Strain Name:
C57BL/6J-MtgxR8674Btlr/Mmmh
Stock Number:
068529-MU
Citation ID:
RRID:MMRRC_068529-MU
Other Names:
R8674 (G1)
Major Collection:

Strain Information

Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: Hip14, D130071N24Rik, A230053P19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Lgals8
Name: lectin, galactose binding, soluble 8
Synonyms: 1200015E08Rik, D13Ertd524e, Lgals-8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56048
HGNC: HGNC:6569
Homologene: 31386
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245945
Homologene: 36932
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Gpr56, Cyt28
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: e-LOX2, Aloxe2, 12R-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain IIB, SMemb, NMHC-B, nonmuscle myosin heavy chain II-B, Myhn-2, 5730504C04Rik, myosin IIB, Fltn, Myhn2, Fltn, NMHC II-B, Myosin IIB, 9330167F11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: 2310022G15Rik, 5033407O22Rik, 4833414K03Rik, CHAK1, LTRPC7, CHAK, TRP-PLIK, Ltpr7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Listerin, Zfp294, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: Duplin, 5830451P18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Csgalnact1
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Synonyms: 4732435N03Rik, CSGalNAcT-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234356
Homologene: 23099
Nck1
Name: non-catalytic region of tyrosine kinase adaptor protein 1
Synonyms: D230010O13Rik, 6330586M15Rik, Nck
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17973
HGNC: HGNC:7664
Homologene: 38148
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Zimp10, Rai17
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328365
Homologene: 10667
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232875
Homologene: 122136
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Or10d1
Name: olfactory receptor family 10 subfamily D member 1
Synonyms: Olfr959, GA_x6K02T2PVTD-33270211-33269276, MOR224-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258501
VEGA: 9
Homologene: 71989
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, SKIP, A930009L15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Cyp4a29
Name: cytochrome P450, family 4, subfamily a, polypeptide 29
Synonyms: Cyp4a29-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230639
Hmgxb3
Name: HMG box domain containing 3
Synonyms: 2510002C16Rik, A630042L21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106894
VEGA: 18
Homologene: 44229
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Or10x4
Name: olfactory receptor family 10 subfamily X member 4
Synonyms: GA_x6K02T2P20D-20771141-20770212, GA_x6K02T2MFC0-1145-1312, Olfr248, MOR267-7, Olfr415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258709
Or4c103
Name: olfactory receptor family 4 subfamily C member 103
Synonyms: Olfr1195, GA_x6K02T2Q125-50163514-50162588, MOR230-12_p, MOR230-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258748
Homologene: 103782
Or10d3
Name: olfactory receptor family 10 subfamily D member 3
Synonyms: MOR224-9, Olfr958, GA_x6K02T2PVTD-33247839-33246901
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258327
VEGA: 9
HGNC: HGNC:8168
Homologene: 27128
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240675
Homologene: 18238
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: RIP11, GAF1, 9130206P09Rik, D6Ertd32e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52055
Homologene: 9158
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6as, Six6os1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75801
Homologene: 49922
Nsun5
Name: NOL1/NOP2/Sun domain family, member 5
Synonyms: Nol1r, 9830109N13Rik, Wbscr20a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100609
Homologene: 6828
Spint4
Name: serine protease inhibitor, Kunitz type 4
Synonyms: 9230105I15Rik, Spint4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78239
Homologene: 49932
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Rpl12
Name: ribosomal protein L12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269261
Homologene: 128047
Defb47
Name: defensin beta 47
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 654465
Homologene: 86859
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 83,277,844 bp
  • A to G, chromosome 1 at 174,391,692 bp
  • G to C, chromosome 2 at 26,395,034 bp
  • T to A, chromosome 2 at 32,962,110 bp
  • T to A, chromosome 2 at 88,683,430 bp
  • T to C, chromosome 2 at 126,799,166 bp
  • T to A, chromosome 2 at 164,700,982 bp
  • A to T, chromosome 4 at 115,249,685 bp
  • C to T, chromosome 4 at 141,470,370 bp
  • T to A, chromosome 5 at 66,019,399 bp
  • T to C, chromosome 5 at 94,537,746 bp
  • C to A, chromosome 5 at 135,371,540 bp
  • C to T, chromosome 5 at 144,791,032 bp
  • T to A, chromosome 6 at 85,341,928 bp
  • A to G, chromosome 6 at 142,430,322 bp
  • T to C, chromosome 7 at 8,377,823 bp
  • T to C, chromosome 7 at 12,770,900 bp
  • A to G, chromosome 8 at 68,373,616 bp
  • A to T, chromosome 8 at 95,000,898 bp
  • A to G, chromosome 9 at 39,550,379 bp
  • T to C, chromosome 9 at 39,572,953 bp
  • T to C, chromosome 9 at 100,508,527 bp
  • T to A, chromosome 9 at 106,863,697 bp
  • C to A, chromosome 9 at 119,178,401 bp
  • A to G, chromosome 10 at 110,949,679 bp
  • A to G, chromosome 11 at 30,139,352 bp
  • A to G, chromosome 11 at 68,814,431 bp
  • A to G, chromosome 11 at 69,163,975 bp
  • T to C, chromosome 11 at 97,335,047 bp
  • T to C, chromosome 12 at 72,909,922 bp
  • A to G, chromosome 12 at 103,596,461 bp
  • A to T, chromosome 13 at 12,447,236 bp
  • A to G, chromosome 14 at 25,646,986 bp
  • T to C, chromosome 14 at 52,213,006 bp
  • T to C, chromosome 14 at 62,998,130 bp
  • C to A, chromosome 15 at 85,862,175 bp
  • A to C, chromosome 16 at 87,398,785 bp
  • G to A, chromosome 18 at 61,136,231 bp
  • T to C, chromosome 19 at 9,005,996 bp
  • A to G, chromosome 19 at 56,886,995 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8674 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068529-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.