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Strain Name:
C57BL/6J-MtgxR7920Btlr/Mmmh
Stock Number:
045967-MU
Citation ID:
RRID:MMRRC_045967-MU
Other Names:
R7920 (G1)
Major Collection:

Strain Information

Htr3b
Name: 5-hydroxytryptamine (serotonin) receptor 3B
Synonyms: 5-HT3 receptor subunit B, 5-HT3B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57014
VEGA: 9
HGNC: HGNC:5298
Homologene: 38131
Pygb
Name: brain glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110078
HGNC: HGNC:9723
Homologene: 100930
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Cradd
Name: CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms: RAIDD
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12905
VEGA: 10
HGNC: HGNC:2340
Homologene: 2821
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Fkbp5
Name: FK506 binding protein 5
Synonyms: FKBP51, Dit1, D17Ertd592e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,275,535 bp
  • T to A, chromosome 1 at 37,367,805 bp
  • T to G, chromosome 1 at 87,705,949 bp
  • G to A, chromosome 1 at 139,062,873 bp
  • T to A, chromosome 1 at 166,099,896 bp
  • A to T, chromosome 2 at 24,971,612 bp
  • T to C, chromosome 2 at 25,626,286 bp
  • G to A, chromosome 2 at 25,779,331 bp
  • A to T, chromosome 2 at 76,795,157 bp
  • A to G, chromosome 2 at 82,951,021 bp
  • T to A, chromosome 2 at 134,548,252 bp
  • T to A, chromosome 2 at 150,787,002 bp
  • A to G, chromosome 2 at 168,262,984 bp
  • T to C, chromosome 3 at 5,400,455 bp
  • C to T, chromosome 3 at 129,735,840 bp
  • A to T, chromosome 4 at 12,089,284 bp
  • C to T, chromosome 4 at 45,489,054 bp
  • T to C, chromosome 4 at 106,707,576 bp
  • C to A, chromosome 4 at 107,071,008 bp
  • A to G, chromosome 4 at 130,819,196 bp
  • T to C, chromosome 4 at 141,632,121 bp
  • C to T, chromosome 4 at 147,862,918 bp
  • T to C, chromosome 5 at 34,167,702 bp
  • T to C, chromosome 5 at 43,739,309 bp
  • T to A, chromosome 5 at 52,405,094 bp
  • T to A, chromosome 5 at 73,101,807 bp
  • T to A, chromosome 5 at 100,663,875 bp
  • A to T, chromosome 6 at 8,742,274 bp
  • C to T, chromosome 7 at 4,483,355 bp
  • T to A, chromosome 7 at 11,009,772 bp
  • A to G, chromosome 7 at 16,793,870 bp
  • G to A, chromosome 7 at 25,271,959 bp
  • A to T, chromosome 7 at 30,105,592 bp
  • A to G, chromosome 7 at 55,816,562 bp
  • A to G, chromosome 7 at 127,587,953 bp
  • A to T, chromosome 7 at 140,667,901 bp
  • A to G, chromosome 9 at 18,302,101 bp
  • A to G, chromosome 9 at 45,146,771 bp
  • C to A, chromosome 9 at 48,937,156 bp
  • A to G, chromosome 9 at 109,058,089 bp
  • A to T, chromosome 9 at 122,895,909 bp
  • C to T, chromosome 10 at 42,197,769 bp
  • T to A, chromosome 10 at 51,614,930 bp
  • C to A, chromosome 10 at 80,834,548 bp
  • A to G, chromosome 10 at 95,322,711 bp
  • A to T, chromosome 11 at 115,254,144 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • G to A, chromosome 13 at 112,998,987 bp
  • T to C, chromosome 14 at 22,596,478 bp
  • A to G, chromosome 14 at 26,856,542 bp
  • T to C, chromosome 14 at 41,996,173 bp
  • A to G, chromosome 14 at 45,657,470 bp
  • A to T, chromosome 15 at 28,453,222 bp
  • T to A, chromosome 15 at 76,519,217 bp
  • C to T, chromosome 15 at 76,614,085 bp
  • C to T, chromosome 15 at 76,634,587 bp
  • A to G, chromosome 16 at 20,637,692 bp
  • A to T, chromosome 17 at 28,429,239 bp
  • A to G, chromosome 17 at 34,860,891 bp
  • A to C, chromosome 17 at 35,114,602 bp
  • A to G, chromosome 17 at 43,649,673 bp
  • A to T, chromosome 17 at 47,468,406 bp
  • A to G, chromosome 17 at 74,427,119 bp
  • A to T, chromosome 17 at 78,303,064 bp
  • C to G, chromosome 19 at 4,749,012 bp
  • T to A, chromosome 19 at 20,617,937 bp
  • T to C, chromosome 19 at 25,506,019 bp
  • T to G, chromosome 19 at 39,877,803 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7920 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045967-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.