Strain Name:
C57BL/6J-MtgxR5122Btlr/Mmmh
Stock Number:
042710-MU
Citation ID:
RRID:MMRRC_042710-MU
Other Names:
R5122 (G1), C57BL/6J-MtgxR5122Btlr
Major Collection:

Gene Information

Hyal1
Name: hyaluronoglucosaminidase 1
Synonyms: Hyal-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15586
HGNC: HGNC:5320
Homologene: 5277
Pofut2
Name: protein O-fucosyltransferase 2
Synonyms: FUT13, 2310011G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 80294
VEGA: 10
Homologene: 12724
Slc26a5
Name: solute carrier family 26, member 5
Synonyms: Pres, prestin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80979
HGNC: HGNC:9359
Homologene: 69472
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, trabeculin alpha, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ep400
Name: E1A binding protein p400
Synonyms: mDomino, p400, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230935
Homologene: 14558
Crym
Name: crystallin, mu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12971
HGNC: HGNC:2418
Homologene: 1424
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Intersectin-L, Ese1, Sh3p17, EHSH1, Eh domain, SH3 domain regulator of endocytosis 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Stk17b
Name: serine/threonine kinase 17b (apoptosis-inducing)
Synonyms: Drak2, 3110009A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98267
Homologene: 31231
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22323
Homologene: 7592
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, Nedd4b, 1300012C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: SHP-2, Syp, SH2 domain-containing protein tyrosine phosphatase-2, PTP2C, PTP1D, SH-PTP2, Shp2, 2700084A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230393
Homologene: 9842
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: 1200003I18Rik, DAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, 9930018I23Rik, MAP1C, Swl, dynein heavy chain, retrograde transport, Dnchc1, Dnec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Chchd3
Name: coiled-coil-helix-coiled-coil-helix domain containing 3
Synonyms: 0610041L09Rik, 1700039J09Rik, Micos19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66075
Homologene: 9851
Actr8
Name: ARP8 actin-related protein 8
Synonyms: ARP8, 5730542K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56249
VEGA: 14
Homologene: 11286
Dhx16
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 16
Synonyms: Ddx16, DBP2, 2410006N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: Brctx, Brctd1, Ankrd32, 2700017A04Rik, C730024G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105377
Homologene: 13000
Phf11d
Name: PHD finger protein 11D
Synonyms: D14Ertd668e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219132
Homologene: 87807
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12032
Homologene: 7244
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68750
Homologene: 2218
Cd274
Name: CD274 antigen
Synonyms: Pdcd1lg1, PD-L1, B7-H1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60533
Homologene: 8560
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242553
Homologene: 18244
Fcrl1
Name: Fc receptor-like 1
Synonyms: mIFGP1, A230020G22Rik, mBXMH1, moFcRH1, BXMAS1-like, Fcrh1, IFGP1, moFcRH1S, moFcRH1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229499
Homologene: 50472
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Pgap2
Name: post-GPI attachment to proteins 2
Synonyms: Frag1, clpex, 1810006G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233575
Homologene: 137653
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, Dnahc7l, LOC380889, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Dnahc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Lama3
Name: laminin, alpha 3
Synonyms: [a]3B, nicein, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Tubgcp6
Name: tubulin, gamma complex associated protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328580
Homologene: 32477
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: 4930503E15Rik, Gm1557, LOC380658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Slc8a3
Name: solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms: Ncx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110893
Homologene: 62645
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225898
VEGA: 19
Homologene: 27044
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71310
Homologene: 57079
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Glu5R, 6430542K11Rik, Gprc1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPT I, M-CPTI, Cpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Bmp2k
Name: BMP2 inducible kinase
Synonyms: 4933417M22Rik, BIKE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140780
Homologene: 34134
Acan
Name: aggrecan
Synonyms: Agc1, Cspg1, b2b183Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210962
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Prpf18
Name: pre-mRNA processing factor 18
Synonyms: 2810441A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67229
Homologene: 2726
Glipr1l2
Name: GLI pathogenesis-related 1 like 2
Synonyms: 4921508O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67537
Homologene: 17579
Olfr713
Name: olfactory receptor 713
Synonyms: GA_x6K02T2PBJ9-9415724-9416677, P3, MOR263-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259036
Homologene: 17470
Nt5c2
Name: 5'-nucleotidase, cytosolic II
Synonyms: cN-II, PNT5, NT5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76952
HGNC: HGNC:8022
Homologene: 8158
Clstn2
Name: calsyntenin 2
Synonyms: CSTN2, Cst-2, CS2, 2900042C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64085
Homologene: 49698
Sra1
Name: steroid receptor RNA activator 1
Synonyms: Srap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 24068
Homologene: 11906
Zfp263
Name: zinc finger protein 263
Synonyms: NT2, 1200014J04Rik, mFPM315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74120
Homologene: 4197
Gm8104
Name: predicted gene 8104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 101056159
Fam53b
Name: family with sequence similarity 53, member B
Synonyms: A930008G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77938
Homologene: 8776
Stk16
Name: serine/threonine kinase 16
Synonyms: Embryo-Derived Protein Kinase, EDPK, PKL12, Krct
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20872
Homologene: 2739
Igkv10-94
Name: immunoglobulin kappa variable 10-94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667550
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 28,780,060 bp
  • A to C, chromosome 1 at 53,776,558 bp
  • A to T, chromosome 1 at 66,679,590 bp
  • C to A, chromosome 1 at 75,213,130 bp
  • T to C, chromosome 2 at 4,643,709 bp
  • A to G, chromosome 3 at 37,034,757 bp
  • C to T, chromosome 3 at 86,349,154 bp
  • A to G, chromosome 3 at 87,385,774 bp
  • G to T, chromosome 3 at 87,994,207 bp
  • A to T, chromosome 4 at 32,670,593 bp
  • G to A, chromosome 4 at 88,407,365 bp
  • A to G, chromosome 4 at 98,756,567 bp
  • A to C, chromosome 4 at 123,452,292 bp
  • A to G, chromosome 4 at 151,976,997 bp
  • T to C, chromosome 5 at 21,847,196 bp
  • A to G, chromosome 5 at 97,087,015 bp
  • G to A, chromosome 5 at 110,668,170 bp
  • A to G, chromosome 5 at 121,144,622 bp
  • T to C, chromosome 6 at 32,968,305 bp
  • T to C, chromosome 6 at 41,613,404 bp
  • C to A, chromosome 6 at 68,704,671 bp
  • T to C, chromosome 7 at 19,264,772 bp
  • T to C, chromosome 7 at 79,100,661 bp
  • A to G, chromosome 7 at 88,074,820 bp
  • T to C, chromosome 7 at 102,013,769 bp
  • T to C, chromosome 7 at 102,231,391 bp
  • C to A, chromosome 7 at 107,036,848 bp
  • T to C, chromosome 7 at 120,195,495 bp
  • T to A, chromosome 7 at 132,779,262 bp
  • T to A, chromosome 8 at 83,236,543 bp
  • G to T, chromosome 8 at 88,664,120 bp
  • C to T, chromosome 9 at 97,461,421 bp
  • A to T, chromosome 9 at 107,578,069 bp
  • G to C, chromosome 10 at 77,268,565 bp
  • C to T, chromosome 10 at 103,187,453 bp
  • T to C, chromosome 10 at 112,107,056 bp
  • C to A, chromosome 11 at 99,985,697 bp
  • A to G, chromosome 12 at 81,314,258 bp
  • G to A, chromosome 12 at 110,629,680 bp
  • T to A, chromosome 13 at 37,930,768 bp
  • T to A, chromosome 13 at 77,049,987 bp
  • A to G, chromosome 14 at 26,718,000 bp
  • A to T, chromosome 14 at 29,982,715 bp
  • A to G, chromosome 14 at 43,109,093 bp
  • A to T, chromosome 14 at 59,353,344 bp
  • A to G, chromosome 15 at 89,116,103 bp
  • A to G, chromosome 15 at 89,424,023 bp
  • A to G, chromosome 16 at 3,749,855 bp
  • A to G, chromosome 16 at 13,654,447 bp
  • G to A, chromosome 16 at 90,752,095 bp
  • A to G, chromosome 16 at 91,893,844 bp
  • T to A, chromosome 17 at 35,883,310 bp
  • T to G, chromosome 18 at 12,539,766 bp
  • C to A, chromosome 18 at 34,651,689 bp
  • T to C, chromosome 18 at 36,667,594 bp
  • A to G, chromosome 18 at 65,191,447 bp
  • T to A, chromosome 19 at 8,937,696 bp
  • A to G, chromosome 19 at 29,380,565 bp
  • C to T, chromosome 19 at 46,889,921 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5122 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042710-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.