Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7864Btlr/Mmmh
Stock Number:
045917-MU
Citation ID:
RRID:MMRRC_045917-MU
Other Names:
R7864 (G1)
Major Collection:

Strain Information

Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19739
Homologene: 2845
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Ese1, EHSH1, Sh3p17, Eh domain, SH3 domain regulator of endocytosis 1, Intersectin-L
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, Tiul1, AIP5, 8030445B08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Rab1a
Name: RAB1A, member RAS oncogene family
Synonyms: ras-related YPT1 protein, Ypt1, Rab-1, Gtbp, Rab1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19324
HGNC: HGNC:9758
Homologene: 36154
Fancc
Name: Fanconi anemia, complementation group C
Synonyms: Facc
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14088
HGNC: HGNC:3584
Homologene: 109
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 66,484,560 bp
  • A to G, chromosome 3 at 28,926,470 bp
  • T to A, chromosome 3 at 32,443,613 bp
  • C to T, chromosome 3 at 64,691,526 bp
  • A to T, chromosome 3 at 95,734,376 bp
  • A to G, chromosome 3 at 129,918,623 bp
  • T to A, chromosome 4 at 19,635,328 bp
  • T to C, chromosome 4 at 141,628,046 bp
  • A to T, chromosome 5 at 8,410,010 bp
  • G to A, chromosome 5 at 127,783,916 bp
  • A to T, chromosome 6 at 30,631,395 bp
  • G to T, chromosome 6 at 38,628,089 bp
  • A to G, chromosome 6 at 124,625,287 bp
  • T to G, chromosome 7 at 18,610,510 bp
  • A to G, chromosome 8 at 23,087,960 bp
  • T to A, chromosome 8 at 24,922,276 bp
  • G to A, chromosome 8 at 93,274,141 bp
  • T to C, chromosome 8 at 95,559,669 bp
  • A to G, chromosome 8 at 105,688,274 bp
  • A to G, chromosome 9 at 9,984,177 bp
  • A to T, chromosome 9 at 36,534,451 bp
  • A to T, chromosome 10 at 7,839,959 bp
  • G to A, chromosome 10 at 27,056,615 bp
  • G to A, chromosome 10 at 45,315,182 bp
  • C to A, chromosome 10 at 54,030,747 bp
  • G to A, chromosome 10 at 97,725,752 bp
  • A to G, chromosome 10 at 107,869,567 bp
  • G to T, chromosome 11 at 20,215,673 bp
  • A to T, chromosome 11 at 109,275,620 bp
  • A to T, chromosome 12 at 57,542,747 bp
  • C to T, chromosome 12 at 83,988,022 bp
  • A to G, chromosome 12 at 87,122,882 bp
  • C to A, chromosome 12 at 112,765,123 bp
  • A to C, chromosome 13 at 42,158,814 bp
  • G to A, chromosome 13 at 55,093,267 bp
  • A to T, chromosome 13 at 58,578,403 bp
  • A to T, chromosome 13 at 63,400,259 bp
  • A to T, chromosome 13 at 67,621,450 bp
  • G to A, chromosome 14 at 24,245,212 bp
  • G to A, chromosome 14 at 40,840,251 bp
  • T to C, chromosome 15 at 44,526,053 bp
  • T to C, chromosome 15 at 78,888,244 bp
  • G to T, chromosome 16 at 50,262,434 bp
  • A to C, chromosome 16 at 64,926,794 bp
  • T to C, chromosome 16 at 91,801,566 bp
  • T to C, chromosome 17 at 5,342,255 bp
  • A to T, chromosome 17 at 26,970,528 bp
  • C to T, chromosome 17 at 56,047,339 bp
  • G to A, chromosome 17 at 71,700,940 bp
  • A to G, chromosome 19 at 12,771,039 bp
  • A to G, chromosome 19 at 13,749,346 bp
  • A to T, chromosome 19 at 25,163,500 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7864 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045917-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.