Strain Name:
C57BL/6J-MtgxR6895Btlr/Mmmh
Stock Number:
044989-MU
Citation ID:
RRID:MMRRC_044989-MU
Other Names:
R6895 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Nup62
Name: nucleoporin 62
Synonyms: p62, Nupc1, D7Ertd649e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18226
HGNC: HGNC:8066
Homologene: 68773
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Larp4
Name: La ribonucleoprotein 4
Synonyms: D330037H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207214
VEGA: 15
Homologene: 19173
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Sfrp5
Name: secreted frizzled-related sequence protein 5
Synonyms: SARP3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54612
Homologene: 2268
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pib5pa, Pipp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Nmbr
Name: neuromedin B receptor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18101
HGNC: HGNC:7843
Homologene: 20560
Car14
Name: carbonic anhydrase 14
Synonyms: CA XIV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23831
HGNC: HGNC:1372
Homologene: 69105
Homer3
Name: homer scaffolding protein 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26558
Homologene: 37972
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100317
Homologene: 11764
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: Myst3, 9930021N24Rik, Zfp220, MOZ
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Ropn1
Name: ropporin, rhophilin associated protein 1
Synonyms: RHPNAP1, ODF6, 1700008N21Rik, ropporin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76378
Homologene: 57119
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Capn8
Name: calpain 8
Synonyms: nCL-2', nCL-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170725
HGNC: HGNC:1485
Homologene: 15643
Tas2r123
Name: taste receptor, type 2, member 123
Synonyms: Tas2r23, T2R23, mt2r55, mGR23, STC 9-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353167
Homologene: 45450
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, PI3Kgamma, p110gamma, 5830428L06Rik, PI(3)Kgamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: B230104L07Rik, GluRdelta2, tpr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: Ktu, 2810020C19Rik, 1110034A24Rik, kintoun
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109065
Homologene: 10026
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231396
Homologene: 128251
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235636
Homologene: 135957
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: 9130013M11Rik, Dra, 9030623B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Ankrd29
Name: ankyrin repeat domain 29
Synonyms: G630054C21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225187
Homologene: 17839
Or8b51
Name: olfactory receptor family 8 subfamily B member 51
Synonyms: MOR168-1, Olfr916, GA_x6K02T2PVTD-32360710-32359778
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258780
VEGA: 9
Homologene: 74147
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Or14a256
Name: olfactory receptor family 14 subfamily A member 256
Synonyms: GA_x6K02T2NHDJ-9504525-9505532, MOR219-5, Olfr294
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257904
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100504232
Homologene: 134535
C4bp
Name: complement component 4 binding protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12269
HGNC: HGNC:1325
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
Lrrc72
Name: leucine rich repeat containing 72
Synonyms: 1700108M19Rik, 4933421E18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71156
Homologene: 90358
Tex46
Name: testis expressed 46
Synonyms: 4930549C01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67663
Homologene: 136495
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 130,636,206 bp
  • G to A, chromosome 1 at 139,740,472 bp
  • A to C, chromosome 1 at 173,277,685 bp
  • C to A, chromosome 1 at 182,628,669 bp
  • A to G, chromosome 2 at 112,355,095 bp
  • G to A, chromosome 2 at 121,036,623 bp
  • T to A, chromosome 2 at 160,988,340 bp
  • C to T, chromosome 3 at 90,159,924 bp
  • T to C, chromosome 3 at 95,898,160 bp
  • C to T, chromosome 4 at 101,154,537 bp
  • T to C, chromosome 4 at 126,791,930 bp
  • T to C, chromosome 4 at 136,612,901 bp
  • G to A, chromosome 5 at 87,092,298 bp
  • T to C, chromosome 6 at 64,395,299 bp
  • A to T, chromosome 6 at 132,847,170 bp
  • A to G, chromosome 7 at 44,829,733 bp
  • A to T, chromosome 7 at 86,616,115 bp
  • G to T, chromosome 7 at 121,653,176 bp
  • T to G, chromosome 8 at 22,935,783 bp
  • T to C, chromosome 8 at 70,285,305 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • T to A, chromosome 8 at 94,243,686 bp
  • T to C, chromosome 8 at 110,312,251 bp
  • A to C, chromosome 9 at 38,658,089 bp
  • T to C, chromosome 9 at 110,987,196 bp
  • A to T, chromosome 10 at 14,769,960 bp
  • G to T, chromosome 10 at 22,692,185 bp
  • A to G, chromosome 10 at 67,217,090 bp
  • T to C, chromosome 11 at 3,495,557 bp
  • G to T, chromosome 12 at 31,463,524 bp
  • A to G, chromosome 12 at 32,204,347 bp
  • T to G, chromosome 12 at 36,209,718 bp
  • A to G, chromosome 12 at 69,197,663 bp
  • A to G, chromosome 12 at 71,063,302 bp
  • A to G, chromosome 12 at 117,995,191 bp
  • A to G, chromosome 13 at 48,892,021 bp
  • T to C, chromosome 14 at 16,413,604 bp
  • C to A, chromosome 14 at 111,681,653 bp
  • T to C, chromosome 15 at 47,666,514 bp
  • T to G, chromosome 15 at 100,007,730 bp
  • A to T, chromosome 16 at 34,677,298 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to G, chromosome 18 at 12,260,989 bp
  • A to T, chromosome 19 at 42,199,788 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6895 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.