Strain Name:
C57BL/6J-MtgxR4164Btlr/Mmmh
Stock Number:
041638-MU
Citation ID:
RRID:MMRRC_041638-MU
Other Names:
R4164 (G1), C57BL/6J-MtgxR4164Btlr
Major Collection:

Gene Information

Ighm
Name: immunoglobulin heavy constant mu
Synonyms: Ig mu, Igh6, Igh-M, muH, IgM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16019
HGNC: HGNC:5541
Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Prkcd
Name: protein kinase C, delta
Synonyms: PKCdelta, PKC[d], Pkcd, D14Ertd420e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18753
HGNC: HGNC:9399
Homologene: 55963
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Ifi203
Name: interferon activated gene 203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15950
Homologene: 115929
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 245945
Homologene: 36932
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68732
Homologene: 9757
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Ell
Name: elongation factor RNA polymerase II
Synonyms: Men, Ell1, eleven-nineteen lysine-rich leukemia gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13716
Homologene: 4762
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Dennd4c
Name: DENN/MADD domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329877
Homologene: 23057
Lamb2
Name: laminin, beta 2
Synonyms: Lamb-2, Lams, npht
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72416
Homologene: 32695
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: chromatin remodeling factor, 8030453L17Rik, E430018P19Rik, KMT2H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107351
Homologene: 17706
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik, Olfaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235315
Homologene: 109357
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5c, Nav1.5, mH1, SkM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20271
Homologene: 22738
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Defb41
Name: defensin beta 41
Synonyms: 9230102D03Rik, Gm15386
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77673
Lrrc66
Name: leucine rich repeat containing 66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231296
Homologene: 51944
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216859
Homologene: 22835
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20678
Homologene: 21378
Cntn5
Name: contactin 5
Synonyms: LOC244683, NB-2, A830025P08Rik, 6720426O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Fam189a2
Name: family with sequence similarity 189, member A2
Synonyms: LOC381217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21897
Homologene: 20694
Spout1
Name: SPOUT domain containing methyltransferase 1
Synonyms: D2Wsu81e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227695
Homologene: 6704
Oas1c
Name: 2'-5' oligoadenylate synthetase 1C
Synonyms: Oasl5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 114643
HGNC: HGNC:8086
Homologene: 110815
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435916
Homologene: 135826
Mpp1
Name: membrane protein, palmitoylated
Synonyms: 55kDa, C130070C03Rik, erythrocyte protein p55, p55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17524
HGNC: HGNC:7219
Homologene: 1826
Ifi203-ps
Name: interferon activated gene 203, pseudogene
Synonyms: Gm16340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504287
Homologene: 115929
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 101113
Homologene: 43132
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68888
Homologene: 87422
Gm2223
Name: predicted pseudogene 2223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 100039419
Or8a1b
Name: olfactory receptor family 8 subfamily A member 1B
Synonyms: M72, MOR171-3, MOR171-3, GA_x6K02T2PVTD-31389446-31388517, Olfr160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80706
HGNC: HGNC:8469
Homologene: 12726
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 18,260,597 bp
  • A to G, chromosome 1 at 72,626,689 bp
  • A to T, chromosome 1 at 140,609,630 bp
  • A to G, chromosome 1 at 173,776,556 bp
  • A to T, chromosome 1 at 173,928,463 bp
  • C to T, chromosome 2 at 30,177,577 bp
  • T to C, chromosome 2 at 125,751,883 bp
  • T to C, chromosome 2 at 164,786,850 bp
  • A to G, chromosome 3 at 88,981,966 bp
  • C to A, chromosome 4 at 86,807,527 bp
  • A to G, chromosome 5 at 64,927,202 bp
  • A to G, chromosome 5 at 66,026,992 bp
  • T to A, chromosome 5 at 73,629,776 bp
  • T to C, chromosome 5 at 120,808,139 bp
  • T to A, chromosome 6 at 67,423,663 bp
  • C to T, chromosome 6 at 73,089,592 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • A to T, chromosome 6 at 123,729,738 bp
  • T to A, chromosome 6 at 144,116,480 bp
  • G to T, chromosome 8 at 70,581,573 bp
  • CAAAAA to CAAAA, chromosome 8 at 84,716,247 bp
  • A to G, chromosome 9 at 9,781,676 bp
  • T to G, chromosome 9 at 37,711,698 bp
  • G to A, chromosome 9 at 45,871,912 bp
  • T to A, chromosome 9 at 108,490,298 bp
  • T to C, chromosome 9 at 119,495,778 bp
  • A to G, chromosome 11 at 21,996,638 bp
  • C to T, chromosome 11 at 69,890,037 bp
  • T to A, chromosome 12 at 113,422,295 bp
  • G to A, chromosome 13 at 24,074,045 bp
  • A to T, chromosome 14 at 7,915,374 bp
  • A to G, chromosome 14 at 30,601,197 bp
  • T to C, chromosome 15 at 8,338,934 bp
  • T to A, chromosome 15 at 25,726,415 bp
  • T to C, chromosome 15 at 55,609,521 bp
  • A to C, chromosome 15 at 58,559,238 bp
  • T to C, chromosome 17 at 84,731,189 bp
  • G to A, chromosome 19 at 6,532,143 bp
  • T to C, chromosome 19 at 17,003,734 bp
  • G to A, chromosome 19 at 23,975,629 bp
  • C to T, chromosome 19 at 23,975,638 bp
  • A to G, chromosome 19 at 25,411,072 bp
  • C to T, chromosome X at 33,505,784 bp
  • T to A, chromosome X at 75,125,875 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4164 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041638-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.