Strain Name:
C57BL/6J-MtgxR6614Btlr/Mmmh
Stock Number:
044737-MU
Citation ID:
RRID:MMRRC_044737-MU
Other Names:
R6614 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, N-CoR, 5730405M06Rik, Rxrip13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Neurog1
Name: neurogenin 1
Synonyms: Neurod3, neurogenin, bHLHa6, ngn1, neurogenin 1, Math4C
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18014
VEGA: 13
HGNC: HGNC:7764
Homologene: 4490
Ndufv1
Name: NADH:ubiquinone oxidoreductase core subunit V1
Synonyms: 24 kDa (FP)
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17995
HGNC: HGNC:7716
Homologene: 5151
2810004N23Rik
Name: RIKEN cDNA 2810004N23 gene
Synonyms: GtAyu21-55, Ayu21-55, Gt(Ayu21)55Imeg
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66523
Homologene: 11982
Srsf11
Name: serine and arginine-rich splicing factor 11
Synonyms: Sfrs11, 0610009J05Rik, 2610019N13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69207
Homologene: 36164
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Bysl
Name: bystin-like
Synonyms: Enp1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53414
VEGA: 17
HGNC: HGNC:1157
Homologene: 2991
Lima1
Name: LIM domain and actin binding 1
Synonyms: 3526402A12Rik, 1110021C24Rik, epithelial protein lost in neoplasm, EPLIN
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 65970
Homologene: 9484
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, Uhrf1bp1, F830021D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Rex2
Name: reduced expression 2
Synonyms: Gm13138
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100043034
Homologene: 133076
Elavl1
Name: ELAV like RNA binding protein 1
Synonyms: HuR, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R), Hua, W91709, 2410055N02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15568
HGNC: HGNC:3312
Homologene: 20367
Trmt1
Name: tRNA methyltransferase 1
Synonyms: 6720406L13Rik, D8Ertd812e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212528
Homologene: 5632
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Adamts4
Name: ADAM metallopeptidase with thrombospondin type 1 motif 4
Synonyms: aggrecanase-1, ADAM-TS4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240913
HGNC: HGNC:220
Homologene: 36169
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6, Efa6a, 1110007H17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Oog4
Name: oogenesin 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242737
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: OTTMUSG00000029174, C130026I21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Serac1
Name: serine active site containing 1
Synonyms: 4930511N22Rik, D17Ertd141e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321007
Homologene: 41900
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic PLA2, cytosolic phospholipase A2, cPLA2, Pla2g4, cPLA2alpha, Type IV PLA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: Kv11.3, erg3, 9330137I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170738
Homologene: 13249
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Oosp1
Name: oocyte secreted protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170834
Homologene: 87189
Or11a4
Name: olfactory receptor family 11 subfamily A member 4
Synonyms: MOR121-1, Olfr96, GA_x6K02T2PSCP-1665046-1665987
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258507
HGNC: HGNC:8176
Homologene: 27189
Stxbp6
Name: syntaxin binding protein 6 (amisyn)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217517
Homologene: 8579
Or11g24
Name: olfactory receptor family 11 subfamily G member 24
Synonyms: Olfr739, MOR106-2, GA_x6K02T2PMLR-6121675-6122604
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258663
Homologene: 121549
Or4n4b
Name: olfactory receptor family 4 subfamily N member 4B
Synonyms: GA_x6K02T2PMLR-5992342-5991416, Olfr733, MOR241-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258657
Homologene: 128266
Ptx4
Name: pentraxin 4
Synonyms: 1110018H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68509
VEGA: 17
Homologene: 19179
Pate7
Name: prostate and testis expressed 7
Synonyms: Gm17727
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312986
Homologene: 129804
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Or7a41
Name: olfactory receptor family 7 subfamily A member 41
Synonyms: Olfr57, IF12, GA_x6K02T2QGN0-2777431-2776472, MOR139-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18357
Homologene: 133620
P2rx3
Name: purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms: P2X3, 4930513E20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228139
HGNC: HGNC:8534
Homologene: 1922
Gnptg
Name: N-acetylglucosamine-1-phosphotransferase, gamma subunit
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214505
VEGA: 17
Homologene: 13047
Ifit3b
Name: interferon-induced protein with tetratricopeptide repeats 3B
Synonyms: I830012O16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667370
HGNC: HGNC:5411
Homologene: 1189
Or4k1
Name: olfactory receptor family 4 subfamily K member 1
Synonyms: GA_x6K02T2PMLR-5831021-5830086, MOR246-1P, Olfr728
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258039
Homologene: 74224
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 46,649,340 bp
  • A to G, chromosome 1 at 46,649,351 bp
  • A to C, chromosome 1 at 85,202,060 bp
  • A to T, chromosome 1 at 149,842,235 bp
  • A to G, chromosome 1 at 171,256,624 bp
  • T to G, chromosome 2 at 62,777,596 bp
  • C to T, chromosome 2 at 76,784,830 bp
  • A to G, chromosome 2 at 85,035,199 bp
  • C to T, chromosome 3 at 158,023,344 bp
  • A to G, chromosome 4 at 143,437,875 bp
  • A to T, chromosome 4 at 147,052,561 bp
  • C to A, chromosome 8 at 4,289,818 bp
  • C to T, chromosome 8 at 17,216,787 bp
  • T to A, chromosome 8 at 70,781,966 bp
  • G to T, chromosome 8 at 84,689,333 bp
  • T to A, chromosome 8 at 124,861,247 bp
  • A to G, chromosome 9 at 35,777,125 bp
  • C to T, chromosome 9 at 79,815,839 bp
  • C to A, chromosome 10 at 79,035,091 bp
  • T to A, chromosome 10 at 82,291,648 bp
  • A to T, chromosome 11 at 9,294,371 bp
  • T to C, chromosome 11 at 59,012,801 bp
  • A to C, chromosome 11 at 62,330,819 bp
  • T to A, chromosome 12 at 44,861,275 bp
  • T to G, chromosome 12 at 65,042,563 bp
  • A to T, chromosome 12 at 102,991,430 bp
  • T to C, chromosome 12 at 117,886,676 bp
  • G to T, chromosome 13 at 56,251,824 bp
  • A to T, chromosome 14 at 16,407,142 bp
  • T to A, chromosome 14 at 50,140,364 bp
  • T to A, chromosome 14 at 50,299,037 bp
  • C to T, chromosome 14 at 50,425,089 bp
  • A to G, chromosome 15 at 10,470,263 bp
  • G to A, chromosome 15 at 66,735,259 bp
  • G to A, chromosome 15 at 99,783,580 bp
  • A to T, chromosome 17 at 6,045,662 bp
  • A to T, chromosome 17 at 25,122,702 bp
  • T to C, chromosome 17 at 25,235,261 bp
  • T to A, chromosome 17 at 27,876,925 bp
  • T to C, chromosome 17 at 37,225,899 bp
  • A to T, chromosome 17 at 47,601,842 bp
  • T to G, chromosome 18 at 22,920,856 bp
  • G to A, chromosome 19 at 4,008,749 bp
  • T to A, chromosome 19 at 11,690,950 bp
  • A to T, chromosome 19 at 34,611,519 bp
  • A to G, chromosome 19 at 43,819,361 bp
  • T to C, chromosome 19 at 46,313,412 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6614 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044737-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.