894,075 bp
  • A to G, chromosome 8 at 13,295,024 bp
  • G to T, chromosome 8 at 33,834,377 bp
  • G to T, chromosome 8 at 68,899,512 bp
  • T to C, chromosome 8 at 91,289,611 bp
  • A to G, chromosome 8 at 107,293,860 bp
  • T to A, chromosome 8 at 109,623,990 bp
  • T to C, chromosome 9 at 55,223,415 bp
  • A to G, chromosome 9 at 72,312,089 bp
  • C to T, chromosome 9 at 72,725,074 bp
  • A to T, chromosome 9 at 75,327,229 bp
  • T to C, chromosome 9 at 107,591,709 bp
  • C to T, chromosome 10 at 21,000,593 bp
  • T to C, chromosome 10 at 40,254,258 bp
  • G to A, chromosome 11 at 32,287,191 bp
  • G to A, chromosome 11 at 50,815,331 bp
  • A to T, chromosome 11 at 54,502,677 bp
  • T to A, chromosome 11 at 55,011,026 bp
  • G to A, chromosome 11 at 60,438,574 bp
  • A to G, chromosome 11 at 67,256,509 bp
  • A to T, chromosome 11 at 75,451,172 bp
  • T to A, chromosome 13 at 12,275,179 bp
  • T to C, chromosome 15 at 103,752,082 bp
  • A to G, chromosome 16 at 33,269,642 bp
  • A to G, chromosome 16 at 90,774,256 bp
  • A to G, chromosome 17 at 35,124,581 bp
  • C to A, chromosome 17 at 48,249,641 bp
  • A to G, chromosome 17 at 78,954,596 bp
  • T to A, chromosome 18 at 70,483,451 bp
  • T to C, chromosome 19 at 13,063,570 bp
  • T to A, chromosome 19 at 18,792,090 bp
  • C to A, chromosome 19 at 37,409,493 bp
  • T to C, chromosome X at 111,593,023 bp
  • T to A, chromosome X at 153,559,278 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2850 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040443-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.