Strain Name:
C57BL/6J-MtgxR8487Btlr/Mmmh
Stock Number:
067930-MU
Citation ID:
RRID:MMRRC_067930-MU
Other Names:
R8487 (G1)
Major Collection:

Strain Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: E430025J12Rik, Nedd4a, Nedd4, Nedd4-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: SKI-1, site-1 protease, subtilisin/kexin isozyme-1, S1P, 0610038M03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56453
Homologene: 2808
Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: PARP-7, PARP7, DDF1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99929
Homologene: 9167
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Mok
Name: MOK protein kinase
Synonyms: Rage, Stk30, MOK, MAPK/MAK/MRK/ overlapping kinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26448
HGNC: HGNC:9833
Homologene: 8062
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lphn2, Lec1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99633
Homologene: 22712
Zfp407
Name: zinc finger protein 407
Synonyms: 6430585N13Rik, LOC381139, LOC240469
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240476
Homologene: 86402
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: SNAT2, 5033402L14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67760
VEGA: 15
Homologene: 23132
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: 19G, Mcmd4, Cdc21, mCdc21
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Eloa
Name: elongin A
Synonyms: Tceb3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27224
Homologene: 37746
Ccdc47
Name: coiled-coil domain containing 47
Synonyms: asp4, 2610204L23Rik, calumin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67163
Homologene: 41351
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: D030073L15Rik, 2310076G09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Pax1
Name: paired box 1
Synonyms: wt, hunchback, wavy tail, Pax-1, hbs
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Hspa1a
Name: heat shock protein 1A
Synonyms: Hsp68, Hsp70a1, Hsp70-3, Hsp70.3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193740
Homologene: 74294
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Smarcd1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms: Baf60a, D15Kz1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83797
VEGA: 15
Homologene: 20670
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Fbn2
Name: fibrillin 2
Synonyms: sy, Fib-2, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 4930565N16Rik, 0710001E20Rik, tomosyn 1, LGL3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78808
Homologene: 16402
Zfp654
Name: zinc finger protein 654
Synonyms: 1810008K20Rik, 1600021C16Rik, Gm5488
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72020
Homologene: 10114
Gbe1
Name: 1,4-alpha-glucan branching enzyme 1
Synonyms: 2310045H19Rik, 2810426P10Rik, D16Ertd536e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Kif6
Name: kinesin family member 6
Synonyms: D130084M03Rik, D130004B10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319991
Homologene: 35308
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: prh, b2b1304Clo, D3Ertd789e, b2b1735Clo, b2b2025.1Clo, 4921507O14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: LOC380658, Gm1557, 4930503E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Rev, Sez4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72000
Homologene: 104159
Or5p73
Name: olfactory receptor family 5 subfamily P member 73
Synonyms: MOR204-36, GA_x6K02T2PBJ9-10795522-10796514, Olfr498
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258304
Homologene: 133600
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: 1810049O03Rik, C87354
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbccr1, Fam5a, Dbc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Catsperd
Name: cation channel sperm associated auxiliary subunit delta
Synonyms: Gm6095, 4933402B14Rik, Tmem146, 4921529N20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106757
VEGA: 17
Homologene: 51896
Vmn1r77
Name: vomeronasal 1 receptor 77
Synonyms: Gm6935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628946
Homologene: 103843
Zfp446
Name: zinc finger protein 446
Synonyms: A630035I11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269870
Homologene: 9910
Rbfox1
Name: RNA binding protein, fox-1 homolog (C. elegans) 1
Synonyms: A2bp, HRNBP1, FOX1, A2bp1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268859
VEGA: 16
Homologene: 69339
Or6c66
Name: olfactory receptor family 6 subfamily C member 66
Synonyms: MOR108-1, GA_x6K02T2PULF-11304679-11303744, Olfr798
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258549
Homologene: 133881
Or10g3b
Name: olfactory receptor family 10 subfamily G member 3B
Synonyms: Olfr1513, GA_x6K02T2RJGY-644134-645075, MOR223-10, MOR223-7P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258008
HGNC: HGNC:8171
Homologene: 79404
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: Olfr1256, GA_x6K02T2Q125-51276848-51275928, MOR231-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Or14c44
Name: olfactory receptor family 14 subfamily C member 44
Synonyms: MOR221-1P, MOR221-4, MOR211-8P, GA_x6K02T2NHDJ-9695951-9695766, MOR221-1P, Olfr301, Olfr302, Olfr1531-ps1, GA_x6K02T2NHDJ-9693313-9692378
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257958
Homologene: 128067
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: A330103J02Rik, Dlgh2, B330007M19Rik, PSD93, LOC382816, Chapsyn-110, B230218P12Rik, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15951
Homologene: 115929
Sgms1
Name: sphingomyelin synthase 1
Synonyms: SMS1alpha1, 9530058O11Rik, SMS1alpha2, SMS1beta, SMS1gamma, SMS1, Tmem23
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208449
Homologene: 27040
Pramel6
Name: PRAME like 6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 347711
Homologene: 77635
Polr3h
Name: polymerase (RNA) III (DNA directed) polypeptide H
Synonyms: 5031409G22Rik, RPC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78929
VEGA: 15
Homologene: 6337
Pcdhga12
Name: protocadherin gamma subfamily A, 12
Synonyms: pc2c, Pcdh13
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93724
HGNC: HGNC:8699
Homologene: 134588
Spcs1
Name: signal peptidase complex subunit 1 homolog (S. cerevisiae)
Synonyms: 1810004F21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69019
Homologene: 40915
Trav14d-3-dv8
Name: T cell receptor alpha variable 14D-3-DV8
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 634322
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 39,988,976 bp
  • G to A, chromosome 1 at 173,760,273 bp
  • A to C, chromosome 2 at 20,881,305 bp
  • C to T, chromosome 2 at 87,508,701 bp
  • T to C, chromosome 2 at 89,835,265 bp
  • G to T, chromosome 2 at 125,775,582 bp
  • A to T, chromosome 2 at 146,388,543 bp
  • A to G, chromosome 2 at 147,365,048 bp
  • T to A, chromosome 3 at 33,832,659 bp
  • T to A, chromosome 3 at 65,546,234 bp
  • T to C, chromosome 3 at 87,989,209 bp
  • A to G, chromosome 3 at 93,469,562 bp
  • T to C, chromosome 3 at 148,859,486 bp
  • C to T, chromosome 4 at 68,829,455 bp
  • G to A, chromosome 4 at 136,009,357 bp
  • A to G, chromosome 4 at 145,155,247 bp
  • T to A, chromosome 5 at 21,899,029 bp
  • A to T, chromosome 6 at 57,405,181 bp
  • C to G, chromosome 6 at 91,250,864 bp
  • C to T, chromosome 6 at 113,568,226 bp
  • T to A, chromosome 7 at 12,041,587 bp
  • T to A, chromosome 7 at 12,982,628 bp
  • T to C, chromosome 7 at 23,321,558 bp
  • T to C, chromosome 7 at 29,040,867 bp
  • A to G, chromosome 7 at 86,412,439 bp
  • A to T, chromosome 7 at 92,286,588 bp
  • G to T, chromosome 7 at 108,465,577 bp
  • G to A, chromosome 7 at 141,210,514 bp
  • C to A, chromosome 8 at 4,234,218 bp
  • A to T, chromosome 8 at 61,974,150 bp
  • C to T, chromosome 8 at 119,541,674 bp
  • T to C, chromosome 9 at 72,670,039 bp
  • A to G, chromosome 9 at 122,749,936 bp
  • T to C, chromosome 10 at 9,812,289 bp
  • T to A, chromosome 10 at 39,806,848 bp
  • T to A, chromosome 10 at 88,432,646 bp
  • T to C, chromosome 10 at 103,215,053 bp
  • A to G, chromosome 10 at 129,625,245 bp
  • A to C, chromosome 11 at 60,783,996 bp
  • A to T, chromosome 11 at 103,928,758 bp
  • C to A, chromosome 11 at 106,202,145 bp
  • A to G, chromosome 12 at 110,809,907 bp
  • T to A, chromosome 14 at 31,000,764 bp
  • A to T, chromosome 14 at 52,349,239 bp
  • A to T, chromosome 14 at 53,078,735 bp
  • T to C, chromosome 15 at 81,916,623 bp
  • G to A, chromosome 15 at 96,695,291 bp
  • T to A, chromosome 15 at 99,707,776 bp
  • G to A, chromosome 16 at 7,224,455 bp
  • C to A, chromosome 16 at 15,632,178 bp
  • A to T, chromosome 16 at 64,785,648 bp
  • A to G, chromosome 16 at 70,436,988 bp
  • T to A, chromosome 17 at 34,972,057 bp
  • A to G, chromosome 17 at 49,671,136 bp
  • A to G, chromosome 17 at 56,663,419 bp
  • A to G, chromosome 17 at 84,557,481 bp
  • A to T, chromosome 18 at 31,443,737 bp
  • A to G, chromosome 18 at 37,767,578 bp
  • G to A, chromosome 18 at 58,020,390 bp
  • G to A, chromosome 18 at 84,562,770 bp
  • C to A, chromosome 19 at 32,125,297 bp
  • A to T, chromosome 19 at 40,071,546 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8487 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067930-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.