Strain Name:
C57BL/6J-MtgxR0619Btlr/Mmmh
Stock Number:
038808-MU
Citation ID:
RRID:MMRRC_038808-MU
Other Names:
R0619 (G1), C57BL/6J-MtgxR0619Btlr
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Sbf2
Name: SET binding factor 2
Synonyms: B430219L04Rik, mMTMH1, 4833411B01Rik, SBF2, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Tagln3
Name: transgelin 3
Synonyms: 2900005O10Rik, 2700038H05Rik, Np25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56370
Homologene: 22337
Stub1
Name: STIP1 homology and U-Box containing protein 1
Synonyms: 0610033N24Rik, CHIP, 2310040B03Rik, 2210017D18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56424
VEGA: 17
Homologene: 4281
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: NICE-4, 4932431F02Rik, A430103N23Rik, 3110083O19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74383
Homologene: 136291
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1700086G08Rik, 1810060J02Rik, p56
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67015
Homologene: 10131
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: NY-REN-45, 4930438A20Rik, E330032J19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226823
Homologene: 9395
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB90, G630013P12Rik, TFC5, TAF3B1, B130055N23Rik, Tfnr, TFIIIB150
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Acbd6
Name: acyl-Coenzyme A binding domain containing 6
Synonyms: 2610100E10Rik, 0610010G04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72482
Homologene: 12465
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 9330188B09Rik, D630001M17Rik, 4921513O20Rik, LOC381026
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16769
Homologene: 65341
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Gnb4
Name: guanine nucleotide binding protein (G protein), beta 4
Synonyms: 6720453A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14696
Homologene: 69140
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22325
Homologene: 2530
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 1200013I08Rik, 5730419H05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74132
Homologene: 14036
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: SH2-containing Eph receptor-binding protein 1, Nsp3, Shep1, Chat, Cas/HEF1-associated signal transducer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27387
Homologene: 69145
Siglech
Name: sialic acid binding Ig-like lectin H
Synonyms: Siglec-H, 6430529G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233274
Homologene: 48041
Rspo3
Name: R-spondin 3
Synonyms: Thsd2, Cristin1, 2810459H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72780
VEGA: 10
Homologene: 12484
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Apn, aminopeptidase N, Cd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Trappc14
Name: trafficking protein particle complex 14
Synonyms: BC037034, Map11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231807
Homologene: 10106
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Bbs7
Name: Bardet-Biedl syndrome 7
Synonyms: 8430406N16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71492
Homologene: 12395
Ces2a
Name: carboxylesterase 2A
Synonyms: 9130231C15Rik, Ces6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Or2aj5
Name: olfactory receptor family 2 subfamily AJ member 5
Synonyms: MOR273-2, GA_x54KRFPKG5P-16052703-16051765, Olfr170
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258959
Homologene: 128058
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Kcnn3
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms: SK3, small conductance calcium-activated potassium channel 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140493
HGNC: HGNC:6292
Homologene: 20516
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a2, Cav1.3alpha1, 8430418G19Rik, Cchl1a, D-LTCC, Cacnl1a2, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: Ube1dc1, 5730525G14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66663
Homologene: 11738
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: D17Ertd479e, Emr4, Gpr127, FIRE, EGF-TM7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, 2810043H12Rik, mSNM1, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap1a, Mtap-1, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, PLCeta2, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Mss51
Name: MSS51 mitochondrial translational activator
Synonyms: Zmynd17, 4833444M15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74843
VEGA: 14
Homologene: 27997
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Iqsec1
Name: IQ motif and Sec7 domain 1
Synonyms: BRAG2, cI-43, D6Ertd349e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232227
Homologene: 82429
Tsks
Name: testis-specific serine kinase substrate
Synonyms: Tssks1, Stk22s1, Tsks, clone 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22116
Homologene: 7984
C2
Name: complement C2
Synonyms: classical-complement pathway C3/C5 convertase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12263
HGNC: HGNC:1248
Homologene: 45
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: March10, 4933417C16Rik, Rnf190, OTTMUSG00000002847
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 632687
Homologene: 34988
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237926
Homologene: 41252
Ptpru
Name: protein tyrosine phosphatase receptor type U
Synonyms: RPTPlambda, Ptprl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Mtmr10
Name: myotubularin related protein 10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233315
Homologene: 9822
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 1200004E02Rik, UBP-M, 2810483I07Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Or5m9
Name: olfactory receptor family 5 subfamily M member 9
Synonyms: Olfr1034, Olfr1533-ps1, MOR245-14P, GA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR227-8P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258216
Homologene: 51741
Mup3
Name: major urinary protein 3
Synonyms: Mup-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17842
Homologene: 74304
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: D8Ertd91e, 2310066G09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52065
Homologene: 3114
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75773
Homologene: 16392
Hyal3
Name: hyaluronoglucosaminidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109685
HGNC: HGNC:5322
Homologene: 2626
Slc16a11
Name: solute carrier family 16 (monocarboxylic acid transporters), member 11
Synonyms: MNCb-2717
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216867
Homologene: 27409
Amdhd2
Name: amidohydrolase domain containing 2
Synonyms: 5730457F11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 245847
Homologene: 9311
Or1o2
Name: olfactory receptor family 1 subfamily O member 2
Synonyms: Olfr97, MOR156-2, GA_x6K02T2PSCP-1672287-1671355
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258505
Homologene: 133051
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 155,558,872 bp
  • T to C, chromosome 1 at 188,978,643 bp
  • A to G, chromosome 2 at 27,296,121 bp
  • T to C, chromosome 2 at 30,409,984 bp
  • T to A, chromosome 2 at 32,753,025 bp
  • T to A, chromosome 2 at 82,944,140 bp
  • T to A, chromosome 2 at 86,047,311 bp
  • T to A, chromosome 2 at 121,305,255 bp
  • T to C, chromosome 2 at 155,611,722 bp
  • C to A, chromosome 2 at 157,265,081 bp
  • C to T, chromosome 3 at 32,591,207 bp
  • A to G, chromosome 3 at 36,607,576 bp
  • A to C, chromosome 3 at 89,652,030 bp
  • A to C, chromosome 3 at 90,017,220 bp
  • T to C, chromosome 4 at 62,085,961 bp
  • C to T, chromosome 4 at 131,820,887 bp
  • C to T, chromosome 4 at 154,985,407 bp
  • G to A, chromosome 5 at 25,298,916 bp
  • T to C, chromosome 5 at 29,667,908 bp
  • T to C, chromosome 5 at 73,068,731 bp
  • A to G, chromosome 5 at 108,180,416 bp
  • A to G, chromosome 5 at 138,263,826 bp
  • G to A, chromosome 5 at 146,210,721 bp
  • T to C, chromosome 6 at 90,670,406 bp
  • C to T, chromosome 6 at 147,590,566 bp
  • A to G, chromosome 7 at 44,950,834 bp
  • A to T, chromosome 7 at 55,769,162 bp
  • G to A, chromosome 7 at 64,321,213 bp
  • T to C, chromosome 7 at 79,841,009 bp
  • T to A, chromosome 7 at 110,310,262 bp
  • C to A, chromosome 7 at 127,406,541 bp
  • T to A, chromosome 7 at 130,716,753 bp
  • T to A, chromosome 8 at 35,590,675 bp
  • G to A, chromosome 8 at 95,102,665 bp
  • T to A, chromosome 8 at 104,736,110 bp
  • G to A, chromosome 8 at 119,613,000 bp
  • A to G, chromosome 9 at 104,049,221 bp
  • A to G, chromosome 9 at 107,585,672 bp
  • T to C, chromosome 10 at 29,504,637 bp
  • C to T, chromosome 10 at 60,433,777 bp
  • T to C, chromosome 10 at 106,474,894 bp
  • T to C, chromosome 10 at 115,420,810 bp
  • A to G, chromosome 10 at 127,120,991 bp
  • G to T, chromosome 11 at 70,215,032 bp
  • C to T, chromosome 11 at 94,542,639 bp
  • A to T, chromosome 11 at 105,389,576 bp
  • A to G, chromosome 11 at 115,815,064 bp
  • A to G, chromosome 12 at 105,733,511 bp
  • T to C, chromosome 13 at 100,037,858 bp
  • A to T, chromosome 14 at 20,487,573 bp
  • G to T, chromosome 14 at 30,072,034 bp
  • T to C, chromosome 15 at 44,483,838 bp
  • T to C, chromosome 15 at 58,662,935 bp
  • T to C, chromosome 15 at 91,726,316 bp
  • T to A, chromosome 16 at 19,606,272 bp
  • T to A, chromosome 16 at 36,759,307 bp
  • C to A, chromosome 16 at 45,724,272 bp
  • A to T, chromosome 16 at 87,472,164 bp
  • T to C, chromosome 17 at 24,156,588 bp
  • T to C, chromosome 17 at 25,831,322 bp
  • G to T, chromosome 17 at 34,872,503 bp
  • T to A, chromosome 17 at 37,232,155 bp
  • T to A, chromosome 17 at 55,820,679 bp
  • T to C, chromosome 18 at 20,461,359 bp
  • T to C, chromosome 19 at 15,978,862 bp
  • A to T, chromosome 19 at 56,545,409 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0619 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038808-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.