Chemically-induced point mutation in the Apc gene (MGI:88039) causing a truncation in the Apc protein.
Hetero/Hemizygous: intestinal neoplasia, adenomas develop primarily in the small intestine with the preponderance of the adenomas developing in the distal have (illium) of small intestine.
Animals are maintained on breeder chow (5058 PicoLab Mouse Diet 20).
|Viability and Fertility:||Female||Male||Comments|
|Homozygotes are viable:||No||No|
|Homozygotes are fertile:||No||No|
|Heterozygotes are fertile:||Reduced||Yes|
|Age Reproductive Decline:||Less than 4 months||Less than 4 months|
Limited quantities of breeder mice (up to 2 males and 2 females or 4 mice) per investigator per month are available from a live colony, usually available to ship in under 12 weeks. Larger quantities may be available, please contact the distributing center directly at email@example.com for more details.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.
|MMRRC Item #||Description||Distribution Fee / Unit (US $)||Units||Notes|
|Heterozygous / Hemizygous Female
Heterozygous / Hemizygous Male
Wild Type Female
Wild Type Male
|$290.00 / $590.00
Non-Profit / For-Profit
|Per Mouse||The firstname.lastname@example.org may assess additional fees for any special requests (e.g., specific age or weight of mice, etc.).|
|043849-MU-EMBRYO||Cryo-preserved embryos||$1,038.00 / $2,621.00
Non-Profit / For-Profit
|Aliquot||Approximate quantity3 : 20-40 embryos / aliquot|
1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.
2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.
3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.