Strain Name:
C57BL/6J-MtgxR3957Btlr/Mmmh
Stock Number:
040931-MU
Citation ID:
RRID:MMRRC_040931-MU
Other Names:
R3957 (G1), C57BL/6J-MtgxR3957Btlr
Major Collection:

Strain Information

Kera
Name: keratocan
Synonyms: CNA2, SLRR2B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1, 1110013E22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: Zfp258, 9330177P20Rik, D4Wsu24e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100177
Homologene: 5186
Nek7
Name: NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms: 2810460C19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59125
Homologene: 69340
Ell
Name: elongation factor RNA polymerase II
Synonyms: eleven-nineteen lysine-rich leukemia gene, Men, Ell1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13716
Homologene: 4762
Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: Usp52, 1200014O24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Fkbp8
Name: FK506 binding protein 8
Synonyms: 38kDa, Fkbp38
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14232
HGNC: HGNC:3724
Homologene: 7720
Kremen1
Name: kringle containing transmembrane protein 1
Synonyms: Krm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 84035
Homologene: 12935
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Cdan1
Name: codanin 1
Synonyms: CDA-I, 1500015A01Rik, codanin-1, CDA1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Canx
Name: calnexin
Synonyms: 1110069N15Rik, CNX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12330
HGNC: HGNC:1473
Homologene: 1324
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17089
Homologene: 41200
Stau2
Name: staufen double-stranded RNA binding protein 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29819
Homologene: 8666
Cpsf3
Name: cleavage and polyadenylation specificity factor 3
Synonyms: 73 kDa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54451
VEGA: 12
HGNC: HGNC:2326
Homologene: 6499
Dhx29
Name: DExH-box helicase 29
Synonyms: E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Me2
Name: malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms: D030040L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107029
VEGA: 18
HGNC: HGNC:6984
Homologene: 37615
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Grk1
Name: G protein-coupled receptor kinase 1
Synonyms: RK, Rhok
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24013
Homologene: 2197
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Schnurri-2, MIBP1, Gm20114, Shn-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, N-3 kinesin, Kns1, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Dennd5a
Name: DENN domain containing 5A
Synonyms: 1500012B19Rik, ORF37, Rab6ip1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19347
Homologene: 14584
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
Or5al1
Name: olfactory receptor family 5 subfamily AL member 1
Synonyms: GA_x6K02T2Q125-47629317-47628376, MOR185-10, Olfr1042
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257941
Homologene: 133665
Adam2
Name: a disintegrin and metallopeptidase domain 2
Synonyms: Ftnb, Ph30-beta, fertilin beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11495
VEGA: 14
HGNC: HGNC:198
Homologene: 1127
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: 9130201M22Rik, semF, M-Sema D, Semaf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
9330159F19Rik
Name: RIKEN cDNA 9330159F19 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212448
VEGA: 10
Homologene: 8804
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Vmn2r95
Name: vomeronasal 2, receptor 95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328759
Homologene: 115024
Or5d43
Name: olfactory receptor family 5 subfamily D member 43
Synonyms: Olfr1173, GA_x6K02T2Q125-49759783-49758845, MOR174-20_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404329
Homologene: 128091
Plod3
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms: lysyl hydroxylase 3, LH3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26433
HGNC: HGNC:9083
Homologene: 843
Tspan32
Name: tetraspanin 32
Synonyms: Art-1, Tspan32, Phemx, D7Wsu37e, Tssc6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27027
Homologene: 10650
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Plxnb3
Name: plexin B3
Synonyms: Plxn6
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 140571
HGNC: HGNC:9105
Homologene: 68468
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Acsm4
Name: acyl-CoA synthetase medium-chain family member 4
Synonyms: OMACS, O-MACS
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233801
Homologene: 72281
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Or51f1
Name: olfactory receptor family 51 subfamily F member 1
Synonyms: Olfr566, MOR14-7P, GA_x6K02T2PBJ9-5560696-5559746
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258168
Homologene: 133721
Mocs2
Name: molybdenum cofactor synthesis 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17434
HGNC: HGNC:7193
Homologene: 32193
Or14j6
Name: olfactory receptor family 14 subfamily J member 6
Synonyms: Olfr127, MOR218-7, GA_x6K02T2PSCP-2354126-2355093
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258374
Homologene: 134080
Tdrkh
Name: tudor and KH domain containing protein
Synonyms: 2700091C21Rik, Tdrd2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72634
Homologene: 4999
Mettl25b
Name: methyltransferase like 25B
Synonyms: BC023814, Rrnad1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229503
Homologene: 9332
Lmx1b
Name: LIM homeobox transcription factor 1 beta
Synonyms: GENA 191, Icst, LMX1.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16917
HGNC: HGNC:6654
Homologene: 55648
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 16,440,313 bp
  • T to A, chromosome 1 at 93,025,694 bp
  • A to G, chromosome 1 at 135,967,180 bp
  • C to A, chromosome 1 at 138,534,389 bp
  • A to G, chromosome 1 at 150,677,222 bp
  • T to C, chromosome 2 at 33,569,094 bp
  • A to G, chromosome 2 at 76,969,249 bp
  • A to G, chromosome 2 at 86,159,938 bp
  • A to G, chromosome 2 at 88,275,004 bp
  • A to G, chromosome 2 at 120,725,632 bp
  • G to A, chromosome 2 at 120,731,020 bp
  • T to C, chromosome 2 at 165,812,475 bp
  • C to A, chromosome 3 at 38,982,346 bp
  • T to A, chromosome 3 at 59,073,168 bp
  • T to C, chromosome 3 at 87,926,828 bp
  • A to G, chromosome 3 at 94,428,249 bp
  • A to G, chromosome 4 at 43,256,834 bp
  • A to C, chromosome 4 at 62,334,252 bp
  • T to C, chromosome 4 at 127,123,296 bp
  • C to A, chromosome 5 at 38,231,262 bp
  • A to T, chromosome 5 at 136,994,192 bp
  • A to G, chromosome 7 at 16,906,869 bp
  • A to G, chromosome 7 at 102,856,617 bp
  • C to T, chromosome 7 at 104,472,521 bp
  • G to A, chromosome 7 at 107,789,111 bp
  • A to G, chromosome 7 at 109,905,699 bp
  • G to T, chromosome 7 at 118,196,044 bp
  • A to T, chromosome 7 at 119,703,365 bp
  • T to A, chromosome 7 at 143,006,998 bp
  • T to A, chromosome 8 at 13,409,907 bp
  • A to G, chromosome 8 at 37,526,192 bp
  • T to G, chromosome 8 at 70,534,867 bp
  • C to T, chromosome 8 at 70,590,879 bp
  • C to T, chromosome 8 at 83,233,532 bp
  • G to A, chromosome 8 at 123,316,363 bp
  • T to C, chromosome 9 at 66,562,591 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • A to G, chromosome 10 at 29,224,809 bp
  • G to A, chromosome 10 at 97,612,845 bp
  • C to T, chromosome 10 at 128,315,177 bp
  • CGGG to CGGGGGG, chromosome 11 at 5,201,791 bp
  • A to G, chromosome 11 at 50,308,383 bp
  • A to G, chromosome 12 at 21,313,805 bp
  • T to C, chromosome 12 at 57,697,452 bp
  • T to C, chromosome 13 at 13,673,245 bp
  • C to T, chromosome 13 at 112,930,921 bp
  • T to A, chromosome 13 at 114,825,267 bp
  • G to A, chromosome 14 at 66,057,610 bp
  • T to C, chromosome 14 at 97,840,109 bp
  • T to C, chromosome 15 at 32,568,699 bp
  • T to A, chromosome 16 at 29,298,194 bp
  • T to A, chromosome 17 at 18,440,096 bp
  • A to T, chromosome 17 at 37,903,609 bp
  • A to G, chromosome 18 at 73,781,132 bp
  • T to C, chromosome X at 73,771,220 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3957 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040931-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.