Strain Name:
C57BL/6J-MtgxR1633Btlr/Mmmh
Stock Number:
039670-MU
Citation ID:
RRID:MMRRC_039670-MU
Other Names:
R1633 (G1), C57BL/6J-MtgxR1633Btlr
Major Collection:

Strain Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: E430025J12Rik, Nedd4-1, Nedd4, Nedd4a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Pax6
Name: paired box 6
Synonyms: Gsfaey11, Dickie's small eye, AEY11, 1500038E17Rik, Pax-6, Dey
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18508
HGNC: HGNC:8620
Homologene: 1212
Bpifb3
Name: BPI fold containing family B, member 3
Synonyms: Rya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 378700
Homologene: 18807
Ess2
Name: ess-2 splicing factor
Synonyms: ES2, Dgsi, Dgcr14, D16H22S1269E, Es2el
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27886
VEGA: 16
Homologene: 11184
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: nmf2, nur14, C630029C19Rik, seal, med, motor end-plate disease, ataxia 3, nmf335, mnd2, mnd-2, nmf58, NaCh6, NMF335, Nav1.6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, 2610509D04Rik, Bchs, Ggtb3, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ccar1
Name: cell division cycle and apoptosis regulator 1
Synonyms: 2610511G16Rik, 9430036H15Rik, Carp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67500
VEGA: 10
Homologene: 10086
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F37S1, D7H15F32S1, rjs, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Mrell, Rad50l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Zfp180
Name: zinc finger protein 180
Synonyms: HHZ168, D130011P11, 2310040I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Stk3
Name: serine/threonine kinase 3
Synonyms: Ste20, 0610042I06Rik, Mst2, MST, mess1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56274
Homologene: 48420
Arel1
Name: apoptosis resistant E3 ubiquitin protein ligase 1
Synonyms: 1110018G07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68497
Homologene: 8885
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Srf
Name: serum response factor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20807
VEGA: 17
Homologene: 31135
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Galnt4
Name: polypeptide N-acetylgalactosaminyltransferase 4
Synonyms: ppGaNTase-T4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14426
Homologene: 74511
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233552
Homologene: 32741
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53614
Homologene: 9622
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Nipal3
Name: NIPA-like domain containing 3
Synonyms: Npal3, 9130020G22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74552
Homologene: 10722
Nadk
Name: NAD kinase
Synonyms: 4432404C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192185
Homologene: 49724
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Rdh10
Name: retinol dehydrogenase 10 (all-trans)
Synonyms: D1Ertd762e, 3110069K09Rik, m366Asp, 4921506A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98711
Homologene: 14061
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Dusp19
Name: dual specificity phosphatase 19
Synonyms: 5930436K22Rik, SKRP1, C79103, TS-DSP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68082
Homologene: 41565
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381693
Homologene: 124480
AC159748.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Stxbp4
Name: syntaxin binding protein 4
Synonyms: Synip, 6030470M02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20913
Homologene: 7963
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Ggt7
Name: gamma-glutamyltransferase 7
Synonyms: 1110017C11Rik, Ggtl3, 6330563L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 207182
HGNC: HGNC:4259
Homologene: 70866
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Tram2
Name: translocating chain-associating membrane protein 2
Synonyms: C330003D03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170829
Homologene: 8183
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382090
Homologene: 8930
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319719
Homologene: 131217
Cttnbp2
Name: cortactin binding protein 2
Synonyms: ORF4, 4732477G22Rik, 3010022N24Rik, Cortbp2, 9130022E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30785
Homologene: 14125
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, Cpt1, M-CPT I
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Lamc2
Name: laminin, gamma 2
Synonyms: nicein, 100kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16782
HGNC: HGNC:6493
Homologene: 4062
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Or2c1
Name: olfactory receptor family 2 subfamily C member 1
Synonyms: Olfr15, MOR256-17, OR3, GA_x54KRFPKG5P-348087-349025
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18312
HGNC: HGNC:8242
Homologene: 7459
Tspyl5
Name: testis-specific protein, Y-encoded-like 5
Synonyms: E130308C19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239364
VEGA: 15
Homologene: 14134
Gm5884
Name: predicted pseudogene 5884
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545878
AC133939.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Acsl6
Name: acyl-CoA synthetase long-chain family member 6
Synonyms: A330035H04Rik, Facl6, Lacsl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216739
Homologene: 100939
Acmsd
Name: amino carboxymuconate semialdehyde decarboxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266645
Homologene: 44520
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215008
Homologene: 9739
Or1o3
Name: olfactory receptor family 1 subfamily O member 3
Synonyms: MOR156-4, GA_x6K02T2PSCP-1703582-1702653, Olfr98
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258503
Homologene: 133051
Or1l4b
Name: olfactory receptor family 1 subfamily L member 4B
Synonyms: MOR138-7, MOR138-4P, Olfr364, GA_x6K02T2NLDC-33831282-33832243
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227794
HGNC: HGNC:8216
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: 1700007B13Rik, PDILT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71830
Homologene: 18382
Rdh12
Name: retinol dehydrogenase 12
Synonyms: A930033N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77974
Homologene: 110830
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 94111
Homologene: 10623
CAAA01066805.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
C630004L07Rik
Name: RIKEN cDNA C630004L07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 115489913
Sult2a1
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms: Std, Sth1, mSTa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20859
Homologene: 37741
Nkx2-9
Name: NK2 homeobox 9
Synonyms: Nkx2.9, tinman, Nkx-2.9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18094
Homologene: 7444
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,128,196 bp
  • A to T, chromosome 1 at 21,003,922 bp
  • C to T, chromosome 1 at 127,753,855 bp
  • A to T, chromosome 1 at 153,141,698 bp
  • T to A, chromosome 1 at 180,948,826 bp
  • T to A, chromosome 2 at 37,146,971 bp
  • T to C, chromosome 2 at 80,621,255 bp
  • A to T, chromosome 2 at 105,691,718 bp
  • A to T, chromosome 2 at 150,408,340 bp
  • T to A, chromosome 2 at 153,922,584 bp
  • C to T, chromosome 2 at 155,502,688 bp
  • A to T, chromosome 3 at 5,400,413 bp
  • T to C, chromosome 4 at 43,922,964 bp
  • C to A, chromosome 4 at 135,447,348 bp
  • T to C, chromosome 4 at 141,238,560 bp
  • C to T, chromosome 4 at 155,577,185 bp
  • T to A, chromosome 4 at 156,245,293 bp
  • A to G, chromosome 5 at 7,179,513 bp
  • T to A, chromosome 5 at 16,320,116 bp
  • A to C, chromosome 5 at 101,981,548 bp
  • G to T, chromosome 5 at 104,337,674 bp
  • A to T, chromosome 5 at 149,593,172 bp
  • G to T, chromosome 6 at 12,471,104 bp
  • A to T, chromosome 6 at 18,435,167 bp
  • A to T, chromosome 6 at 41,675,920 bp
  • A to T, chromosome 6 at 128,646,065 bp
  • A to G, chromosome 7 at 13,801,426 bp
  • A to G, chromosome 7 at 24,104,801 bp
  • G to A, chromosome 7 at 56,229,369 bp
  • T to A, chromosome 7 at 79,405,193 bp
  • T to C, chromosome 7 at 87,037,834 bp
  • T to C, chromosome 7 at 99,448,513 bp
  • T to G, chromosome 7 at 119,487,994 bp
  • T to C, chromosome 7 at 133,652,140 bp
  • T to A, chromosome 8 at 110,506,982 bp
  • T to A, chromosome 9 at 44,718,322 bp
  • G to A, chromosome 9 at 72,671,257 bp
  • T to C, chromosome 9 at 87,203,683 bp
  • A to G, chromosome 10 at 5,349,388 bp
  • T to C, chromosome 10 at 24,795,782 bp
  • T to C, chromosome 10 at 62,751,014 bp
  • T to A, chromosome 10 at 93,984,276 bp
  • T to C, chromosome 10 at 99,109,952 bp
  • C to T, chromosome 11 at 53,692,859 bp
  • T to C, chromosome 11 at 54,328,398 bp
  • A to G, chromosome 11 at 90,540,160 bp
  • T to C, chromosome 11 at 116,007,760 bp
  • T to C, chromosome 12 at 56,612,981 bp
  • A to T, chromosome 12 at 79,218,724 bp
  • A to G, chromosome 12 at 84,926,283 bp
  • T to A, chromosome 12 at 111,540,287 bp
  • A to T, chromosome 13 at 3,581,771 bp
  • G to A, chromosome 13 at 54,525,231 bp
  • T to A, chromosome 14 at 30,917,398 bp
  • T to C, chromosome 14 at 31,150,380 bp
  • T to A, chromosome 15 at 33,686,645 bp
  • T to C, chromosome 15 at 34,959,060 bp
  • T to C, chromosome 15 at 89,418,815 bp
  • A to G, chromosome 15 at 101,029,815 bp
  • A to C, chromosome 16 at 3,839,532 bp
  • A to G, chromosome 16 at 17,909,967 bp
  • A to C, chromosome 17 at 12,726,309 bp
  • T to A, chromosome 17 at 37,263,662 bp
  • A to T, chromosome 17 at 46,551,608 bp
  • A to G, chromosome 19 at 25,051,563 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1633 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.