Strain Name:
C57BL/6J-MtgxR0220Btlr/Mmmh
Stock Number:
038469-MU
Citation ID:
RRID:MMRRC_038469-MU
Other Names:
R0220 (G1), C57BL/6J-MtgxR0220Btlr
Major Collection:

Strain Information

Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20349
Homologene: 8247
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Tpgs1
Name: tubulin polyglutamylase complex subunit 1
Synonyms: Gm16517, Gtrgeo22
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110012
VEGA: 10
Homologene: 17525
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109079
Homologene: 56558
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: KMT4, mDot1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Kiaa1064-hp, Bwq1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330474
Homologene: 87150
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67812
Homologene: 40962
Arpc2
Name: actin related protein 2/3 complex, subunit 2
Synonyms: 2210023N03Rik, p34-Arc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76709
HGNC: HGNC:705
Homologene: 4187
Bcl7a
Name: B cell CLL/lymphoma 7A
Synonyms: 4432415N06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77045
HGNC: HGNC:1004
Homologene: 10869
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: 2900011L11Rik, Abcc5a, Abcc5b, Mrp5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67211
Homologene: 12097
Bcl6
Name: B cell leukemia/lymphoma 6
Synonyms: Bcl5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12053
HGNC: HGNC:1001
Homologene: 7640
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Ass1
Name: argininosuccinate synthetase 1
Synonyms: fold, ASS, Ass-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: LOC380777, skNAC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Anxa6
Name: annexin A6
Synonyms: Annexin VI, Cabm, Anx6, AnxVI, Camb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Zfp81
Name: zinc finger protein 81
Synonyms: Zfp78, C330034P10Rik, D330034E10Rik, Hszfp36, KRAB13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224694
Homologene: 138633
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: B430305I03Rik, MD44, MTSG1, Atip1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102103
Homologene: 100292
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Prom2
Name: prominin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192212
Homologene: 44536
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Cxxc8, Fbxl11, Jhdm1a, Fbl7, lalina, 5530401A10Rik, Gm4560
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: mRib72-1, myoclonin1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 6030439O22Rik, D12Ertd19e, 1700081O04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73490
Homologene: 16340
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Dennd4a
Name: DENN domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Dcdc5
Name: doublecortin domain containing 5
Synonyms: 4732421G10Rik, EG436559
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329482
Homologene: 79722
Krt34
Name: keratin 34
Synonyms: 4733401E01Rik, Krt1-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16672
HGNC: HGNC:6452
Homologene: 31083
Cgnl1
Name: cingulin-like 1
Synonyms: Jacop, 9930020M10Rik, 4933421H10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68178
Homologene: 41901
Opn5
Name: opsin 5
Synonyms: Neuropsin, Gpr136, TMEM13, PGR12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353344
VEGA: 17
Homologene: 72341
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 214321
Homologene: 86950
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Cyp4f13
Name: cytochrome P450, family 4, subfamily f, polypeptide 13
Synonyms: 0610030I10Rik, P450 CYP4F13, leukotriene B4 omega hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 170716
HGNC: HGNC:2646
Homologene: 73902
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Or4c126
Name: olfactory receptor family 4 subfamily C member 126
Synonyms: GA_x6K02T2Q125-51425355-51426275, Olfr1261, MOR234-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258466
Homologene: 138310
Ip6k3
Name: inositol hexaphosphate kinase 3
Synonyms: Ihpk3, D830007E07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 271424
Homologene: 65257
Hsdl2
Name: hydroxysteroid dehydrogenase like 2
Synonyms: 2610207I16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72479
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: OTTMUSG00000020811, A116
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 613123
Lcn11
Name: lipocalin 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227630
Homologene: 129702
Traf1
Name: TNF receptor-associated factor 1
Synonyms: 4732496E14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22029
Homologene: 4138
Kbtbd10
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Pilrb2
Name: paired immunoglobin-like type 2 receptor beta 2
Synonyms: EG545812
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545812
Homologene: 114502
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Akr1d1
Name: aldo-keto reductase family 1, member D1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 208665
HGNC: HGNC:388
Homologene: 55943
Uevld
Name: UEV and lactate/malate dehyrogenase domains
Synonyms: 8430408E05Rik, Attp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54122
Homologene: 69251
Zfp963
Name: zinc finger protein 963
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 620419
Homologene: 49795
Kdm4d
Name: lysine (K)-specific demethylase 4D
Synonyms: Jmjd2d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244694
Homologene: 69244
Foxred1
Name: FAD-dependent oxidoreductase domain containing 1
Synonyms: TEG-23, Tex23
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235169
Homologene: 9712
P2rx1
Name: purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms: RP-2, P2X1 receptor, P2x, Pdcd3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18436
HGNC: HGNC:8533
Homologene: 1921
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268465
Homologene: 16123
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Or5h22
Name: olfactory receptor family 5 subfamily H member 22
Synonyms: GA_x54KRFPKG5P-55303207-55302284, MOR183-4, Olfr190
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258392
Homologene: 131129
Ccnj
Name: cyclin J
Synonyms: D430039C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240665
Homologene: 10413
Pcgf6
Name: polycomb group ring finger 6
Synonyms: Rnf134, 4933407A11Rik, MBLR, Mel18 and Bmi1-like RING finger protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71041
VEGA: 19
Homologene: 12378
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: Bpag, BP180, BPAg2, Bpag2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,967,358 bp
  • T to A, chromosome 1 at 74,248,134 bp
  • A to T, chromosome 1 at 88,088,335 bp
  • T to A, chromosome 1 at 128,256,194 bp
  • A to G, chromosome 2 at 4,899,560 bp
  • C to A, chromosome 2 at 13,356,709 bp
  • A to T, chromosome 2 at 25,777,831 bp
  • A to T, chromosome 2 at 31,514,819 bp
  • A to T, chromosome 2 at 34,949,103 bp
  • G to A, chromosome 2 at 69,670,485 bp
  • T to C, chromosome 2 at 76,811,393 bp
  • G to T, chromosome 2 at 89,993,862 bp
  • A to G, chromosome 2 at 106,357,026 bp
  • A to C, chromosome 2 at 127,541,107 bp
  • A to T, chromosome 2 at 150,268,675 bp
  • G to A, chromosome 3 at 56,005,303 bp
  • G to A, chromosome 3 at 159,523,905 bp
  • T to A, chromosome 4 at 59,612,677 bp
  • A to T, chromosome 4 at 82,296,776 bp
  • G to A, chromosome 4 at 154,258,215 bp
  • T to C, chromosome 5 at 14,164,153 bp
  • T to C, chromosome 5 at 20,540,002 bp
  • A to G, chromosome 5 at 21,661,584 bp
  • A to T, chromosome 5 at 109,156,466 bp
  • G to A, chromosome 5 at 123,351,919 bp
  • C to A, chromosome 5 at 137,871,197 bp
  • G to A, chromosome 5 at 146,098,270 bp
  • A to G, chromosome 6 at 37,554,614 bp
  • T to C, chromosome 7 at 16,429,273 bp
  • G to A, chromosome 7 at 46,955,523 bp
  • A to T, chromosome 7 at 110,124,526 bp
  • A to T, chromosome 8 at 40,994,572 bp
  • A to T, chromosome 8 at 69,743,493 bp
  • A to T, chromosome 8 at 69,743,495 bp
  • G to T, chromosome 8 at 99,111,679 bp
  • G to A, chromosome 8 at 122,486,956 bp
  • A to T, chromosome 9 at 14,463,122 bp
  • A to G, chromosome 9 at 35,209,453 bp
  • A to C, chromosome 9 at 64,852,445 bp
  • C to A, chromosome 9 at 71,724,943 bp
  • A to G, chromosome 9 at 122,749,303 bp
  • T to A, chromosome 10 at 79,675,437 bp
  • A to T, chromosome 10 at 80,785,858 bp
  • T to C, chromosome 10 at 128,043,386 bp
  • A to T, chromosome 10 at 128,483,636 bp
  • A to C, chromosome 11 at 54,981,762 bp
  • G to T, chromosome 11 at 72,865,966 bp
  • A to T, chromosome 11 at 73,009,926 bp
  • T to A, chromosome 11 at 94,650,258 bp
  • C to T, chromosome 11 at 100,038,693 bp
  • A to G, chromosome 11 at 119,544,641 bp
  • C to A, chromosome 12 at 16,682,286 bp
  • A to G, chromosome 12 at 57,457,150 bp
  • T to C, chromosome 12 at 71,148,420 bp
  • G to T, chromosome 12 at 81,378,648 bp
  • A to T, chromosome 12 at 112,157,390 bp
  • T to A, chromosome 13 at 62,774,457 bp
  • A to G, chromosome 16 at 20,369,102 bp
  • G to T, chromosome 16 at 20,598,282 bp
  • T to A, chromosome 16 at 23,966,219 bp
  • A to T, chromosome 16 at 59,074,732 bp
  • A to T, chromosome 17 at 27,145,229 bp
  • A to G, chromosome 17 at 32,929,502 bp
  • A to G, chromosome 17 at 33,336,724 bp
  • A to G, chromosome 17 at 42,596,604 bp
  • T to C, chromosome 19 at 4,324,919 bp
  • T to C, chromosome 19 at 40,844,810 bp
  • A to G, chromosome 19 at 47,040,090 bp
  • T to C, chromosome 19 at 47,080,560 bp
  • C to A, chromosome 19 at 47,652,644 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0220 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038469-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.