Strain Name:
C57BL/6J-MtgxR2874Btlr/Mmmh
Stock Number:
040462-MU
Citation ID:
RRID:MMRRC_040462-MU
Other Names:
R2874 (G1), C57BL/6J-MtgxR2874Btlr
Major Collection:

Gene Information

Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: fatty acid transport protein 4, FATP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 26569
Homologene: 68437
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234094
Homologene: 22827
Glo1
Name: glyoxalase 1
Synonyms: Glo1-r, 2510049H23Rik, 0610009E22Rik, 1110008E19Rik, Qglo, Glo-1, Glo1-s, Glo-1r, Glo-1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 109801
VEGA: 17
HGNC: HGNC:4323
Homologene: 4880
St5
Name: suppression of tumorigenicity 5
Synonyms: 2010004M01Rik, 2610305K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76954
Homologene: 3951
Prps1
Name: phosphoribosyl pyrophosphate synthetase 1
Synonyms: Prps-1, 2310010D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 19139
HGNC: HGNC:9462
Homologene: 68275
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: Adprt1, 5830444G22Rik, parp-1, Adprp, sPARP-1, PARP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: AD3, GRAM domain, BUB2-like protein 1, HBLP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 54610
Homologene: 31421
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21745
VEGA: 14
Homologene: 5157
Klf8
Name: Kruppel-like factor 8
Synonyms: A830097P10Rik, ZNF74, BKLF3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 245671
HGNC: HGNC:6351
Homologene: 68549
St7
Name: suppression of tumorigenicity 7
Synonyms: Fam4a2, TSG7, SEN4, HELG, 9430001H04Rik, RAY1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 64213
Homologene: 10185
Stx3
Name: syntaxin 3
Synonyms: syntaxin 3A, Syn-3, syntaxin 3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20908
Homologene: 80191
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 170935
Homologene: 15781
Plxna3
Name: plexin A3
Synonyms: Plxn4, Plxa3, PlexA3, SEX, Plxn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 18846
HGNC: HGNC:9101
Homologene: 7481
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68750
Homologene: 2218
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, N1, Motch A, 9930111A19Rik, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Ext2
Name: exostoses (multiple) 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Mtm1
Name: X-linked myotubular myopathy gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 17772
HGNC: HGNC:7448
Homologene: 37279
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 5730419H05Rik, 1200013I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74132
Homologene: 14036
Noc4l
Name: NOC4 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100608
Homologene: 40545
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106794
VEGA: 17
Homologene: 56267
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Itpr5, Ip3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Vwa7
Name: von Willebrand factor A domain containing 7
Synonyms: D17H6S56E-3, G7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 27762
Homologene: 11895
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ggct
Name: gamma-glutamyl cyclotransferase
Synonyms: Ggc, Gctg, A030007L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 110175
Homologene: 11437
Kpna7
Name: karyopherin alpha 7 (importin alpha 8)
Synonyms: importin alpha 2, LOC381686
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381686
Homologene: 73467
Ttc25
Name: tetratricopeptide repeat domain 25
Synonyms: 4933404O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74407
Homologene: 12860
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: RalGDS, Rgds, Gnds
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Clstn3
Name: calsyntenin 3
Synonyms: CSTN3, alcadein-beta, Cst-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232370
Homologene: 22836
2210016F16Rik
Name: RIKEN cDNA 2210016F16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 70153
Homologene: 13005
Fscb
Name: fibrous sheath CABYR binding protein
Synonyms: EG623046
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 623046
VEGA: 12
Homologene: 136275
Zfp53
Name: zinc finger protein 53
Synonyms: KRAZ1, Zfp-53, zfas8, Zfp118, D030067O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 24132
VEGA: 17
Homologene: 135946
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, CBF2, Cbf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12607
VEGA: 17
Homologene: 4210
Ankrd42
Name: ankyrin repeat domain 42
Synonyms: 4933417L02Rik, Ikbn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 73845
Homologene: 23652
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Msh5
Name: mutS homolog 5
Synonyms: Mut5, G7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Gm10717
Name: predicted gene 10717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620697
Homologene: 115466
Sgk2
Name: serum/glucocorticoid regulated kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27219
Homologene: 8446
Spsb4
Name: splA/ryanodine receptor domain and SOCS box containing 4
Synonyms: Ssb4, D030068E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 211949
Homologene: 25315
4931428F04Rik
Name: RIKEN cDNA 4931428F04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 74356
Homologene: 47588
Itgax
Name: integrin alpha X
Synonyms: Cd11c, CD11C (p150) alpha polypeptide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Frmpd4
Name: FERM and PDZ domain containing 4
Synonyms: PKAP1, LOC237234, Preso, Preso1, Pdzd10, Pdzk10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 333605
Homologene: 45843
Rasl12
Name: RAS-like, family 12
Synonyms: 4631404I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 70784
VEGA: 9
Homologene: 9565
Gm813
Name: predicted gene 813
Synonyms: LOC385656, LOC328695
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 328695
VEGA: 16
Slc25a23
Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Synonyms: SCaMC-3, 2310067G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66972
Homologene: 11467
Olfr419
Name: olfactory receptor 419
Synonyms: GA_x6K02T2P20D-20891507-20892448, MOR267-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 258710
Homologene: 72017
Cd6
Name: CD6 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 12511
HGNC: HGNC:1691
Homologene: 4893
Psmb8
Name: proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms: Lmp7, Lmp-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 16913
HGNC: HGNC:9545
Homologene: 56499
C030034I22Rik
Name: RIKEN cDNA C030034I22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 77533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 14,887,620 bp
  • A to G, chromosome 1 at 39,405,317 bp
  • T to C, chromosome 1 at 174,250,526 bp
  • A to G, chromosome 1 at 180,573,665 bp
  • A to G, chromosome 2 at 26,460,235 bp
  • A to G, chromosome 2 at 28,548,769 bp
  • T to C, chromosome 2 at 29,809,652 bp
  • A to G, chromosome 2 at 40,851,693 bp
  • A to G, chromosome 2 at 93,739,686 bp
  • A to G, chromosome 2 at 162,994,529 bp
  • A to G, chromosome 5 at 110,649,103 bp
  • C to A, chromosome 5 at 143,357,929 bp
  • T to C, chromosome 5 at 144,993,935 bp
  • T to C, chromosome 5 at 146,210,405 bp
  • C to T, chromosome 6 at 17,819,277 bp
  • G to T, chromosome 6 at 54,992,774 bp
  • T to A, chromosome 6 at 124,438,335 bp
  • T to C, chromosome 6 at 146,426,498 bp
  • A to G, chromosome 7 at 7,290,521 bp
  • A to C, chromosome 7 at 85,233,626 bp
  • T to C, chromosome 7 at 92,605,358 bp
  • A to T, chromosome 7 at 109,557,430 bp
  • A to T, chromosome 7 at 128,133,828 bp
  • T to C, chromosome 8 at 14,975,093 bp
  • A to G, chromosome 8 at 14,975,666 bp
  • G to A, chromosome 8 at 71,334,337 bp
  • A to G, chromosome 8 at 105,282,032 bp
  • A to G, chromosome 9 at 3,025,532 bp
  • A to G, chromosome 9 at 65,408,323 bp
  • A to T, chromosome 9 at 79,699,549 bp
  • G to T, chromosome 9 at 96,996,018 bp
  • T to A, chromosome 11 at 100,551,031 bp
  • T to C, chromosome 12 at 64,473,436 bp
  • T to C, chromosome 13 at 37,916,508 bp
  • T to A, chromosome 13 at 58,382,570 bp
  • A to G, chromosome 14 at 50,850,650 bp
  • A to T, chromosome 16 at 58,613,979 bp
  • A to T, chromosome 17 at 21,508,078 bp
  • T to C, chromosome 17 at 30,596,473 bp
  • T to C, chromosome 17 at 34,200,170 bp
  • G to A, chromosome 17 at 35,021,242 bp
  • G to T, chromosome 17 at 35,029,181 bp
  • T to C, chromosome 17 at 57,053,847 bp
  • T to A, chromosome 17 at 69,418,111 bp
  • A to T, chromosome 17 at 78,932,103 bp
  • A to T, chromosome 17 at 80,251,376 bp
  • A to G, chromosome 19 at 10,794,626 bp
  • A to T, chromosome 19 at 11,789,574 bp
  • T to C, chromosome X at 71,296,362 bp
  • T to A, chromosome X at 74,339,396 bp
  • C to T, chromosome X at 140,471,994 bp
  • A to T, chromosome X at 153,382,682 bp
  • A to T, chromosome X at 167,477,247 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2874 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040462-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.