Strain Name:
C57BL/6J-MtgxR3842Btlr/Mmmh
Stock Number:
040782-MU
Citation ID:
RRID:MMRRC_040782-MU
Other Names:
R3842 (G1), C57BL/6J-MtgxR3842Btlr
Major Collection:

Gene Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: 1110061A24Rik, RII(alpha)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Ncam2
Name: neural cell adhesion molecule 2
Synonyms: Ocam, RNCAM, R4B12 antigen, Ncam-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17968
HGNC: HGNC:7657
Homologene: 3336
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Topors
Name: topoisomerase I binding, arginine/serine-rich
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 106021
Homologene: 4237
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: seladin-1, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, 2310076D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Tasp1
Name: taspase, threonine aspartase 1
Synonyms: 4930485D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75812
Homologene: 9795
Nemf
Name: nuclear export mediator factor
Synonyms: 1500011I12Rik, Sdccag1, 4933405E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Fabp3
Name: fatty acid binding protein 3, muscle and heart
Synonyms: Fabph1, Fabph-4, Fabph4, Mdgi, Fabp3, H-FABP, Fabph-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14077
HGNC: HGNC:3557
Homologene: 68379
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: 9330188B09Rik, D630001M17Rik, 4921513O20Rik, cI-46, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, Pmscl2, PM-Scl, p2, RRP6, p4, p3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Naa40
Name: N(alpha)-acetyltransferase 40, NatD catalytic subunit
Synonyms: 4931433E08Rik, Nat11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70999
VEGA: 19
Homologene: 41588
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: AZ-1, Lcn7, Arg1, androgen-regulated gene 1, 1110021J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94242
Homologene: 41472
Ttn
Name: titin
Synonyms: 2310036G12Rik, mdm, 1100001C23Rik, shru, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, L56, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fbxo30
Name: F-box protein 30
Synonyms: 1700026A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71865
Homologene: 12959
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242259
Homologene: 72094
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: CaMK II, Camkg, 5930429P18Rik, Ca2+/calmodulin-dependent protein kinase II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
Grik3
Name: glutamate receptor, ionotropic, kainate 3
Synonyms: Glur7, Glur-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14807
HGNC: HGNC:4581
Homologene: 73901
Olfr1335
Name: olfactory receptor 1335
Synonyms: MOR259-12, GA_x6K02T2QD9B-18723799-18724749, MOR259-5, GA_x6K02T2QD9B-18726774-18727577, Olfr1334-ps1, Olfr1335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 435804
Homologene: 138635
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, 2310010P21Rik, DXImx49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223809
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Itgbl1
Name: integrin, beta-like 1
Synonyms: B930011D01Rik, with EGF-like repeat domains
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Tgfbrap1
Name: transforming growth factor, beta receptor associated protein 1
Synonyms: 3110018K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73122
Homologene: 3141
Bmp2k
Name: BMP2 inducible kinase
Synonyms: BIKE, 4933417M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140780
Homologene: 34134
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Olfr705
Name: olfactory receptor 705
Synonyms: GA_x6K02T2PBJ9-9256348-9255398, MOR283-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259034
Homologene: 128075
Hyal2
Name: hyaluronoglucosaminidase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15587
HGNC: HGNC:5321
Homologene: 7776
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666348
VEGA: 15
Homologene: 40940
Olfr825
Name: olfactory receptor 825
Synonyms: MOR210-1, GA_x6K02T2PULF-11834065-11833103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258672
Homologene: 121503
Nkain1
Name: Na+/K+ transporting ATPase interacting 1
Synonyms: 2810426C15Rik, 2610200G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67149
Homologene: 11566
Gtf3c6
Name: general transcription factor IIIC, polypeptide 6, alpha
Synonyms: 2410016F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67371
VEGA: 10
Homologene: 12121
Hmgb2
Name: high mobility group box 2
Synonyms: HMG-2, Hmg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 97165
HGNC: HGNC:5000
Homologene: 37582
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 43,059,154 bp
  • A to G, chromosome 2 at 76,789,619 bp
  • T to C, chromosome 2 at 76,850,303 bp
  • T to A, chromosome 2 at 139,951,501 bp
  • G to A, chromosome 3 at 129,697,793 bp
  • T to C, chromosome 3 at 154,261,394 bp
  • C to T, chromosome 4 at 40,262,123 bp
  • G to T, chromosome 4 at 106,585,805 bp
  • A to G, chromosome 4 at 118,809,255 bp
  • T to C, chromosome 4 at 125,693,954 bp
  • G to T, chromosome 4 at 130,167,311 bp
  • C to T, chromosome 4 at 130,312,387 bp
  • T to A, chromosome 4 at 130,537,296 bp
  • T to A, chromosome 4 at 148,563,865 bp
  • A to G, chromosome 5 at 97,087,151 bp
  • A to G, chromosome 5 at 138,167,035 bp
  • G to A, chromosome 7 at 106,874,095 bp
  • T to C, chromosome 7 at 114,526,867 bp
  • T to A, chromosome 8 at 57,513,354 bp
  • T to C, chromosome 9 at 107,572,121 bp
  • A to G, chromosome 9 at 108,728,268 bp
  • A to G, chromosome 10 at 11,290,112 bp
  • A to T, chromosome 10 at 40,254,321 bp
  • G to A, chromosome 10 at 130,162,901 bp
  • C to T, chromosome 12 at 69,331,949 bp
  • T to C, chromosome 13 at 42,157,727 bp
  • T to C, chromosome 13 at 70,738,891 bp
  • C to T, chromosome 14 at 8,251,543 bp
  • T to C, chromosome 14 at 20,764,898 bp
  • A to G, chromosome 14 at 123,840,565 bp
  • C to T, chromosome 15 at 76,002,650 bp
  • A to G, chromosome 15 at 77,717,589 bp
  • C to A, chromosome 15 at 91,755,916 bp
  • T to A, chromosome 15 at 91,860,262 bp
  • A to G, chromosome 16 at 30,260,518 bp
  • A to G, chromosome 16 at 81,434,810 bp
  • T to C, chromosome 17 at 71,045,624 bp
  • A to T, chromosome 19 at 7,229,809 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3842 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040782-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.