Strain Name:
C57BL/6J-MtgxR7557Btlr/Mmmh
Stock Number:
045652-MU
Citation ID:
RRID:MMRRC_045652-MU
Other Names:
R7557 (G1)
Major Collection:

Strain Information

Emb
Name: embigin
Synonyms: Gp70
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13723
Homologene: 7743
Mok
Name: MOK protein kinase
Synonyms: MAPK/MAK/MRK/ overlapping kinase, Stk30, MOK, Rage
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26448
HGNC: HGNC:9833
Homologene: 8062
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: Ggta, GALT, glycoprotein alpha galactosyl transferase 1, Ggta-1, Gal, alpha Gal, alpha3GalT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Npps2, Pdnp2, PD-Ialpha, Autotaxin, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Fbxo28
Name: F-box protein 28
Synonyms: Fbx28, 4833428J17Rik, D1Ertd578e, 5730505P19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67948
Homologene: 9050
Tut7
Name: terminal uridylyl transferase 7
Synonyms: 6030448M23Rik, Zcchc6, Tent3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: 2810431N21Rik, PEPP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Rasa2
Name: RAS p21 protein activator 2
Synonyms: 5430433H21Rik, GAP1m
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Gps1
Name: G protein pathway suppressor 1
Synonyms: Csn1, COPS1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209318
HGNC: HGNC:4549
Homologene: 3046
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Tcea1
Name: transcription elongation factor A (SII) 1
Synonyms: S-II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21399
Homologene: 55984
Sec22b
Name: SEC22 homolog B, vesicle trafficking protein
Synonyms: Sec22l1, ERS-24, 4930564D15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20333
Homologene: 3597
Add3
Name: adducin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 27360
VEGA: 19
HGNC: HGNC:245
Homologene: 40893
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Gask1b
Name: golgi associated kinase 1B
Synonyms: Ened, 2210419I08Rik, Fam198b, 1110032E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
Dctn2
Name: dynactin 2
Synonyms: C130077D06Rik, DCTN-50, p50, 2310042E05Rik, RBP50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Smad5
Name: SMAD family member 5
Synonyms: MusMLP, Madh5, Smad 5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17129
HGNC: HGNC:6771
Homologene: 4313
Cd209a
Name: CD209a antigen
Synonyms: CIRE, DC-SIGN1, SIGNR5, CD209, Dcsign, DC-SIGN
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170786
Homologene: 129771
Acaa2
Name: acetyl-CoA acyltransferase 2
Synonyms: 0610011L04Rik, D18Ertd240e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52538
VEGA: 18
HGNC: HGNC:83
Homologene: 4456
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230119
Homologene: 8913
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102634333
Homologene: 131709
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Msto1
Name: misato 1, mitochondrial distribution and morphology regulator
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229524
Homologene: 41228
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223752
Homologene: 18199
Plce1
Name: phospholipase C, epsilon 1
Synonyms: PLCepsilon, 4933403A21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Or10w1
Name: olfactory receptor family 10 subfamily W member 1
Synonyms: Olfr1490, GA_x6K02T2RE5P-3987000-3987950, MOR266-6P
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258098
Homologene: 79418
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320864
Homologene: 37118
Omg
Name: oligodendrocyte myelin glycoprotein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18377
HGNC: HGNC:8135
Homologene: 36099
Dipk2a
Name: divergent protein kinase domain 2A
Synonyms: 1190002N15Rik, GoPro49
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68861
Homologene: 18315
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Txndc15
Name: thioredoxin domain containing 15
Synonyms: 2310047H23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69672
VEGA: 13
Homologene: 32594
Slc18a1
Name: solute carrier family 18 (vesicular monoamine), member 1
Synonyms: 4832416I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110877
Homologene: 20664
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72614
Homologene: 12474
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: COX1, Cox-1, cyclooxygenase 1, Cox-3, Pghs1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Chp1
Name: calcineurin-like EF hand protein 1
Synonyms: 1500003O03Rik, vac, Sid470p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56398
Homologene: 5235
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: D8Ertd91e, 2310066G09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52065
Homologene: 3114
Pih1d1
Name: PIH1 domain containing 1
Synonyms: 1110061L23Rik, 4933413A04Rik, Nop17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68845
Homologene: 9914
Cacnb4
Name: calcium channel, voltage-dependent, beta 4 subunit
Synonyms: Cchb4, 3110038O15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12298
HGNC: HGNC:1404
Homologene: 20188
Klrc3
Name: killer cell lectin-like receptor subfamily C, member 3
Synonyms: NKG2E
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58179
Homologene: 130643
Gdi1
Name: GDP dissociation inhibitor 1
Synonyms: GDIA, Rab GDIalpha
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 14567
HGNC: HGNC:4226
Homologene: 37487
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 4,894,990 bp
  • G to T, chromosome 1 at 182,341,435 bp
  • T to C, chromosome 2 at 35,402,536 bp
  • T to C, chromosome 2 at 36,245,211 bp
  • T to C, chromosome 2 at 52,469,567 bp
  • T to A, chromosome 2 at 119,560,757 bp
  • T to A, chromosome 3 at 64,090,054 bp
  • A to G, chromosome 3 at 64,724,973 bp
  • A to T, chromosome 3 at 79,886,608 bp
  • A to G, chromosome 3 at 88,910,128 bp
  • A to G, chromosome 3 at 97,901,358 bp
  • C to T, chromosome 3 at 138,068,283 bp
  • T to C, chromosome 4 at 44,995,196 bp
  • A to G, chromosome 4 at 58,849,691 bp
  • T to G, chromosome 5 at 110,312,994 bp
  • T to C, chromosome 6 at 129,639,144 bp
  • T to C, chromosome 6 at 140,426,545 bp
  • A to G, chromosome 7 at 45,156,759 bp
  • T to A, chromosome 7 at 120,795,618 bp
  • T to A, chromosome 8 at 3,745,541 bp
  • T to A, chromosome 8 at 35,589,604 bp
  • T to C, chromosome 8 at 60,937,368 bp
  • T to A, chromosome 8 at 69,065,561 bp
  • A to T, chromosome 9 at 50,624,916 bp
  • T to C, chromosome 9 at 94,520,538 bp
  • T to C, chromosome 9 at 96,557,425 bp
  • C to A, chromosome 10 at 127,278,404 bp
  • T to A, chromosome 11 at 79,502,853 bp
  • G to T, chromosome 11 at 99,334,741 bp
  • T to C, chromosome 11 at 120,009,430 bp
  • C to T, chromosome 11 at 120,786,367 bp
  • A to G, chromosome 12 at 16,580,792 bp
  • A to T, chromosome 12 at 75,007,625 bp
  • A to G, chromosome 12 at 110,808,399 bp
  • T to A, chromosome 13 at 55,717,954 bp
  • T to C, chromosome 13 at 56,727,469 bp
  • T to C, chromosome 13 at 59,788,466 bp
  • T to A, chromosome 13 at 117,249,716 bp
  • A to T, chromosome 15 at 54,910,140 bp
  • C to T, chromosome 15 at 86,100,900 bp
  • C to T, chromosome 16 at 14,132,696 bp
  • CACTTAC to CAC, chromosome 16 at 90,772,573 bp
  • T to A, chromosome 18 at 37,722,794 bp
  • C to T, chromosome 18 at 74,795,159 bp
  • T to A, chromosome 19 at 13,655,026 bp
  • A to G, chromosome 19 at 38,765,404 bp
  • A to G, chromosome 19 at 53,239,437 bp
  • G to A, chromosome X at 74,306,855 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7557 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045652-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.