Strain Name:
C57BL/6J-MtgxR7461Btlr/Mmmh
Stock Number:
045535-MU
Citation ID:
RRID:MMRRC_045535-MU
Other Names:
R7461 (G1)
Major Collection:

Strain Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Gjd2
Name: gap junction protein, delta 2
Synonyms: Cx36, connexin36, Gja9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14617
Homologene: 7734
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Por
Name: cytochrome p450 oxidoreductase
Synonyms: 4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18984
HGNC: HGNC:9208
Homologene: 725
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59008
Homologene: 41118
Exoc2
Name: exocyst complex component 2
Synonyms: 2410030I24Rik, Sec5, Sec5l1, Gm29675
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
Foxn2
Name: forkhead box N2
Synonyms: 6030465J18Rik, HTLF, 3230402J05Rik, Fkh19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14236
HGNC: HGNC:5281
Homologene: 31078
Hdac2
Name: histone deacetylase 2
Synonyms: Yy1bp, D10Wsu179e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15182
HGNC: HGNC:4853
Homologene: 68187
Dpp8
Name: dipeptidylpeptidase 8
Synonyms: 4932434F09Rik, 2310004I03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74388
VEGA: 9
Homologene: 57098
Prkcq
Name: protein kinase C, theta
Synonyms: Pkcq, PKC-0, PKC theta, PKC-theta, A130035A12Rik, PKCtheta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71888
Homologene: 74433
Dcc
Name: deleted in colorectal carcinoma
Synonyms: Igdcc1, C030036D22Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Akt2
Name: thymoma viral proto-oncogene 2
Synonyms: 2410016A19Rik, PKBbeta, PKB
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11652
HGNC: HGNC:392
Homologene: 48773
Upf2
Name: UPF2 regulator of nonsense transcripts homolog (yeast)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 326622
Homologene: 6101
Crip2
Name: cysteine rich protein 2
Synonyms: Hlp, Crp, 0610010I23Rik, ESP1, CRP4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68337
HGNC: HGNC:2361
Homologene: 133917
Kansl3
Name: KAT8 regulatory NSL complex subunit 3
Synonyms: 4632411B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226976
Homologene: 9949
C1qtnf6
Name: C1q and tumor necrosis factor related protein 6
Synonyms: CTRP6, 2810036M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72709
Homologene: 12481
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216881
Homologene: 18590
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Invs
Name: inversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16348
Homologene: 7786
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Acta2
Name: actin alpha 2, smooth muscle, aorta
Synonyms: SMAalpha, SMalphaA, Actvs, 0610041G09Rik, alphaSMA, a-SMA
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, Adgrc2, flamingo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Tmem209
Name: transmembrane protein 209
Synonyms: 2700094F01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72649
Homologene: 18021
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: Gucy1b3, beta 1 sGC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a2, Cav1.3alpha1, 8430418G19Rik, Cchl1a, D-LTCC, Cacnl1a2, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: Ccdc147, LOC381229
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Megf10
Name: multiple EGF-like-domains 10
Synonyms: 3000002B06Rik, LOC240312
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: Slack, C030030G16Rik, slo2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227632
Homologene: 11055
Myocd
Name: myocardin
Synonyms: Srfcp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214384
Homologene: 17043
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Itgbl1
Name: integrin, beta-like 1
Synonyms: with EGF-like repeat domains, B930011D01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Cenpj
Name: centromere protein J
Synonyms: Sas4, 4932437H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219103
Homologene: 10204
Cdkl1
Name: cyclin dependent kinase like 1
Synonyms: 4933411O17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71609
Homologene: 2807
Or5b21
Name: olfactory receptor family 5 subfamily B member 21
Synonyms: MOR202-4, GA_x6K02T2RE5P-3191201-3192160, Olfr1444
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258697
Homologene: 64906
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Klhl30
Name: kelch-like 30
Synonyms: 4631423F02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70788
Homologene: 18891
Selenoi
Name: selenoprotein I
Synonyms: C79563, 4933402G07Rik, Ept1, D5Wsu178e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 28042
Homologene: 100935
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Gm3676
Name: predicted gene 3676
Type: Gene
Species: Mouse
Chromosome: 14
Gm4131
Name: predicted gene 4131
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042960
Homologene: 132023
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 36,343,795 bp
  • G to T, chromosome 1 at 91,357,408 bp
  • G to T, chromosome 1 at 93,194,589 bp
  • T to A, chromosome 2 at 5,973,536 bp
  • T to C, chromosome 2 at 11,299,410 bp
  • A to T, chromosome 2 at 25,901,346 bp
  • A to G, chromosome 2 at 113,364,071 bp
  • A to C, chromosome 2 at 114,011,118 bp
  • A to T, chromosome 2 at 160,712,842 bp
  • T to A, chromosome 3 at 82,039,747 bp
  • C to T, chromosome 3 at 108,395,640 bp
  • T to C, chromosome 3 at 158,187,020 bp
  • A to G, chromosome 4 at 48,392,668 bp
  • A to G, chromosome 4 at 102,255,306 bp
  • T to C, chromosome 4 at 109,329,725 bp
  • A to T, chromosome 4 at 113,177,046 bp
  • CTATA to CTATATA, chromosome 4 at 130,021,213 bp
  • A to G, chromosome 5 at 30,266,928 bp
  • T to C, chromosome 5 at 105,031,014 bp
  • C to A, chromosome 5 at 111,224,129 bp
  • G to A, chromosome 5 at 122,818,865 bp
  • G to T, chromosome 5 at 135,729,504 bp
  • C to T, chromosome 6 at 30,508,470 bp
  • A to G, chromosome 7 at 27,637,170 bp
  • T to C, chromosome 8 at 77,388,697 bp
  • T to C, chromosome 8 at 105,260,564 bp
  • A to T, chromosome 9 at 27,334,122 bp
  • C to T, chromosome 9 at 65,053,120 bp
  • T to C, chromosome 10 at 36,989,236 bp
  • A to G, chromosome 11 at 60,505,152 bp
  • A to G, chromosome 11 at 65,218,603 bp
  • A to G, chromosome 11 at 69,548,990 bp
  • T to C, chromosome 11 at 71,759,973 bp
  • A to G, chromosome 11 at 100,011,939 bp
  • G to T, chromosome 11 at 103,616,290 bp
  • G to T, chromosome 11 at 115,786,256 bp
  • T to A, chromosome 12 at 69,756,461 bp
  • T to C, chromosome 12 at 113,144,157 bp
  • C to T, chromosome 13 at 30,882,272 bp
  • A to T, chromosome 14 at 30,066,163 bp
  • T to A, chromosome 14 at 41,643,276 bp
  • G to A, chromosome 14 at 56,527,044 bp
  • A to G, chromosome 14 at 62,481,089 bp
  • T to A, chromosome 14 at 123,827,799 bp
  • T to A, chromosome 15 at 78,527,349 bp
  • T to A, chromosome 17 at 30,988,057 bp
  • T to C, chromosome 17 at 43,627,926 bp
  • T to C, chromosome 17 at 88,486,883 bp
  • G to T, chromosome 18 at 57,252,853 bp
  • A to T, chromosome 18 at 71,306,034 bp
  • A to C, chromosome 18 at 78,856,492 bp
  • A to T, chromosome 19 at 12,861,777 bp
  • G to A, chromosome 19 at 34,252,531 bp
  • A to G, chromosome 19 at 47,982,122 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7461 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045535-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.