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Strain Name:
C57BL/6J-MtgxR9585Btlr/Mmmh
Stock Number:
069378-MU
Citation ID:
RRID:MMRRC_069378-MU
Other Names:
R9585 (G1)
Major Collection:

Strain Information

Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Setd3
Name: SET domain containing 3
Synonyms: 2610305M23Rik, D12Ertd771e, 2610102I01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52690
Homologene: 41748
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 67,156,182 bp (GRCm38)
  • A to G, chromosome 1 at 71,303,586 bp (GRCm38)
  • A to T, chromosome 1 at 170,922,299 bp (GRCm38)
  • A to G, chromosome 2 at 76,524,094 bp (GRCm38)
  • T to A, chromosome 2 at 87,962,575 bp (GRCm38)
  • T to C, chromosome 2 at 143,957,559 bp (GRCm38)
  • T to C, chromosome 3 at 33,005,942 bp (GRCm38)
  • T to A, chromosome 3 at 124,406,344 bp (GRCm38)
  • A to T, chromosome 4 at 126,317,993 bp (GRCm38)
  • G to T, chromosome 4 at 136,938,586 bp (GRCm38)
  • G to T, chromosome 4 at 151,012,681 bp (GRCm38)
  • A to G, chromosome 5 at 5,581,269 bp (GRCm38)
  • T to C, chromosome 5 at 26,086,544 bp (GRCm38)
  • T to A, chromosome 5 at 38,092,572 bp (GRCm38)
  • T to C, chromosome 5 at 114,897,840 bp (GRCm38)
  • G to A, chromosome 5 at 144,840,520 bp (GRCm38)
  • T to A, chromosome 6 at 3,600,348 bp (GRCm38)
  • T to A, chromosome 6 at 56,757,314 bp (GRCm38)
  • A to T, chromosome 7 at 92,661,798 bp (GRCm38)
  • T to A, chromosome 7 at 108,868,345 bp (GRCm38)
  • T to C, chromosome 8 at 120,174,711 bp (GRCm38)
  • T to C, chromosome 9 at 27,322,236 bp (GRCm38)
  • A to T, chromosome 9 at 35,543,713 bp (GRCm38)
  • T to C, chromosome 9 at 50,579,361 bp (GRCm38)
  • T to A, chromosome 9 at 110,744,779 bp (GRCm38)
  • C to A, chromosome 10 at 28,493,151 bp (GRCm38)
  • G to A, chromosome 10 at 78,713,360 bp (GRCm38)
  • A to G, chromosome 10 at 103,215,389 bp (GRCm38)
  • T to G, chromosome 11 at 8,854,390 bp (GRCm38)
  • C to A, chromosome 11 at 59,075,005 bp (GRCm38)
  • T to A, chromosome 11 at 65,204,366 bp (GRCm38)
  • A to G, chromosome 11 at 69,034,664 bp (GRCm38)
  • T to A, chromosome 11 at 77,818,669 bp (GRCm38)
  • G to A, chromosome 11 at 100,104,066 bp (GRCm38)
  • A to G, chromosome 11 at 102,357,089 bp (GRCm38)
  • A to T, chromosome 12 at 83,967,698 bp (GRCm38)
  • A to C, chromosome 12 at 108,108,555 bp (GRCm38)
  • A to G, chromosome 13 at 55,524,244 bp (GRCm38)
  • T to C, chromosome 13 at 95,985,958 bp (GRCm38)
  • A to T, chromosome 13 at 100,300,069 bp (GRCm38)
  • A to T, chromosome 14 at 24,452,221 bp (GRCm38)
  • G to T, chromosome 14 at 59,331,255 bp (GRCm38)
  • A to G, chromosome 14 at 118,235,581 bp (GRCm38)
  • C to T, chromosome 16 at 10,886,119 bp (GRCm38)
  • A to G, chromosome 16 at 19,241,210 bp (GRCm38)
  • G to A, chromosome 17 at 24,400,512 bp (GRCm38)
  • A to G, chromosome 17 at 74,609,270 bp (GRCm38)
  • T to C, chromosome 18 at 46,878,344 bp (GRCm38)
  • A to G, chromosome 19 at 9,113,034 bp (GRCm38)
  • A to G, chromosome 19 at 42,052,913 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9585 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069378-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.