Strain Name:
C57BL/6J-MtgxR3925Btlr/Mmmh
Stock Number:
040916-MU
Citation ID:
RRID:MMRRC_040916-MU
Other Names:
R3925 (G1), C57BL/6J-MtgxR3925Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22288
VEGA: 10
Homologene: 21398
Eno1
Name: enolase 1, alpha non-neuron
Synonyms: MBP-1, Eno-1, 2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13806
HGNC: HGNC:3350
Homologene: 134343
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 170750
Homologene: 6424
Crct1
Name: cysteine-rich C-terminal 1
Synonyms: 2300002G24Rik, Nice-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74175
Prim2
Name: DNA primase, p58 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19076
HGNC: HGNC:9370
Homologene: 731
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, p325, 4832420A03Rik, C030033M12Rik, Hbxap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233532
Homologene: 41142
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Zfp953
Name: zinc finger protein 953
Synonyms: E130120F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 629016
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Eif4e
Name: eukaryotic translation initiation factor 4E
Synonyms: If4e, eIF-4E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13684
HGNC: HGNC:3287
Homologene: 123817
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 665700
Homologene: 90772
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Olfr1102
Name: olfactory receptor 1102
Synonyms: MOR179-4, GA_x6K02T2Q125-48487992-48488966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228228
Homologene: 88426
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Itgal
Name: integrin alpha L
Synonyms: Cd11a, LFA-1, Ly-21, Ly-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Folr1
Name: folate receptor 1 (adult)
Synonyms: folate-binding protein 1, FBP1, Folbp-1, folate receptor [a], Folbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14275
HGNC: HGNC:3791
Homologene: 7322
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 76390
Homologene: 88945
Onecut2
Name: one cut domain, family member 2
Synonyms: Oc2, OC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Trp53rkb
Name: transformation related protein 53 regulating kinase B
Synonyms: 5630401H01Rik, 4933401B08Rik, PRPK, Trp53rk, mNori-2p, Nori-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 76367
Homologene: 6042
Cdkl1
Name: cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms: 4933411O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, Wdr96, D19Ertd652e, 4930463G05Rik, 4632415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100048534
Homologene: 36425
Pycr1
Name: pyrroline-5-carboxylate reductase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 209027
HGNC: HGNC:9721
Homologene: 56002
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 93835
VEGA: 12
Homologene: 12804
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: ePAB, 1810053B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381404
Homologene: 77989
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: Gpr103, AQ27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229214
Homologene: 18865
C230029F24Rik
Name: RIKEN cDNA C230029F24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 442837
Selenoi
Name: selenoprotein I
Synonyms: D5Wsu178e, C79563, 4933402G07Rik, Ept1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 28042
Homologene: 100935
Sept8
Name: septin 8
Synonyms: Sepl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20362
Homologene: 57205
Nr2e3
Name: nuclear receptor subfamily 2, group E, member 3
Synonyms: photoreceptor-specific nuclear receptor, RNR, Pnr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 23958
HGNC: HGNC:7974
Homologene: 84397
Olfr224
Name: olfactory receptor 224
Synonyms: Olfr327-ps1, MOR275-3, GA_x6K02T2NKPP-858022-858862, GA_x6K02T00261-652-347, MOR275-10_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258198
Homologene: 133015
Asl
Name: argininosuccinate lyase
Synonyms: 2510006M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109900
HGNC: HGNC:746
Homologene: 32
Cops9
Name: COP9 signalosome subunit 9
Synonyms: 1110002M09Rik, Myeov2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66915
Homologene: 82250
Ms4a2
Name: membrane-spanning 4-domains, subfamily A, member 2
Synonyms: Fcrbeta, Fcer1b, Fce1b, FcRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14126
HGNC: HGNC:7316
Homologene: 112
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 33,533,299 bp
  • AGAAAG to A, chromosome 1 at 49,310,929 bp
  • A to G, chromosome 1 at 92,637,406 bp
  • G to A, chromosome 2 at 31,453,157 bp
  • A to G, chromosome 2 at 87,002,374 bp
  • T to A, chromosome 2 at 164,027,676 bp
  • A to G, chromosome 2 at 166,795,472 bp
  • T to C, chromosome 3 at 36,221,923 bp
  • C to A, chromosome 3 at 93,014,707 bp
  • G to A, chromosome 3 at 138,555,437 bp
  • T to C, chromosome 4 at 150,239,568 bp
  • T to A, chromosome 5 at 30,256,088 bp
  • A to G, chromosome 5 at 130,019,869 bp
  • GCG to GCGACGGCGACG, chromosome 7 at 97,579,907 bp
  • T to C, chromosome 7 at 101,859,246 bp
  • A to T, chromosome 7 at 127,324,537 bp
  • C to T, chromosome 9 at 59,948,433 bp
  • C to T, chromosome 10 at 12,698,042 bp
  • T to A, chromosome 11 at 23,343,640 bp
  • T to G, chromosome 11 at 53,531,981 bp
  • T to A, chromosome 11 at 58,566,826 bp
  • T to C, chromosome 11 at 73,711,124 bp
  • C to T, chromosome 11 at 84,040,899 bp
  • T to C, chromosome 11 at 120,642,135 bp
  • G to T, chromosome 12 at 69,756,599 bp
  • T to C, chromosome 12 at 111,275,680 bp
  • T to A, chromosome 13 at 67,347,938 bp
  • G to A, chromosome 13 at 81,578,772 bp
  • A to T, chromosome 14 at 96,346,880 bp
  • A to G, chromosome 18 at 64,341,520 bp
  • A to G, chromosome 19 at 11,618,948 bp
  • T to C, chromosome 19 at 47,797,116 bp
  • T to C, chromosome 19 at 52,991,697 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3925 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040916-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.