Strain Name:
C57BL/6J-MtgxR5583Btlr/Mmmh
Stock Number:
043137-MU
Citation ID:
RRID:MMRRC_043137-MU
Other Names:
R5583 (G1), C57BL/6J-MtgxR5583Btlr
Major Collection:

Gene Information

Cdk6
Name: cyclin-dependent kinase 6
Synonyms: Crk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12571
HGNC: HGNC:1777
Homologene: 963
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Gena 52, GENA 60, GENA 47, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Abce1
Name: ATP-binding cassette, sub-family E (OABP), member 1
Synonyms: RNS4l (Eye), Oabp, Rnaseli
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 24015
HGNC: HGNC:69
Homologene: 2205
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 5033417D07Rik, BTF2, D5Ertd679e, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Styx
Name: serine/threonine/tyrosine interaction protein
Synonyms: STNS (alternatively spliced intron of Styx), 0610039A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56291
VEGA: 14
Homologene: 41331
Gon4l
Name: gon-4-like (C.elegans)
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76022
Homologene: 13002
Ssc4d
Name: scavenger receptor cysteine rich family, 4 domains
Synonyms: C330016E03Rik, Srcrb4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109267
Homologene: 34137
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74569
Homologene: 10100
Fxr1
Name: fragile X mental retardation gene 1, autosomal homolog
Synonyms: 1110050J02Rik, Fxr1p, 9530073J07Rik, Fxr1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, C030004M05Rik, 2410024A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2610034F17Rik, 2810422B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69956
Homologene: 41211
Helq
Name: helicase, POLQ-like
Synonyms: D430018E21Rik, Hel308
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 191578
Homologene: 14667
Alb
Name: albumin
Synonyms: Alb-1, Alb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Sqstm1
Name: sequestosome 1
Synonyms: A170, OSF-6, STAP, Osi, p62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18412
Homologene: 31202
Hp1bp3
Name: heterochromatin protein 1, binding protein 3
Synonyms: Hp1bp74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15441
Homologene: 7774
Per1
Name: period circadian clock 1
Synonyms: m-rigui, mPer1, Hftm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18626
HGNC: HGNC:8845
Homologene: 1966
Suv39h2
Name: suppressor of variegation 3-9 2
Synonyms: 4930507K23Rik, Suv39h histone methyltransferase, D2Ertd544e, KMT1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64707
Homologene: 32548
Hibch
Name: 3-hydroxyisobutyryl-Coenzyme A hydrolase
Synonyms: HIBYL-COA-H, 2610509I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227095
HGNC: HGNC:4908
Homologene: 5607
Plekhm3
Name: pleckstrin homology domain containing, family M, member 3
Synonyms: A230102O09Rik, Plekhm1l, 9430067K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241075
Homologene: 18459
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213121
Homologene: 16977
Afm
Name: afamin
Synonyms: Alf, alpha albumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
A1bg
Name: alpha-1-B glycoprotein
Synonyms: C44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 117586
VEGA: 15
HGNC: HGNC:5
Homologene: 11167
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329482
Homologene: 79722
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244234
Homologene: 133218
Gbp6
Name: guanylate binding protein 6
Synonyms: Mpa2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100702
Homologene: 128731
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Kremen2
Name: kringle containing transmembrane protein 2
Synonyms: 2900054E04Rik, Krm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73016
VEGA: 17
Homologene: 65132
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243914
Homologene: 16408
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 433619
Homologene: 54921
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, GIRK2, KCNJ7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, 4732458A06Rik, D130016K21Rik, 9430063L05Rik, Usmg4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83679
Homologene: 66961
Scarf1
Name: scavenger receptor class F, member 1
Synonyms: SREC, SREC-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380713
Homologene: 2741
Gata5os
Name: GATA binding protein 5, opposite strand
Synonyms: Gm14318
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100036520
Steap1
Name: six transmembrane epithelial antigen of the prostate 1
Synonyms: Prss24, 2410007B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70358
Homologene: 8256
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Spdya
Name: speedy/RINGO cell cycle regulator family, member A
Synonyms: 4930548B21Rik, 4921517J08Rik, Spdy1, speedy/ringo, speedy A2, speedy A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70891
Homologene: 16357
Spata7
Name: spermatogenesis associated 7
Synonyms: HSD3, B230306G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104871
Homologene: 10189
Tmem79
Name: transmembrane protein 79
Synonyms: 2310074C17Rik, 2310042N02Rik, mattrin, Matt, ma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71913
Homologene: 11492
Tfb2m
Name: transcription factor B2, mitochondrial
Synonyms: Hkp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15278
Homologene: 7362
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 215384
Homologene: 68369
Trim5
Name: tripartite motif-containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667823
Homologene: 75345
Gpr180
Name: G protein-coupled receptor 180
Synonyms: ITR, E130016I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58245
VEGA: 14
Homologene: 32506
Fam217a
Name: family with sequence similarity 217, member A
Synonyms: 1700026J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71864
VEGA: 13
Homologene: 82344
Fam149b
Name: family with sequence similarity 149, member B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105428
VEGA: 14
Homologene: 67023
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Olfr93
Name: olfactory receptor 93
Synonyms: MOR256-39P, GA_x6K02T2PSCP-1592036-1591098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258051
HGNC: HGNC:8252
Homologene: 79436
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 639781
Homologene: 87538
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18725
HGNC: HGNC:6607
Homologene: 134028
Nkx2-6
Name: NK2 homeobox 6
Synonyms: Tix, Nkx2.6, tinman, Nkx-2.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18092
Homologene: 22604
Itpripl2
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 2
Synonyms: E030018N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319622
Homologene: 45882
Zfp2
Name: zinc finger protein 2
Synonyms: mkr-2, Zfp-2, Fnp-2, 9930007F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22678
Homologene: 121779
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: 4933405P08Rik, SPEER-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71026
Homologene: 69402
Cops9
Name: COP9 signalosome subunit 9
Synonyms: 1110002M09Rik, Myeov2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66915
Homologene: 82250
Tlcd1
Name: TLC domain containing 1
Synonyms: 0610030G03Rik, 0610007A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68385
Homologene: 12263
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 46,242,199 bp
  • T to A, chromosome 1 at 52,901,247 bp
  • C to T, chromosome 1 at 64,937,986 bp
  • A to G, chromosome 1 at 66,416,037 bp
  • A to T, chromosome 1 at 92,639,767 bp
  • A to G, chromosome 1 at 179,545,881 bp
  • T to A, chromosome 2 at 3,474,853 bp
  • C to T, chromosome 2 at 91,480,712 bp
  • A to T, chromosome 2 at 94,377,682 bp
  • T to C, chromosome 2 at 106,365,433 bp
  • A to T, chromosome 2 at 180,334,254 bp
  • C to A, chromosome 3 at 34,068,976 bp
  • T to C, chromosome 3 at 88,332,563 bp
  • T to A, chromosome 3 at 88,899,971 bp
  • T to A, chromosome 3 at 92,824,336 bp
  • G to T, chromosome 3 at 96,684,903 bp
  • C to T, chromosome 3 at 97,747,576 bp
  • T to C, chromosome 3 at 122,148,901 bp
  • T to C, chromosome 3 at 148,859,164 bp
  • T to A, chromosome 4 at 8,752,473 bp
  • A to C, chromosome 4 at 112,019,056 bp
  • A to G, chromosome 4 at 138,222,115 bp
  • T to A, chromosome 5 at 3,344,436 bp
  • A to G, chromosome 5 at 5,740,579 bp
  • G to A, chromosome 5 at 13,794,768 bp
  • A to T, chromosome 5 at 90,468,593 bp
  • T to C, chromosome 5 at 90,547,881 bp
  • T to C, chromosome 5 at 100,762,593 bp
  • A to T, chromosome 5 at 105,277,685 bp
  • C to T, chromosome 5 at 124,584,297 bp
  • A to T, chromosome 5 at 135,970,196 bp
  • A to G, chromosome 6 at 71,902,936 bp
  • A to G, chromosome 7 at 3,842,546 bp
  • T to C, chromosome 7 at 28,091,579 bp
  • A to G, chromosome 7 at 31,061,137 bp
  • T to A, chromosome 7 at 104,276,835 bp
  • G to T, chromosome 7 at 118,489,878 bp
  • G to A, chromosome 7 at 140,296,826 bp
  • G to T, chromosome 8 at 79,690,293 bp
  • T to C, chromosome 10 at 44,003,510 bp
  • T to C, chromosome 10 at 115,478,504 bp
  • T to C, chromosome 10 at 127,588,463 bp
  • C to T, chromosome 11 at 50,206,057 bp
  • T to C, chromosome 11 at 50,900,157 bp
  • A to T, chromosome 11 at 55,253,889 bp
  • A to G, chromosome 11 at 69,103,445 bp
  • T to C, chromosome 11 at 75,514,016 bp
  • T to G, chromosome 11 at 78,178,936 bp
  • A to T, chromosome 12 at 98,669,331 bp
  • T to C, chromosome 12 at 105,649,155 bp
  • C to A, chromosome 13 at 34,910,297 bp
  • A to G, chromosome 14 at 20,363,300 bp
  • T to A, chromosome 14 at 45,371,026 bp
  • T to C, chromosome 14 at 69,171,823 bp
  • C to T, chromosome 14 at 118,162,698 bp
  • A to T, chromosome 15 at 60,921,234 bp
  • T to C, chromosome 16 at 37,061,807 bp
  • T to C, chromosome 16 at 94,833,201 bp
  • T to C, chromosome 17 at 23,742,255 bp
  • T to C, chromosome 17 at 37,151,594 bp
  • C to A, chromosome 17 at 71,569,131 bp
  • A to T, chromosome 17 at 75,291,330 bp
  • T to A, chromosome 19 at 9,006,917 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5583 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043137-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.