Strain Name:
C57BL/6J-MtgxR1615Btlr/Mmmh
Stock Number:
039652-MU
Citation ID:
RRID:MMRRC_039652-MU
Other Names:
R1615 (G1), C57BL/6J-MtgxR1615Btlr
Major Collection:

Strain Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, KHS, 4432415E19Rik, GCKR
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, rcw, Grm1, Gprc1a, nmf373, 4930455H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ndfip1
Name: Nedd4 family interacting protein 1
Synonyms: 0610010M22Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 65113
VEGA: 18
Homologene: 12730
Scrib
Name: scribbled planar cell polarity
Synonyms: Crc, Scrb1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Bzw2
Name: basic leucine zipper and W2 domains 2
Synonyms: HSPC028, 1110001I24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66912
VEGA: 12
Homologene: 8530
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Tent3a, 9230115F04Rik, Zcchc11, 6030404K05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230594
Homologene: 35279
Arid2
Name: AT-rich interaction domain 2
Synonyms: zipzap/p200, 1700124K17Rik, 4432409D24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Lrrc1
Name: leucine rich repeat containing 1
Synonyms: A430093J20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214345
Homologene: 44445
Aen
Name: apoptosis enhancing nuclease
Synonyms: Isg20l1, 2700083B06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68048
Homologene: 23382
Myo9a
Name: myosin IXa
Synonyms: C130068I12Rik, 4732465J09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Hey1
Name: hairy/enhancer-of-split related with YRPW motif 1
Synonyms: CHF2, HRT1, bHLHb31, Herp2, hesr-1, Hesr1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15213
HGNC: HGNC:4880
Homologene: 7756
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Spink6
Name: serine peptidase inhibitor, Kazal type 6
Synonyms: EG433180
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433180
VEGA: 18
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: 9830001H06Rik, D430036N24Rik, Soga1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 435684
Homologene: 44524
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67498
VEGA: 15
Homologene: 22811
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Ccr1
Name: C-C motif chemokine receptor 1
Synonyms: Cmkbr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12768
VEGA: 9
HGNC: HGNC:1602
Homologene: 20344
Myo6
Name: myosin VI
Synonyms: Myo6rsv, rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: Flt-1, VEGFR1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234686
Homologene: 136406
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Plcb1
Name: phospholipase C, beta 1
Synonyms: 3110043I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18795
Homologene: 22876
Nlrp14
Name: NLR family, pyrin domain containing 14
Synonyms: GC-LRR, 4921520L01Rik, Nalp14, Nalp-iota
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76858
Homologene: 18531
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Vsig8
Name: V-set and immunoglobulin domain containing 8
Synonyms: EG240916
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240916
Homologene: 18616
Trim30a
Name: tripartite motif-containing 30A
Synonyms: Trim30, Rpt-1, Rpt1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20128
Homologene: 114426
Trim60
Name: tripartite motif-containing 60
Synonyms: 2czf45, Rnf33
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234329
Homologene: 51876
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228094
Homologene: 52396
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320082
Homologene: 110776
Amer3
Name: APC membrane recruitment 3
Synonyms: Fam123c, 9430069J07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211383
Homologene: 51888
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207742
Homologene: 37742
Tgfbrap1
Name: transforming growth factor, beta receptor associated protein 1
Synonyms: 3110018K12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73122
Homologene: 3141
Tdpoz3
Name: TD and POZ domain containing 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399674
Homologene: 128308
Itga2b
Name: integrin alpha 2b
Synonyms: GpIIb, alphaIIb, CD41, GP IIb, platelet glycoprotein IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: bv, nSR100, 1500001A10Rik, flopsy, B230202K19Rik, fp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Vmn1r81
Name: vomeronasal 1 receptor 81
Synonyms: V1rg9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171244
Homologene: 74327
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
Esp36
Name: exocrine gland secreted peptide 36
Synonyms: Gm20408
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126765
Lmcd1
Name: LIM and cysteine-rich domains 1
Synonyms: dyxin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30937
HGNC: HGNC:6633
Homologene: 22823
Insyn1
Name: inhibitory synaptic factor 1
Synonyms: 6030419C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319477
VEGA: 9
Homologene: 18538
Tada2a
Name: transcriptional adaptor 2A
Synonyms: Tada2l, D030022J10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217031
Homologene: 38834
Neurl3
Name: neuralized E3 ubiquitin protein ligase 3
Synonyms: Lincr, 2010300P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214854
Homologene: 35002
Saraf
Name: store-operated calcium entry-associated regulatory factor
Synonyms: Tmem66, 1810045K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67887
Homologene: 9398
Slc35g3
Name: solute carrier family 35, member G3
Synonyms: Amac1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56293
Homologene: 89413
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: Gpr80, Cysltr3, LOC239283, P2Y15, Gpr99
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
Stfa1
Name: stefin A1
Synonyms: Stf1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20861
VEGA: 16
HGNC: HGNC:2481
Homologene: 104045
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,199,371 bp
  • T to C, chromosome 1 at 34,588,171 bp
  • T to C, chromosome 1 at 36,269,389 bp
  • A to G, chromosome 1 at 40,006,830 bp
  • A to G, chromosome 1 at 43,051,985 bp
  • A to G, chromosome 1 at 160,118,408 bp
  • A to G, chromosome 1 at 172,559,713 bp
  • A to G, chromosome 2 at 53,118,424 bp
  • A to T, chromosome 2 at 79,342,236 bp
  • T to C, chromosome 2 at 122,349,432 bp
  • A to T, chromosome 2 at 135,362,444 bp
  • T to G, chromosome 2 at 157,020,743 bp
  • A to T, chromosome 3 at 8,664,838 bp
  • C to A, chromosome 3 at 93,826,311 bp
  • A to G, chromosome 4 at 3,748,765 bp
  • T to C, chromosome 4 at 108,542,000 bp
  • G to A, chromosome 4 at 141,922,323 bp
  • G to T, chromosome 5 at 24,875,178 bp
  • A to G, chromosome 5 at 116,447,300 bp
  • A to G, chromosome 5 at 147,639,288 bp
  • A to G, chromosome 6 at 112,273,950 bp
  • T to A, chromosome 7 at 12,260,514 bp
  • T to C, chromosome 7 at 78,905,912 bp
  • A to T, chromosome 7 at 104,412,327 bp
  • A to G, chromosome 7 at 105,703,206 bp
  • T to A, chromosome 7 at 105,713,706 bp
  • A to T, chromosome 7 at 107,196,163 bp
  • A to G, chromosome 7 at 110,273,291 bp
  • A to G, chromosome 7 at 125,820,198 bp
  • A to G, chromosome 8 at 34,165,288 bp
  • A to T, chromosome 8 at 65,000,510 bp
  • C to T, chromosome 8 at 105,347,831 bp
  • C to T, chromosome 9 at 58,499,068 bp
  • A to G, chromosome 9 at 59,788,456 bp
  • T to C, chromosome 9 at 77,435,118 bp
  • C to T, chromosome 9 at 80,307,725 bp
  • T to C, chromosome 9 at 109,143,726 bp
  • T to C, chromosome 9 at 123,963,536 bp
  • G to T, chromosome 10 at 10,741,508 bp
  • T to A, chromosome 10 at 59,131,077 bp
  • T to A, chromosome 10 at 74,450,147 bp
  • A to G, chromosome 11 at 59,099,825 bp
  • A to G, chromosome 11 at 69,760,542 bp
  • T to C, chromosome 11 at 84,103,100 bp
  • C to T, chromosome 11 at 87,731,659 bp
  • C to T, chromosome 11 at 102,460,137 bp
  • A to G, chromosome 12 at 36,119,127 bp
  • A to T, chromosome 12 at 69,844,413 bp
  • A to G, chromosome 12 at 118,050,722 bp
  • G to T, chromosome 13 at 81,424,288 bp
  • G to A, chromosome 14 at 33,042,512 bp
  • A to T, chromosome 14 at 120,022,773 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • A to T, chromosome 15 at 64,871,776 bp
  • T to C, chromosome 15 at 76,066,205 bp
  • C to T, chromosome 15 at 96,371,654 bp
  • T to G, chromosome 16 at 36,280,467 bp
  • A to G, chromosome 17 at 38,419,439 bp
  • A to G, chromosome 17 at 74,609,409 bp
  • C to T, chromosome 18 at 38,460,619 bp
  • T to A, chromosome 18 at 44,083,369 bp
  • A to G, chromosome 19 at 41,650,671 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1615 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039652-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.