Strain Name:
C57BL/6J-MtgxR3776Btlr/Mmmh
Stock Number:
040874-MU
Citation ID:
RRID:MMRRC_040874-MU
Other Names:
R3776 (G1), C57BL/6J-MtgxR3776Btlr
Major Collection:

Gene Information

Slc26a5
Name: solute carrier family 26, member 5
Synonyms: Pres, prestin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80979
HGNC: HGNC:9359
Homologene: 69472
Pdgfc
Name: platelet-derived growth factor, C polypeptide
Synonyms: PDGF-C, 1110064L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54635
HGNC: HGNC:8801
Homologene: 9423
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: Pcaf, A930006P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Cyt28, Gpr56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98732
Homologene: 40842
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Kif23
Name: kinesin family member 23
Synonyms: MKLP-1, C87313, CHO1, MKLP1, 3110001D19Rik, Knsl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Mxi1
Name: MAX interactor 1, dimerization protein
Synonyms: Mad2, bHLHc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 17859
VEGA: 19
HGNC: HGNC:7534
Homologene: 4351
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: CD45, Ly-5, T200, Lyt-4, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Ubxn11
Name: UBX domain protein 11
Synonyms: Soci, 4930506L07Rik, Ubxd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67586
Homologene: 12159
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: 2810442I22Rik, PMCA1, E130111D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Fbxl5
Name: F-box and leucine-rich repeat protein 5
Synonyms: Fir4, Fbl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242960
Homologene: 8129
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Crispld2
Name: cysteine-rich secretory protein LCCL domain containing 2
Synonyms: coffeecrisp, 1810049K24Rik, Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78892
Homologene: 41792
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233552
Homologene: 32741
Plod1
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms: lysyl hydroxylase 1, 2410042F05Rik, LH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18822
HGNC: HGNC:9081
Homologene: 256
Nup160
Name: nucleoporin 160
Synonyms: Gtl1-13, 2810011M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 59015
Homologene: 32509
Glt1d1
Name: glycosyltransferase 1 domain containing 1
Synonyms: 5730455A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319804
Homologene: 16965
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: MTP, 1810043K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, LTRPC3, 6330504P12Rik, B930001P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, D86 mRNA, PKHDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329482
Homologene: 79722
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Acer1
Name: alkaline ceramidase 1
Synonyms: 2310024P18Rik, Cer1, Asah3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171168
VEGA: 17
Homologene: 15853
Dll1
Name: delta like canonical Notch ligand 1
Synonyms: Delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13388
HGNC: HGNC:2908
Homologene: 4104
Ednra
Name: endothelin receptor type A
Synonyms: Gpcr10, Mhdaaea1, AEA001, ET-AR, ETa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13617
HGNC: HGNC:3179
Homologene: 1478
Klra2
Name: killer cell lectin-like receptor, subfamily A, member 2
Synonyms: Ly49b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16633
Homologene: 133782
Fads2b
Name: fatty acid desaturase 2B
Synonyms: 4833423E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228151
Homologene: 105643
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, Vwa6, 1110001D15Rik, Dvwa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68553
Homologene: 130754
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18080
Homologene: 40632
Pgbd1
Name: piggyBac transposable element derived 1
Synonyms: 4921509E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319207
Homologene: 130030
Rnf19a
Name: ring finger protein 19A
Synonyms: XYbp, XY body protein, Dorfin, Rnf19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 30945
VEGA: 15
Homologene: 8501
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Slc25a19
Name: solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Synonyms: 2900089E13Rik, DNC, TPC, MUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67283
Homologene: 5982
Gm6990
Name: predicted pseudogene 6990
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 629643
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353025
Homologene: 72278
Krt32
Name: keratin 32
Synonyms: Krt1-2, mHa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16670
HGNC: HGNC:6449
Homologene: 68246
Olfr1234
Name: olfactory receptor 1234
Synonyms: GA_x6K02T2Q125-50805620-50804676, MOR231-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258975
Homologene: 128156
Eif6
Name: eukaryotic translation initiation factor 6
Synonyms: Itgb4bp, p27BBP, imc-415, eIF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16418
HGNC: HGNC:6159
Homologene: 7135
Zg16
Name: zymogen granule protein 16
Synonyms: 1810010M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69036
Homologene: 12296
Hhex
Name: hematopoietically expressed homeobox
Synonyms: Hhex-rs2, Hex, Hex1, Prhx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15242
HGNC: HGNC:4901
Homologene: 31110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 138,064,773 bp
  • T to C, chromosome 1 at 185,277,205 bp
  • T to C, chromosome 2 at 85,518,415 bp
  • A to T, chromosome 2 at 89,362,764 bp
  • G to T, chromosome 2 at 90,722,076 bp
  • C to A, chromosome 2 at 106,372,393 bp
  • T to A, chromosome 2 at 155,826,376 bp
  • G to A, chromosome 2 at 181,240,389 bp
  • A to G, chromosome 3 at 81,141,551 bp
  • T to C, chromosome 3 at 138,114,263 bp
  • C to T, chromosome 4 at 134,108,294 bp
  • A to G, chromosome 4 at 147,931,277 bp
  • C to T, chromosome 5 at 21,814,890 bp
  • A to G, chromosome 5 at 43,758,276 bp
  • T to A, chromosome 5 at 127,694,311 bp
  • A to T, chromosome 6 at 131,242,963 bp
  • G to A, chromosome 7 at 99,454,572 bp
  • T to A, chromosome 7 at 127,050,532 bp
  • A to G, chromosome 8 at 77,675,095 bp
  • C to T, chromosome 8 at 95,009,655 bp
  • T to C, chromosome 8 at 120,029,266 bp
  • G to A, chromosome 9 at 61,924,992 bp
  • G to A, chromosome 9 at 106,051,701 bp
  • A to G, chromosome 10 at 93,045,100 bp
  • CTTTTT to CTTTTTT, chromosome 10 at 98,979,869 bp
  • A to G, chromosome 10 at 112,204,041 bp
  • A to G, chromosome 11 at 100,088,121 bp
  • G to T, chromosome 11 at 102,023,367 bp
  • T to G, chromosome 11 at 104,515,437 bp
  • G to T, chromosome 11 at 106,779,284 bp
  • A to G, chromosome 11 at 115,615,459 bp
  • C to T, chromosome 11 at 117,723,529 bp
  • G to T, chromosome 12 at 70,038,682 bp
  • G to A, chromosome 12 at 100,947,179 bp
  • A to G, chromosome 13 at 21,428,373 bp
  • T to C, chromosome 14 at 115,370,060 bp
  • T to A, chromosome 15 at 36,265,912 bp
  • G to A, chromosome 15 at 44,514,975 bp
  • T to C, chromosome 17 at 15,368,524 bp
  • A to G, chromosome 17 at 53,567,581 bp
  • C to T, chromosome 17 at 56,955,111 bp
  • G to A, chromosome 18 at 57,277,105 bp
  • A to G, chromosome 18 at 61,081,920 bp
  • T to C, chromosome 19 at 22,978,602 bp
  • A to T, chromosome 19 at 37,437,270 bp
  • C to A, chromosome 19 at 53,371,729 bp
  • A to C, chromosome 19 at 56,755,078 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3776 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040874-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.