Strain Name:
C57BL/6J-MtgxR5053Btlr/Mmmh
Stock Number:
042643-MU
Citation ID:
RRID:MMRRC_042643-MU
Other Names:
R5053 (G1), C57BL/6J-MtgxR5053Btlr
Major Collection:

Strain Information

Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228829
Homologene: 9507
Adsl
Name: adenylosuccinate lyase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11564
HGNC: HGNC:291
Homologene: 12
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 81898
Homologene: 6696
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226747
Homologene: 9142
Ubap1
Name: ubiquitin-associated protein 1
Synonyms: 2700092A01Rik, NAG20
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67123
Homologene: 9554
Ndc1
Name: NDC1 transmembrane nucleoporin
Synonyms: 2810475A17Rik, Tmem48, sks
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72787
Homologene: 41224
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Amhr2
Name: anti-Mullerian hormone type 2 receptor
Synonyms: MIS TypeII receptor, MISIIR
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110542
HGNC: HGNC:465
Homologene: 10746
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: 4932416N17Rik, curt
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74374
Homologene: 71019
Gna12
Name: guanine nucleotide binding protein, alpha 12
Synonyms: Galpha12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14673
HGNC: HGNC:4380
Homologene: 22398
Lmnb2
Name: lamin B2
Synonyms: lamin B3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16907
HGNC: HGNC:6638
Homologene: 7818
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Mme
Name: membrane metallo endopeptidase
Synonyms: CD10, neprilysin, 6030454K05Rik, NEP, neutral endopeptidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Psmd2
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
Synonyms: TEG-190, Tex190, 9430095H01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21762
HGNC: HGNC:9559
Homologene: 2101
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: 1810024J13Rik, Sec31l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Dennd6a
Name: DENN domain containing 6A
Synonyms: A630054L15Rik, Fam116a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211922
Homologene: 13503
Sp8
Name: trans-acting transcription factor 8
Synonyms: mBtd, D930049B17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320145
VEGA: 12
Homologene: 18548
Usf3
Name: upstream transcription factor family member 3
Synonyms: LOC207806, LOC385650, 5530400K22Rik, Gm608
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Prlr
Name: prolactin receptor
Synonyms: Pr-1, Prlr-rs1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19116
HGNC: HGNC:9446
Homologene: 733
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Oca2
Name: oculocutaneous albinism II
Synonyms: D7H15S12, D7H15S12, p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Vmn1r76
Name: vomeronasal 1 receptor 76
Synonyms: V1rg4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171239
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Mbd6
Name: methyl-CpG binding domain protein 6
Synonyms: D10Wsu93e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110962
Homologene: 14171
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Cyp2c37
Name: cytochrome P450, family 2. subfamily c, polypeptide 37
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13096
Homologene: 137231
Or4c15
Name: olfactory receptor family 4 subfamily C member 15
Synonyms: GA_x6K02T2Q125-50409367-50408432, MOR233-16P, MOR233-21, Olfr1211
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258025
Homologene: 81548
Acvrl1
Name: activin A receptor, type II-like 1
Synonyms: Alk1, activin receptor-like kinase-1, Acvrlk1, Alk-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11482
HGNC: HGNC:175
Homologene: 20058
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Zfp819
Name: zinc finger protein 819
Synonyms: 4930427I11Rik, 4933405K07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74400
Homologene: 128446
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Tmem150c
Name: transmembrane protein 150C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231503
Homologene: 18818
Psg18
Name: pregnancy specific beta-1-glycoprotein 18
Synonyms: mmCGM6, Cea-3, Cea3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26438
HGNC: HGNC:9524
Homologene: 110989
Or8k25
Name: olfactory receptor family 8 subfamily K member 25
Synonyms: GA_x6K02T2Q125-47883395-47882454, MOR188-1, MOR188-9, MOR188-1, MOR188-7, Olfr1515, Olfr1061
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259022
Homologene: 79468
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Klhl11
Name: kelch-like 11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217194
Homologene: 10030
Or10ab4
Name: olfactory receptor family 10 subfamily AB member 4
Synonyms: GA_x6K02T2PBJ9-10384085-10385068, MOR267-15, Olfr479
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257891
Homologene: 79346
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Etfbkmt
Name: electron transfer flavoprotein beta subunit lysine methyltransferase
Synonyms: 4833442J19Rik, Mettl20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320204
Homologene: 14453
Adgrf2
Name: adhesion G protein-coupled receptor F2
Synonyms: PGR20, Gpr111
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 435529
Homologene: 45213
Erg
Name: ETS transcription factor
Synonyms: D030036I24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13876
HGNC: HGNC:3446
Homologene: 15848
Or11h23
Name: olfactory receptor family 11 subfamily G member 23
Synonyms: GA_x6K02T2PMLR-6454789-6455712, MOR106-9P, Olfr748
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258113
Homologene: 134081
Ero1b
Name: endoplasmic reticulum oxidoreductase 1 beta
Synonyms: 1700065B09Rik, 1300013B24Rik, Ero1lb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67475
VEGA: 13
Homologene: 8740
Pla2g2e
Name: phospholipase A2, group IIE
Synonyms: mGIIEsPLA2s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26970
Homologene: 8083
Sh3d21
Name: SH3 domain containing 21
Synonyms: 1700029G01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66938
Homologene: 12057
Trim3
Name: tripartite motif-containing 3
Synonyms: BERP1, HAC1, Rnf22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55992
Homologene: 21290
Bcl11a
Name: BCL11 transcription factor A
Synonyms: mouse myeloid leukemia gene, COUP-TF interacting protein 1, CTIP1, Evi9, 2810047E18Rik, D930021L15Rik, Evi9c, Evi9b, Evi9a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Serpina3k
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3K
Synonyms: contrapsin, Spi-2, D12Rp54, RP54, Spi2, MMSpi2, MMCM2, alpha-1 antiproteinase, 1300001I07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20714
HGNC: HGNC:16
Homologene: 111129
Alg9
Name: ALG9 alpha-1,2-mannosyltransferase
Synonyms: 8230402H15Rik, B430313H07Rik, Dibd1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102580
Homologene: 6756
Sertad3
Name: SERTA domain containing 3
Synonyms: Rbt1, Sei3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 170742
Homologene: 8361
Or1ad1
Name: olfactory receptor family 1 subfamily AD member 1
Synonyms: GA_x6K02T2QP88-4453480-4452557, MOR129-1, Olfr1377
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258913
Homologene: 64929
Llcfc1
Name: LLLL and CFNLAS motif containing 1
Synonyms: 1700034O15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76606
Homologene: 81932
As3mt
Name: arsenite methyltransferase
Synonyms: Cyt19, 2310045H08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 57344
VEGA: 19
Homologene: 10754
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100417675
C130026L21Rik
Name: RIKEN cDNA C130026L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330164
A430057M04Rik
Name: RIKEN cDNA A430057M04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319486
Gm815
Name: predicted gene 815
Synonyms: LOC329047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329047
VEGA: 19
Gm28036
Name: predicted gene, 28036
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,735,089 bp
  • A to T, chromosome 1 at 54,997,177 bp
  • A to G, chromosome 1 at 82,286,922 bp
  • A to G, chromosome 1 at 179,786,784 bp
  • A to T, chromosome 2 at 4,603,921 bp
  • C to T, chromosome 2 at 59,820,263 bp
  • A to G, chromosome 2 at 86,413,338 bp
  • C to A, chromosome 2 at 88,930,253 bp
  • A to G, chromosome 2 at 155,962,928 bp
  • A to C, chromosome 2 at 156,126,398 bp
  • T to C, chromosome 2 at 156,273,862 bp
  • T to C, chromosome 2 at 181,649,453 bp
  • T to A, chromosome 3 at 63,364,849 bp
  • T to C, chromosome 3 at 144,911,121 bp
  • T to A, chromosome 3 at 157,541,159 bp
  • T to A, chromosome 4 at 41,387,315 bp
  • T to C, chromosome 4 at 107,374,218 bp
  • T to A, chromosome 4 at 126,152,397 bp
  • T to G, chromosome 4 at 138,880,375 bp
  • A to G, chromosome 4 at 152,544,462 bp
  • A to T, chromosome 5 at 57,721,601 bp
  • A to T, chromosome 5 at 100,083,740 bp
  • G to T, chromosome 5 at 100,393,214 bp
  • A to G, chromosome 5 at 111,581,763 bp
  • C to A, chromosome 5 at 140,760,727 bp
  • G to T, chromosome 6 at 29,496,958 bp
  • A to G, chromosome 6 at 41,685,335 bp
  • A to T, chromosome 6 at 89,322,460 bp
  • T to A, chromosome 6 at 149,147,268 bp
  • T to C, chromosome 7 at 11,930,314 bp
  • G to A, chromosome 7 at 14,580,975 bp
  • C to T, chromosome 7 at 18,345,934 bp
  • T to A, chromosome 7 at 27,476,522 bp
  • C to T, chromosome 7 at 43,617,146 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • C to A, chromosome 7 at 56,323,580 bp
  • G to T, chromosome 7 at 105,617,761 bp
  • A to G, chromosome 7 at 108,055,534 bp
  • G to T, chromosome 9 at 50,788,172 bp
  • A to T, chromosome 9 at 66,470,326 bp
  • A to T, chromosome 9 at 107,514,864 bp
  • A to G, chromosome 10 at 18,140,345 bp
  • A to T, chromosome 10 at 80,904,655 bp
  • T to A, chromosome 10 at 107,563,202 bp
  • C to T, chromosome 10 at 127,286,441 bp
  • C to A, chromosome 11 at 24,164,068 bp
  • G to A, chromosome 11 at 50,985,310 bp
  • C to T, chromosome 11 at 100,472,200 bp
  • T to A, chromosome 12 at 103,104,748 bp
  • T to C, chromosome 12 at 104,343,214 bp
  • C to T, chromosome 12 at 118,849,604 bp
  • T to C, chromosome 13 at 12,599,906 bp
  • T to C, chromosome 14 at 21,847,696 bp
  • C to A, chromosome 14 at 26,608,583 bp
  • T to A, chromosome 14 at 50,710,511 bp
  • C to A, chromosome 15 at 10,325,385 bp
  • T to C, chromosome 15 at 80,960,450 bp
  • A to T, chromosome 15 at 101,137,369 bp
  • G to A, chromosome 15 at 102,447,258 bp
  • T to C, chromosome 16 at 10,576,597 bp
  • T to A, chromosome 16 at 20,651,893 bp
  • T to C, chromosome 16 at 44,217,187 bp
  • T to A, chromosome 16 at 95,524,534 bp
  • A to G, chromosome 17 at 42,710,443 bp
  • C to T, chromosome 19 at 26,886,413 bp
  • G to A, chromosome 19 at 40,001,887 bp
  • A to G, chromosome 19 at 46,709,054 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5053 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042643-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.