Strain Name:
C57BL/6J-MtgxR6642Btlr/Mmmh
Stock Number:
044763-MU
Citation ID:
RRID:MMRRC_044763-MU
Other Names:
R6642 (G1)
Major Collection:

Strain Information

Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Kctd9
Name: potassium channel tetramerisation domain containing 9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105440
Homologene: 9754
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Gins1
Name: GINS complex subunit 1
Synonyms: 2810418N01Rik, Psf1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69270
Homologene: 44516
Aip
Name: aryl-hydrocarbon receptor-interacting protein
Synonyms: Fkbp16, Ara9, D19Bwg1412e, Xap2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11632
HGNC: HGNC:358
Homologene: 2959
Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms: 14-3-3 zeta, 1110013I11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22631
Homologene: 56528
Olfm4
Name: olfactomedin 4
Synonyms: LOC380924, GC1, GW112, LOC239192, OlfD, pPD4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380924
VEGA: 14
Homologene: 4684
Mbip
Name: MAP3K12 binding inhibitory protein 1
Synonyms: 4933408E06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217588
VEGA: 12
Homologene: 9576
Prdm4
Name: PR domain containing 4
Synonyms: 2810470D21Rik, 1700031E19Rik, SC1, SC-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Trim33
Name: tripartite motif-containing 33
Synonyms: ectodermin, Tif1g, Ecto, 8030451N04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: TRPC7, Trrp7, 9830168K16Rik, LTRPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28240
Homologene: 20709
Il16
Name: interleukin 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Aldh1a7, retinaldehyde dehydrogenase, Raldh2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19378
Homologene: 68368
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Fzd1
Name: frizzled class receptor 1
Synonyms: FZ-1, Fz1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14362
HGNC: HGNC:4038
Homologene: 20750
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Ablim1
Name: actin-binding LIM protein 1
Synonyms: abLIM-S, 9330196J19Rik, 2210411C18Rik, abLIM-L, abLIM-M, 4833406P10Rik, Limab1, 2610209L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Card4, Nlrc1, F830007N14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: CIP85, 1810012I01Rik, Rutbc3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105835
Homologene: 9249
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Xylb
Name: xylulokinase homolog (H. influenzae)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102448
VEGA: 9
Homologene: 3746
Vmn1r233
Name: vomeronasal 1 receptor 233
Synonyms: V1rf5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171236
Homologene: 128343
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228778
Homologene: 51916
Ctrl
Name: chymotrypsin-like
Synonyms: 1810004D15Rik, Ctra-1, 0910001G08Rik, Ctra1, chymopasin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109660
HGNC: HGNC:2524
Homologene: 37549
Gpr149
Name: G protein-coupled receptor 149
Synonyms: R35, 9630018L10Rik, Ieda, PGR10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
Rundc3b
Name: RUN domain containing 3B
Synonyms: LOC242819
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242819
Homologene: 16286
Or6c214
Name: olfactory receptor family 6 subfamily C member 214
Synonyms: MOR117-1, Olfr807, GA_x6K02T2PULF-11434134-11433199
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258931
Homologene: 27300
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Rassf10
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
Synonyms: 4632411J06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78748
Homologene: 121963
Tmc7
Name: transmembrane channel-like gene family 7
Synonyms: C630024K23Rik, 1700030H01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209760
Homologene: 36424
Cplx2
Name: complexin 2
Synonyms: 921-L, Gm34843
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12890
HGNC: HGNC:2310
Homologene: 38212
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 76,735,396 bp
  • T to C, chromosome 2 at 150,928,118 bp
  • T to A, chromosome 2 at 152,440,870 bp
  • C to T, chromosome 3 at 62,530,574 bp
  • T to C, chromosome 3 at 103,337,514 bp
  • A to G, chromosome 5 at 4,755,696 bp
  • A to T, chromosome 5 at 8,579,071 bp
  • T to G, chromosome 6 at 54,948,029 bp
  • A to G, chromosome 7 at 83,688,127 bp
  • A to G, chromosome 7 at 105,703,799 bp
  • A to T, chromosome 7 at 112,955,577 bp
  • A to T, chromosome 7 at 118,545,611 bp
  • C to T, chromosome 8 at 105,932,819 bp
  • A to T, chromosome 9 at 71,252,986 bp
  • A to G, chromosome 9 at 105,644,646 bp
  • A to G, chromosome 9 at 119,367,493 bp
  • C to T, chromosome 10 at 77,937,826 bp
  • T to C, chromosome 10 at 85,907,818 bp
  • A to T, chromosome 10 at 120,084,930 bp
  • A to T, chromosome 10 at 129,755,363 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • A to T, chromosome 12 at 56,342,406 bp
  • G to T, chromosome 13 at 54,378,923 bp
  • C to T, chromosome 13 at 68,620,826 bp
  • T to C, chromosome 14 at 51,990,962 bp
  • T to A, chromosome 14 at 67,724,673 bp
  • A to G, chromosome 14 at 80,021,667 bp
  • T to C, chromosome 15 at 36,790,922 bp
  • C to T, chromosome 15 at 81,009,700 bp
  • C to T, chromosome 16 at 14,132,747 bp
  • A to T, chromosome 17 at 20,583,517 bp
  • A to T, chromosome 17 at 20,993,740 bp
  • A to T, chromosome 17 at 28,961,666 bp
  • C to A, chromosome 19 at 4,115,149 bp
  • A to G, chromosome 19 at 57,130,852 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6642 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044763-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.