Strain Name:
C57BL/6J-MtgxR6388Btlr/Mmmh
Stock Number:
044537-MU
Citation ID:
RRID:MMRRC_044537-MU
Other Names:
R6388 (G1)
Major Collection:

Strain Information

Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: NO, 2310005C01Rik, nNOS, bNOS, Nos-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Golga1
Name: golgin A1
Synonyms: Golgi97, golgin-97, awag, 0710001G09Rik, 2210418B03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22788
Homologene: 5178
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Syvn1
Name: synovial apoptosis inhibitor 1, synoviolin
Synonyms: 1200010C09Rik, Hrd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74126
Homologene: 32700
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Fam3b
Name: FAM3 metabolism regulating signaling molecule B
Synonyms: 9030624C24Rik, Pander, ORF9, D16Jhu19e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52793
HGNC: HGNC:1253
Homologene: 10766
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: b2b1660Clo, Adtb1, beta-prime adaptin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Gpatch8
Name: G patch domain containing 8
Synonyms: Fbm1, ENSMUSG00000075516, 5430405G24Rik, Gpatc8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237943
Homologene: 46117
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: ST3GalI, Siat4, Siat4a, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Or1e35
Name: olfactory receptor family 1 subfamily E member 35
Synonyms: MOR135-10, GA_x6K02T2P1NL-4062605-4061667, Olfr395
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259007
Abi3
Name: ABI family member 3
Synonyms: 2210414K06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66610
Homologene: 9505
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: BAF60C, 2210409C08Rik, 1500001J14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66993
Homologene: 2314
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Fam98c
Name: family with sequence similarity 98, member C
Synonyms: 1110006G06Rik, B230110F21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73833
Homologene: 45483
Car5a
Name: carbonic anhydrase 5a, mitochondrial
Synonyms: Car5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12352
HGNC: HGNC:1377
Homologene: 68200
Iglon5
Name: IgLON family member 5
Synonyms: A230106M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210094
Homologene: 46295
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9S, IIIG9L, Ppp1r32, IIIG9, 4930579J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Vmn1r13
Name: vomeronasal 1 receptor 13
Synonyms: V1rc5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113862
Homologene: 74368
Icosl
Name: icos ligand
Synonyms: GL50-B, B7RP-1, B7h, B7-H2, ICOS-L, LICOS, GL50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Setdb2
Name: SET domain, bifurcated 2
Synonyms: KMT1F, LOC239122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239122
Homologene: 12903
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
Defb30
Name: defensin beta 30
Synonyms: 2410125J01Rik, 4930449O14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73670
Homologene: 86862
Atpaf2
Name: ATP synthase mitochondrial F1 complex assembly factor 2
Synonyms: ATP12p, ATP12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246782
Homologene: 34602
Ugp2
Name: UDP-glucose pyrophosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216558
Homologene: 121676
Ciao1
Name: cytosolic iron-sulfur protein assembly 1
Synonyms: Wdr39
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26371
Homologene: 55850
Pla1a
Name: phospholipase A1 member A
Synonyms: Ps-pla1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 85031
VEGA: 16
Homologene: 9294
Timm22
Name: translocase of inner mitochondrial membrane 22
Synonyms: 2610511O07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56322
Homologene: 32173
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 38,019,000 bp
  • T to C, chromosome 2 at 39,023,171 bp
  • C to A, chromosome 2 at 76,790,845 bp
  • A to T, chromosome 2 at 127,246,476 bp
  • T to C, chromosome 4 at 145,155,574 bp
  • A to G, chromosome 5 at 24,596,026 bp
  • A to G, chromosome 5 at 108,201,348 bp
  • A to G, chromosome 5 at 117,914,436 bp
  • A to G, chromosome 5 at 124,829,646 bp
  • T to C, chromosome 5 at 135,982,694 bp
  • T to A, chromosome 6 at 57,209,918 bp
  • C to T, chromosome 7 at 29,155,303 bp
  • T to C, chromosome 7 at 43,478,132 bp
  • C to T, chromosome 7 at 59,304,921 bp
  • T to C, chromosome 8 at 121,927,171 bp
  • T to A, chromosome 10 at 78,069,532 bp
  • T to C, chromosome 11 at 5,026,319 bp
  • T to C, chromosome 11 at 6,224,145 bp
  • A to G, chromosome 11 at 21,322,051 bp
  • C to A, chromosome 11 at 60,417,007 bp
  • A to G, chromosome 11 at 73,907,292 bp
  • G to A, chromosome 11 at 76,407,119 bp
  • A to G, chromosome 11 at 95,833,638 bp
  • A to T, chromosome 11 at 102,478,488 bp
  • A to G, chromosome 12 at 58,267,457 bp
  • C to T, chromosome 13 at 68,590,200 bp
  • C to T, chromosome 13 at 77,262,111 bp
  • T to C, chromosome 14 at 59,424,697 bp
  • T to A, chromosome 14 at 63,049,764 bp
  • A to T, chromosome 15 at 8,300,784 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to A, chromosome 16 at 38,397,472 bp
  • T to C, chromosome 16 at 97,478,391 bp
  • A to G, chromosome 17 at 12,683,900 bp
  • A to G, chromosome 19 at 5,690,251 bp
  • T to A, chromosome 19 at 6,052,351 bp
  • A to G, chromosome 19 at 10,482,301 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6388 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044537-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.