Strain Name:
C57BL/6J-MtgxR6989Btlr/Mmmh
Stock Number:
045095-MU
Citation ID:
RRID:MMRRC_045095-MU
Other Names:
R6989 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: VGLUT2, 2900073D12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140919
Homologene: 121617
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, 6030405M08Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Fkbp5
Name: FK506 binding protein 5
Synonyms: Dit1, D17Ertd592e, FKBP51
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Ect2
Name: ect2 oncogene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13605
HGNC: HGNC:3155
Homologene: 7298
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Gpi-1s, Gpi-1t, Gpi-1, autocrine motility factor, AMF, NK, Gpi1-t, maturation factor, Org, neuroleukin, NK/GPI, Gpi-1r, MF, Gpi1-s, Gpi1-r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Tbc1d15
Name: TBC1 domain family, member 15
Synonyms: 4432405K22Rik, Ly6dl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66687
VEGA: 10
Homologene: 11249
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Gpr1g, E130018M02Rik, mGluR7, mGlu7a receptor, 6330570A01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, repro4, Mtap2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Rpn1
Name: ribophorin I
Synonyms: Rpn-1, D6Wsu137e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 103963
Homologene: 2213
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329002
Homologene: 7198
Rtn3
Name: reticulon 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Ube2t
Name: ubiquitin-conjugating enzyme E2T
Synonyms: 2700084L22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67196
Homologene: 40929
Enpep
Name: glutamyl aminopeptidase
Synonyms: Ly51, aminopeptidase-A, 6030431M22Rik, APA, Bp-1/6C3, Ly-51
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Sec14l1
Name: SEC14-like lipid binding 1
Synonyms: 1200017E04Rik, 2810012L19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74136
Homologene: 37719
Zfp429
Name: zinc finger protein 429
Synonyms: 2810487A22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72807
Homologene: 110878
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Ufm1
Name: ubiquitin-fold modifier 1
Synonyms: 1810045K17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67890
Homologene: 9594
Fbp2
Name: fructose bisphosphatase 2
Synonyms: FBPase muscle, Fbp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14120
VEGA: 13
HGNC: HGNC:3607
Homologene: 55784
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Ggt7
Name: gamma-glutamyltransferase 7
Synonyms: 1110017C11Rik, Ggtl3, 6330563L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 207182
HGNC: HGNC:4259
Homologene: 70866
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Aox1
Name: aldehyde oxidase 1
Synonyms: Aox-1, retinal oxidase, Aox-2, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2A, Sur2, SUR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Vil1
Name: villin 1
Synonyms: Villin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22349
Homologene: 5169
Cpne9
Name: copine family member IX
Synonyms: A730016F12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211232
Homologene: 84686
Alk
Name: anaplastic lymphoma kinase
Synonyms: Tcrz, CD246
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Gpx5
Name: glutathione peroxidase 5
Synonyms: Arep
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14780
HGNC: HGNC:4557
Homologene: 1155
Arhgap26
Name: Rho GTPase activating protein 26
Synonyms: 4933432P15Rik, 2610010G17Rik, 1810044B20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71302
Homologene: 36349
Dtx3
Name: deltex 3, E3 ubiquitin ligase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 80904
Homologene: 12754
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
4921536K21Rik
Name: RIKEN cDNA 4921536K21 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67430
Homologene: 12129
Slc18a1
Name: solute carrier family 18 (vesicular monoamine), member 1
Synonyms: 4832416I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110877
Homologene: 20664
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Arl8a
Name: ADP-ribosylation factor-like 8A
Synonyms: Arl10b, 1110033P22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68724
Homologene: 23600
Amh
Name: anti-Mullerian hormone
Synonyms: MIS, Mullerian inhibiting substance
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11705
VEGA: 10
HGNC: HGNC:464
Homologene: 68060
Haao
Name: 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms: 0610012J07Rik, 3-HAOxase, 0610007K21Rik, 3-HAO, 3HAO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 107766
VEGA: 17
HGNC: HGNC:4796
Homologene: 8148
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Cpa5
Name: carboxypeptidase A5
Synonyms: 4930430M09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74649
Homologene: 62246
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: 3alpha-HSD, Hsd17b5, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Erich3
Name: glutamate rich 3
Synonyms: 5031409G23Rik, 4922501L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 209601
Homologene: 27877
Trpv6
Name: transient receptor potential cation channel, subfamily V, member 6
Synonyms: CAT, Ecac2, Cac, CaT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64177
Homologene: 56812
Fbxl21
Name: F-box and leucine-rich repeat protein 21
Synonyms: FBL3B, FBXL3B, Psttm, D630045D17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 213311
Homologene: 78724
Psmc2
Name: proteasome (prosome, macropain) 26S subunit, ATPase 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19181
HGNC: HGNC:9548
Homologene: 2096
Scgb1b10
Name: secretoglobin, family 1B, member 10
Synonyms: Abpa10, Gm4384
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102635992
Homologene: 114479
Trav3-3
Name: T cell receptor alpha variable 3-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 320898
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,068,815 bp
  • T to C, chromosome 1 at 58,085,452 bp
  • T to A, chromosome 1 at 66,414,906 bp
  • C to T, chromosome 1 at 74,423,954 bp
  • T to G, chromosome 1 at 134,969,295 bp
  • A to G, chromosome 1 at 135,146,997 bp
  • C to A, chromosome 2 at 69,472,455 bp
  • A to G, chromosome 2 at 82,976,954 bp
  • G to A, chromosome 2 at 90,707,020 bp
  • A to G, chromosome 2 at 155,503,460 bp
  • A to T, chromosome 3 at 27,102,488 bp
  • T to C, chromosome 3 at 53,857,981 bp
  • G to T, chromosome 3 at 129,280,950 bp
  • T to A, chromosome 3 at 135,235,127 bp
  • A to T, chromosome 3 at 154,763,677 bp
  • T to A, chromosome 5 at 21,801,219 bp
  • A to G, chromosome 5 at 50,006,884 bp
  • A to T, chromosome 5 at 136,279,648 bp
  • C to A, chromosome 6 at 17,535,928 bp
  • T to A, chromosome 6 at 17,535,929 bp
  • T to A, chromosome 6 at 30,625,892 bp
  • A to T, chromosome 6 at 41,625,456 bp
  • G to T, chromosome 6 at 88,099,303 bp
  • G to A, chromosome 6 at 111,207,805 bp
  • A to T, chromosome 6 at 113,300,583 bp
  • T to A, chromosome 6 at 142,688,981 bp
  • T to A, chromosome 7 at 3,822,164 bp
  • T to A, chromosome 7 at 27,280,840 bp
  • T to A, chromosome 7 at 32,101,149 bp
  • T to C, chromosome 7 at 34,202,520 bp
  • T to C, chromosome 7 at 51,661,476 bp
  • T to G, chromosome 7 at 141,639,979 bp
  • G to A, chromosome 8 at 69,038,862 bp
  • T to C, chromosome 8 at 88,308,786 bp
  • A to G, chromosome 9 at 119,486,329 bp
  • T to G, chromosome 10 at 41,581,353 bp
  • A to G, chromosome 10 at 80,805,504 bp
  • T to C, chromosome 10 at 88,778,240 bp
  • A to T, chromosome 10 at 115,209,569 bp
  • T to C, chromosome 10 at 127,192,877 bp
  • C to T, chromosome 11 at 3,890,076 bp
  • T to C, chromosome 11 at 58,287,402 bp
  • A to G, chromosome 11 at 117,156,394 bp
  • T to A, chromosome 13 at 4,449,046 bp
  • T to C, chromosome 13 at 21,287,499 bp
  • T to C, chromosome 13 at 56,527,061 bp
  • C to T, chromosome 13 at 62,858,177 bp
  • A to G, chromosome 13 at 67,389,961 bp
  • C to A, chromosome 14 at 53,666,345 bp
  • A to G, chromosome 14 at 54,468,493 bp
  • G to A, chromosome 14 at 121,627,379 bp
  • G to A, chromosome 14 at 122,650,288 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to A, chromosome 15 at 35,448,581 bp
  • G to A, chromosome 16 at 3,995,838 bp
  • C to T, chromosome 17 at 28,415,945 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • T to C, chromosome 17 at 67,753,758 bp
  • A to C, chromosome 17 at 71,897,952 bp
  • T to G, chromosome 17 at 74,630,989 bp
  • T to C, chromosome 17 at 83,831,674 bp
  • G to T, chromosome 18 at 39,099,629 bp
  • A to T, chromosome 18 at 82,628,363 bp
  • A to T, chromosome 19 at 4,921,167 bp
  • A to G, chromosome 19 at 7,456,491 bp
  • A to G, chromosome 19 at 43,832,172 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6989 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045095-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.