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Strain Name:
C57BL/6J-MtgxR7266Btlr/Mmmh
Stock Number:
045389-MU
Citation ID:
RRID:MMRRC_045389-MU
Other Names:
R7266 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Ap2m1
Name: adaptor-related protein complex 2, mu 1 subunit
Synonyms: clathrin-associated AP-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11773
HGNC: HGNC:564
Homologene: 3000
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 8,682,019 bp
  • G to T, chromosome 1 at 82,882,245 bp
  • G to A, chromosome 1 at 120,022,225 bp
  • T to G, chromosome 2 at 12,232,901 bp
  • T to A, chromosome 2 at 39,000,264 bp
  • C to T, chromosome 2 at 76,732,574 bp
  • T to C, chromosome 2 at 146,334,568 bp
  • T to C, chromosome 2 at 164,820,482 bp
  • T to C, chromosome 2 at 165,807,572 bp
  • T to C, chromosome 2 at 181,135,092 bp
  • T to C, chromosome 3 at 135,517,912 bp
  • A to G, chromosome 4 at 72,139,687 bp
  • A to G, chromosome 4 at 108,718,547 bp
  • T to G, chromosome 4 at 141,642,459 bp
  • G to T, chromosome 5 at 137,114,243 bp
  • T to A, chromosome 6 at 28,417,996 bp
  • T to A, chromosome 6 at 71,874,705 bp
  • T to C, chromosome 6 at 134,507,401 bp
  • A to G, chromosome 7 at 80,307,657 bp
  • A to G, chromosome 7 at 81,092,580 bp
  • G to T, chromosome 7 at 85,738,274 bp
  • T to C, chromosome 7 at 112,303,756 bp
  • T to A, chromosome 7 at 123,001,367 bp
  • A to C, chromosome 8 at 10,272,687 bp
  • T to C, chromosome 8 at 11,425,542 bp
  • T to A, chromosome 8 at 24,667,623 bp
  • A to T, chromosome 8 at 25,827,205 bp
  • G to A, chromosome 8 at 33,623,203 bp
  • A to T, chromosome 8 at 70,164,288 bp
  • C to T, chromosome 8 at 85,007,764 bp
  • T to C, chromosome 9 at 37,623,013 bp
  • T to C, chromosome 9 at 40,961,157 bp
  • T to C, chromosome 9 at 49,114,541 bp
  • C to T, chromosome 9 at 106,647,171 bp
  • G to T, chromosome 9 at 119,562,560 bp
  • A to T, chromosome 10 at 74,379,390 bp
  • A to G, chromosome 10 at 78,612,614 bp
  • C to T, chromosome 10 at 114,800,871 bp
  • G to A, chromosome 11 at 53,859,251 bp
  • T to A, chromosome 11 at 55,285,030 bp
  • C to T, chromosome 11 at 96,773,159 bp
  • A to G, chromosome 11 at 109,453,281 bp
  • C to T, chromosome 13 at 97,965,452 bp
  • T to A, chromosome 14 at 8,146,220 bp
  • T to A, chromosome 14 at 56,685,040 bp
  • T to C, chromosome 14 at 60,974,698 bp
  • C to G, chromosome 15 at 25,782,981 bp
  • C to A, chromosome 15 at 34,959,036 bp
  • A to T, chromosome 15 at 58,627,597 bp
  • A to T, chromosome 15 at 78,433,014 bp
  • A to G, chromosome 15 at 94,931,803 bp
  • T to A, chromosome 15 at 95,435,393 bp
  • A to G, chromosome 16 at 20,543,345 bp
  • C to T, chromosome 16 at 56,770,311 bp
  • C to A, chromosome 17 at 29,519,373 bp
  • A to G, chromosome 17 at 33,601,694 bp
  • A to G, chromosome 18 at 37,839,975 bp
  • A to G, chromosome 18 at 60,629,559 bp
  • G to T, chromosome 19 at 55,304,500 bp
  • A to G, chromosome 19 at 61,175,535 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7266 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045389-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.