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Strain Name:
C57BL/6J-MtgxR5799Btlr/Mmmh
Stock Number:
043388-MU
Citation ID:
RRID:MMRRC_043388-MU
Other Names:
R5799 (G1)
Major Collection:

Strain Information

Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: Hbp, 1200004O12Rik, 5730456G07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Atg14
Name: autophagy related 14
Synonyms: D14Ertd114e, D14Ertd436e, Barkor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504663
VEGA: 14
Homologene: 45423
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 6030449K19Rik, 2900036C23Rik, 2410152H17Rik, 2810413I22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: 5033402L14Rik, SNAT2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241624
Homologene: 17627
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 49,338,148 bp
  • A to C, chromosome 1 at 85,577,329 bp
  • C to T, chromosome 1 at 130,741,171 bp
  • A to G, chromosome 1 at 183,395,934 bp
  • A to T, chromosome 2 at 52,720,910 bp
  • G to T, chromosome 2 at 93,811,972 bp
  • T to C, chromosome 2 at 93,864,403 bp
  • A to G, chromosome 2 at 112,686,580 bp
  • A to G, chromosome 2 at 119,538,781 bp
  • G to A, chromosome 2 at 172,416,187 bp
  • G to T, chromosome 3 at 27,335,593 bp
  • A to T, chromosome 3 at 142,632,082 bp
  • A to G, chromosome 4 at 48,433,295 bp
  • C to T, chromosome 4 at 155,610,026 bp
  • C to T, chromosome 5 at 105,481,342 bp
  • T to C, chromosome 5 at 107,109,608 bp
  • A to G, chromosome 5 at 144,830,945 bp
  • A to T, chromosome 6 at 3,707,592 bp
  • A to G, chromosome 6 at 87,731,182 bp
  • T to A, chromosome 7 at 13,296,258 bp
  • G to A, chromosome 7 at 132,705,635 bp
  • T to A, chromosome 8 at 21,250,343 bp
  • T to A, chromosome 8 at 25,748,602 bp
  • C to T, chromosome 8 at 71,678,700 bp
  • G to A, chromosome 9 at 24,725,520 bp
  • T to C, chromosome 9 at 39,874,096 bp
  • G to A, chromosome 9 at 59,708,016 bp
  • A to G, chromosome 10 at 61,849,140 bp
  • A to G, chromosome 10 at 78,052,026 bp
  • A to C, chromosome 10 at 91,122,041 bp
  • T to A, chromosome 10 at 96,002,948 bp
  • T to C, chromosome 10 at 116,112,769 bp
  • A to T, chromosome 10 at 129,945,911 bp
  • T to C, chromosome 11 at 119,916,691 bp
  • T to C, chromosome 11 at 121,244,654 bp
  • T to C, chromosome 12 at 21,168,246 bp
  • T to C, chromosome 12 at 112,778,930 bp
  • A to T, chromosome 14 at 47,547,295 bp
  • A to T, chromosome 14 at 49,929,040 bp
  • A to G, chromosome 15 at 78,250,977 bp
  • A to T, chromosome 15 at 96,695,089 bp
  • G to A, chromosome 15 at 99,966,824 bp
  • T to A, chromosome 16 at 36,184,261 bp
  • T to C, chromosome 16 at 52,309,849 bp
  • G to A, chromosome 16 at 56,139,105 bp
  • A to G, chromosome 17 at 24,885,798 bp
  • T to C, chromosome 17 at 35,394,139 bp
  • T to C, chromosome 18 at 89,037,946 bp
  • A to T, chromosome 19 at 8,782,631 bp
  • T to C, chromosome 19 at 33,777,693 bp
  • G to A, chromosome 19 at 45,036,989 bp
  • A to T, chromosome 19 at 56,342,169 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5799 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043388-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.