Strain Name:
C57BL/6J-MtgxR4298Btlr/Mmmh
Stock Number:
041086-MU
Citation ID:
RRID:MMRRC_041086-MU
Other Names:
R4298 (G1), C57BL/6J-MtgxR4298Btlr
Major Collection:

Gene Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF200, NF-H, NEFH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Dsk9, Nf-1, Mhdadsk9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Taf1d
Name: TATA-box binding protein associated factor, RNA polymerase I, D
Synonyms: Josd3, TAF(I)41, TAFI41, 4930553M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75316
VEGA: 9
Homologene: 11472
Rack1
Name: receptor for activated C kinase 1
Synonyms: Gnb2l1, Gnb2-rs1, p205, GB-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14694
HGNC: HGNC:4399
Homologene: 4446
Dusp12
Name: dual specificity phosphatase 12
Synonyms: ESTM36, 1190004O14Rik, T-DSP4, LMW-DSP4, mVH1, VH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 80915
HGNC: HGNC:3067
Homologene: 5238
Ctdp1
Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68014
Homologene: 32381
Epcam
Name: epithelial cell adhesion molecule
Synonyms: Tacstd1, Ep-CAM, panepithelial glycoprotein 314, EpCAM1, GA733-2, CD326, EGP-2, TROP1, Ly74, Egp314, EpCAM, gp40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17075
VEGA: 17
Homologene: 1764
Cct7
Name: chaperonin containing Tcp1, subunit 7 (eta)
Synonyms: Ccth, Cctz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12468
HGNC: HGNC:1622
Homologene: 4694
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, CHMP family, member 7, 6330407G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105513
VEGA: 14
Homologene: 14613
Stk39
Name: serine/threonine kinase 39
Synonyms: RF005, Rnl5, SPAK, DCHT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 53416
Homologene: 22739
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 2900054P12Rik, 1700012P13Rik, Gcap14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 72972
Homologene: 10367
Ebf3
Name: early B cell factor 3
Synonyms: O/E-2, Olf-1/EBF-like 2, 3110018A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13593
Homologene: 56472
Glipr1l1
Name: GLI pathogenesis-related 1 like 1
Synonyms: 1700011E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 69286
VEGA: 10
Homologene: 83452
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230676
Homologene: 49413
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 64297
Homologene: 9435
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: arrestin 1, A930001K18Rik, visual arrestin 1, Arr1, rod arrestin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20215
Homologene: 455
F2
Name: coagulation factor II
Synonyms: Cf2, FII, Cf-2, prothrombin, thrombin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14061
HGNC: HGNC:3535
Homologene: 426
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Nyap2
Name: neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
Synonyms: 9430031J16Rik, Jr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241134
Homologene: 18239
Sbk3
Name: SH3 domain binding kinase family, member 3
Synonyms: LOC381835, Gm1078
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381835
Homologene: 82595
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: V2Rp5, EG619697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 619697
Homologene: 86604
Cyp4a10
Name: cytochrome P450, family 4, subfamily a, polypeptide 10
Synonyms: RP1, Msp-3, Cyp4a, D4Rp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13117
HGNC: HGNC:2642
Homologene: 128044
Abcc12
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244562
Homologene: 57211
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 320083
Homologene: 110776
Erich6
Name: glutamate rich 6
Synonyms: Fam194a, 4932431H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 545527
Homologene: 65043
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320506
VEGA: 15
Homologene: 44696
Dsc3
Name: desmocollin 3
Synonyms: 5430426I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13507
VEGA: 18
HGNC: HGNC:3037
Homologene: 1462
Spata20
Name: spermatogenesis associated 20
Synonyms: Tisp78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217116
Homologene: 11264
Extl1
Name: exostosin-like glycosyltransferase 1
Synonyms: D430033M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56219
HGNC: HGNC:3515
Homologene: 3277
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: D1Ertd701e, 5730466A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 59014
Homologene: 41014
Olfr1263
Name: olfactory receptor 1263
Synonyms: GA_x6K02T2Q125-51447049-51447969, MOR234-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258790
Homologene: 45043
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: Gpr103, AQ27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229214
Homologene: 18865
Vmn2r12
Name: vomeronasal 2, receptor 12
Synonyms: Gm6769
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 627569
Homologene: 129606
Tnfrsf13b
Name: tumor necrosis factor receptor superfamily, member 13b
Synonyms: 1200009E08Rik, Taci
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 57916
Homologene: 49320
Pramef25
Name: PRAME family member 25
Synonyms: Gm13109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329984
Homologene: 83161
St3gal2
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 2
Synonyms: ST3GalII, Siat5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20444
Homologene: 5047
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240084
Homologene: 10396
Prdm11
Name: PR domain containing 11
Synonyms: 8030443D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100042784
Homologene: 82511
Mcpt4
Name: mast cell protease 4
Synonyms: Mcp4, myonase, MMCP-4, MMCP-4B, Mcp-4, MMCP-4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 17227
VEGA: 14
Homologene: 130645
Pdcd4
Name: programmed cell death 4
Synonyms: D19Ucla1, TIS, MA-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18569
VEGA: 19
HGNC: HGNC:8763
Homologene: 7879
Zdhhc4
Name: zinc finger, DHHC domain containing 4
Synonyms: 1810021D01Rik, 2900029I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72881
Homologene: 10006
Unc119
Name: unc-119 lipid binding chaperone
Synonyms: MRG4, Unc119h, UNC119, HRG4, Rtg4, Rg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22248
Homologene: 3778
Olfr268-ps1
Name: olfactory receptor 268, pseudogene 1
Synonyms: Gm13931, GA_x6K02T2N82Q-12713-13766, MOR245-17P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668825
Homologene: 138901
Gm16276
Name: predicted gene 16276
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 9,546,223 bp
  • A to T, chromosome 1 at 81,241,096 bp
  • G to C, chromosome 1 at 87,845,015 bp
  • G to A, chromosome 1 at 170,880,629 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • C to T, chromosome 2 at 68,390,940 bp
  • G to T, chromosome 2 at 76,724,050 bp
  • A to T, chromosome 2 at 90,015,649 bp
  • T to G, chromosome 2 at 91,629,320 bp
  • T to C, chromosome 2 at 92,993,383 bp
  • G to T, chromosome 2 at 111,844,444 bp
  • T to A, chromosome 3 at 36,189,554 bp
  • G to T, chromosome 3 at 58,624,291 bp
  • T to C, chromosome 4 at 115,532,692 bp
  • A to G, chromosome 4 at 118,365,406 bp
  • C to G, chromosome 4 at 121,054,258 bp
  • T to C, chromosome 4 at 134,357,658 bp
  • A to T, chromosome 4 at 143,949,143 bp
  • A to C, chromosome 5 at 21,920,487 bp
  • C to A, chromosome 5 at 109,091,964 bp
  • A to G, chromosome 5 at 143,324,242 bp
  • T to A, chromosome 6 at 85,468,173 bp
  • T to A, chromosome 7 at 4,969,980 bp
  • C to T, chromosome 7 at 7,296,738 bp
  • G to A, chromosome 7 at 118,984,214 bp
  • C to T, chromosome 7 at 137,225,229 bp
  • T to C, chromosome 8 at 86,531,525 bp
  • T to C, chromosome 8 at 110,962,359 bp
  • T to C, chromosome 9 at 15,308,643 bp
  • A to G, chromosome 9 at 64,155,162 bp
  • T to C, chromosome 9 at 109,446,557 bp
  • A to T, chromosome 10 at 112,062,347 bp
  • A to G, chromosome 11 at 4,940,066 bp
  • T to C, chromosome 11 at 48,801,626 bp
  • C to G, chromosome 11 at 61,140,817 bp
  • A to G, chromosome 11 at 78,348,122 bp
  • A to T, chromosome 11 at 79,384,244 bp
  • G to A, chromosome 11 at 94,483,088 bp
  • A to G, chromosome 13 at 13,634,887 bp
  • T to A, chromosome 14 at 36,890,380 bp
  • A to T, chromosome 14 at 56,060,987 bp
  • A to T, chromosome 14 at 69,719,201 bp
  • G to A, chromosome 15 at 9,165,795 bp
  • A to T, chromosome 15 at 53,345,125 bp
  • T to A, chromosome 17 at 23,401,827 bp
  • C to A, chromosome 17 at 35,520,978 bp
  • C to T, chromosome 17 at 56,019,173 bp
  • T to C, chromosome 17 at 87,640,534 bp
  • A to T, chromosome 18 at 19,980,754 bp
  • A to T, chromosome 18 at 80,449,957 bp
  • C to A, chromosome 19 at 53,919,661 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4298 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041086-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.