Strain Name:
C57BL/6J-MtgxR3692Btlr/Mmmh
Stock Number:
040687-MU
Citation ID:
RRID:MMRRC_040687-MU
Other Names:
R3692 (G1), C57BL/6J-MtgxR3692Btlr
Major Collection:

Strain Information

St3gal5
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms: 3S-T, ST3Gal V, [a]2, GM3 synthase, GM3-specific sialytransferase, Siat9, mST3Gal V
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20454
Homologene: 2893
Calca
Name: calcitonin/calcitonin-related polypeptide, alpha
Synonyms: CA, Calc, Ct, Cgrp, CT, Ctn, alpha CGRP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12310
Homologene: 88337
Rgs11
Name: regulator of G-protein signaling 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50782
HGNC: HGNC:9993
Homologene: 77719
Glrx3
Name: glutaredoxin 3
Synonyms: Txnl2, PICOT, PKC interacting cousin of thioredoxin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Cdk8
Name: cyclin dependent kinase 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: D17Ertd808e, 2610025H06Rik, PNUTS
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229681
Homologene: 14910
Tox
Name: thymocyte selection-associated high mobility group box
Synonyms: 1700007F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 252838
Homologene: 8822
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Chsy1
Name: chondroitin sulfate synthase 1
Synonyms: skt
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269941
Homologene: 8950
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Pcdhb16
Name: protocadherin beta 16
Synonyms: PcdhbP, Pcdhb8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93887
Homologene: 99843
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Dennd6b
Name: DENN domain containing 6B
Synonyms: 1700027J05Rik, Fam116b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69440
VEGA: 15
Homologene: 57065
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Aff3
Name: AF4/FMR2 family, member 3
Synonyms: LAF-4, Laf4, 3222402O04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16764
HGNC: HGNC:6473
Homologene: 1718
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: CD120b, TNF-R75, TNF-R-II, TNFR80, TNFBR, TNFRII, p75 TNFR, TNF-R2, Tnfr2, TNF-alphaR2, p75, TNFalpha-R2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21938
Homologene: 829
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: 4832426G23Rik, Myhs-p, Myhsp, MyHC-pn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Gm4934
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ifi208
Name: interferon activated gene 208
Synonyms: E430029J22Rik, Pyr-rv1, Pydc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Krt34
Name: keratin 34
Synonyms: Krt1-4, 4733401E01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16672
HGNC: HGNC:6452
Homologene: 31083
Mat1a
Name: methionine adenosyltransferase 1A
Synonyms: MAT, SAMS1, AdoMet, Ams, MATA1, SAMS
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11720
VEGA: 14
HGNC: HGNC:6903
Homologene: 68057
Or4a69
Name: olfactory receptor family 4 subfamily A member 69
Synonyms: Olfr1241, MOR231-14, GA_x6K02T2Q125-50926215-50925271
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258447
Homologene: 74067
Or14c46
Name: olfactory receptor family 14 subfamily C member 46
Synonyms: MOR227-6P, GA_x6K02T2NHDJ-9838699-9839697, Olfr310
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258222
Homologene: 128066
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381066
VEGA: 17
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Fut10
Name: fucosyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 171167
Homologene: 32790
Noxred1
Name: NADP+ dependent oxidoreductase domain containing 1
Synonyms: 4933437F05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71275
VEGA: 12
Homologene: 51388
Mtif2
Name: mitochondrial translational initiation factor 2
Synonyms: IF-2mt, 2410112O06Rik, 2310038D14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76784
HGNC: HGNC:7441
Homologene: 1840
Vmn1r236
Name: vomeronasal 1 receptor 236
Synonyms: V1rf4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171235
Nkx2-6
Name: NK2 homeobox 6
Synonyms: Tix, Nkx-2.6, Nkx2.6, tinman
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18092
Homologene: 22604
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Tekt4
Name: tektin 4
Synonyms: 1700010L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71840
Homologene: 25745
Tpbpa
Name: trophoblast specific protein alpha
Synonyms: Tpbp, Tb-1, 4311, clone 4311, Tb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21984
VEGA: 13
Homologene: 49203
Rfk
Name: riboflavin kinase
Synonyms: ATP:riboflavin 5'-phosphotransferase, flavokinase, 0610038L10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54391
Homologene: 115690
Adam1a
Name: a disintegrin and metallopeptidase domain 1a
Synonyms: PH-30 alpha, Ftna, fertilin alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280668
HGNC: HGNC:187
Homologene: 73803
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,555,129 bp
  • G to A, chromosome 1 at 38,335,876 bp
  • T to C, chromosome 1 at 173,682,872 bp
  • T to A, chromosome 2 at 89,482,896 bp
  • T to C, chromosome 3 at 104,891,554 bp
  • T to C, chromosome 4 at 6,697,535 bp
  • G to T, chromosome 4 at 145,227,522 bp
  • A to T, chromosome 5 at 75,189,287 bp
  • A to G, chromosome 5 at 86,822,667 bp
  • T to C, chromosome 5 at 121,519,322 bp
  • C to T, chromosome 5 at 146,283,668 bp
  • T to A, chromosome 6 at 4,510,710 bp
  • T to C, chromosome 6 at 72,149,029 bp
  • T to A, chromosome 7 at 25,288,913 bp
  • T to A, chromosome 7 at 51,590,579 bp
  • T to A, chromosome 7 at 66,171,253 bp
  • T to A, chromosome 7 at 86,269,495 bp
  • T to C, chromosome 7 at 114,634,561 bp
  • T to C, chromosome 7 at 137,459,117 bp
  • T to A, chromosome 8 at 31,236,020 bp
  • A to T, chromosome 11 at 29,540,718 bp
  • A to G, chromosome 11 at 67,301,918 bp
  • A to G, chromosome 11 at 78,269,509 bp
  • A to G, chromosome 11 at 100,039,031 bp
  • G to A, chromosome 12 at 87,233,466 bp
  • T to C, chromosome 13 at 59,717,891 bp
  • T to A, chromosome 13 at 60,940,013 bp
  • A to G, chromosome 13 at 81,524,600 bp
  • A to G, chromosome 13 at 107,726,541 bp
  • A to G, chromosome 14 at 41,121,381 bp
  • T to C, chromosome 14 at 57,691,541 bp
  • T to A, chromosome 14 at 62,404,627 bp
  • T to C, chromosome 14 at 69,172,027 bp
  • A to G, chromosome 15 at 89,186,827 bp
  • A to G, chromosome 17 at 21,286,806 bp
  • T to G, chromosome 17 at 21,587,576 bp
  • T to A, chromosome 17 at 25,248,014 bp
  • T to C, chromosome 17 at 25,475,727 bp
  • C to T, chromosome 17 at 26,204,328 bp
  • A to G, chromosome 17 at 35,930,868 bp
  • C to A, chromosome 18 at 37,478,287 bp
  • C to A, chromosome 19 at 17,399,470 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3692 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040687-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.