Strain Name:
C57BL/6J-MtgxR7328Btlr/Mmmh
Stock Number:
045421-MU
Citation ID:
RRID:MMRRC_045421-MU
Other Names:
R7328 (G1)
Major Collection:

Strain Information

Htr1d
Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: Htr1db, Gpcr14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15552
HGNC: HGNC:5289
Homologene: 20240
Taf15
Name: TATA-box binding protein associated factor 15
Synonyms: 68kDa, TAFII68, 2610111C21Rik, Taf2n
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70439
Homologene: 131088
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik, 2010203A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56484
Homologene: 31039
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 360013
Homologene: 7977
Trim66
Name: tripartite motif-containing 66
Synonyms: Tif1d, D7H11orf29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17279
Homologene: 32111
Arl4c
Name: ADP-ribosylation factor-like 4C
Synonyms: A630084M22Rik, Arl7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320982
HGNC: HGNC:698
Homologene: 4193
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Elf2
Name: E74-like factor 2
Synonyms: A230104O07Rik, 2610036A20Rik, NERF-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69257
HGNC: HGNC:3317
Homologene: 5006
Noc4l
Name: NOC4 like
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100608
Homologene: 40545
Slc39a6
Name: solute carrier family 39 (metal ion transporter), member 6
Synonyms: Zip6, Ermelin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106957
Homologene: 8199
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: mSiglec-F, Siglec5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Myof
Name: myoferlin
Synonyms: Fer1l3, E030042N20Rik, 2310051D19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Setd1b
Name: SET domain containing 1B
Synonyms: KMT2G
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208043
Homologene: 134654
Ephb2
Name: Eph receptor B2
Synonyms: eteck, Nuk, Cek5, Qek5, Prkm5, Sek3, Erk, Hek5, Drt, Tyro5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Rdh19
Name: retinol dehydrogenase 19
Synonyms: Rdhs, RDH-S
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216453
Homologene: 129514
Sybu
Name: syntabulin (syntaxin-interacting)
Synonyms: Golsyn/Syntabulin, A830027B17Rik, 5730410E15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319613
VEGA: 15
Homologene: 9838
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: 3110041O18Rik, ANG1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Ephb1
Name: Eph receptor B1
Synonyms: Net, Elkh, Elk, C130099E04Rik, Hek6, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, D12Bwg0831e, neurexin III alpha, 9330112C09Rik, neurexin III beta, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Hsdl1
Name: hydroxysteroid dehydrogenase like 1
Synonyms: 2700067E09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72552
Homologene: 100660
Cyp2j5
Name: cytochrome P450, family 2, subfamily j, polypeptide 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13109
HGNC: HGNC:2634
Homologene: 116530
4933427D14Rik
Name: RIKEN cDNA 4933427D14 gene
Synonyms: Gm43951
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74477
Homologene: 8874
Or8g23
Name: olfactory receptor family 8 subfamily G member 23
Synonyms: Olfr937, MOR171-24, GA_x6K02T2PVTD-32756567-32755632
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258431
VEGA: 9
HGNC: HGNC:8484
Homologene: 27167
Or5ae2
Name: olfactory receptor family 5 subfamily AE member 2
Synonyms: MOR254-2, Olfr291, GA_x6K02T2NHDJ-11231385-11230438
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258410
Homologene: 83130
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: C820004H04Rik, LL5b, LL5beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Atxn7l1
Name: ataxin 7-like 1
Synonyms: Atxn7l4, 2810423G08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380753
Homologene: 53366
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Or5j3
Name: olfactory receptor family 5 subfamily J member 3
Synonyms: MOR172-1, GA_x6K02T2Q125-47777498-47778436, Olfr1052
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259012
Homologene: 79679
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Vav3
Name: vav 3 oncogene
Synonyms: A530094I06Rik, Idd18.1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Tm4sf4
Name: transmembrane 4 superfamily member 4
Synonyms: il-TMP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229302
Homologene: 3393
Or5ak23
Name: olfactory receptor family 5 subfamily AK member 23
Synonyms: MOR203-2, Olfr993, GA_x6K02T2Q125-46891524-46890580
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258427
Homologene: 79352
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434440
Homologene: 110776
Ctdsp1
Name: CTD small phosphatase 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227292
Homologene: 100834
Herpud1
Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms: Mifl, Herp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64209
Homologene: 40973
Pcp4l1
Name: Purkinje cell protein 4-like 1
Synonyms: 1500036F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66425
Homologene: 136091
Rbfa
Name: ribosome binding factor A
Synonyms: 1110032A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68731
VEGA: 18
Homologene: 11725
Igkv8-34
Name: immunoglobulin kappa variable 8-34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620126
HGNC: HGNC:5834
Marchf9
Name: membrane associated ring-CH-type finger 9
Synonyms: March9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216438
Homologene: 34705
Igkv14-111
Name: immunoglobulin kappa variable 14-111
Synonyms: Gm16939
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545847
Inha
Name: inhibin alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16322
HGNC: HGNC:6065
Homologene: 1652
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 74,394,040 bp
  • T to C, chromosome 1 at 75,510,116 bp
  • C to A, chromosome 1 at 88,701,517 bp
  • A to T, chromosome 1 at 150,638,866 bp
  • A to T, chromosome 1 at 164,049,275 bp
  • G to A, chromosome 1 at 171,174,465 bp
  • T to C, chromosome 2 at 66,484,587 bp
  • A to G, chromosome 2 at 85,414,324 bp
  • GTACTTTTT to GT, chromosome 2 at 86,297,994 bp
  • T to C, chromosome 2 at 132,832,857 bp
  • A to G, chromosome 3 at 51,266,777 bp
  • A to T, chromosome 3 at 57,426,504 bp
  • A to T, chromosome 3 at 109,503,428 bp
  • A to T, chromosome 4 at 44,332,931 bp
  • A to G, chromosome 4 at 96,663,213 bp
  • G to A, chromosome 4 at 136,443,303 bp
  • C to T, chromosome 4 at 136,658,934 bp
  • C to T, chromosome 5 at 77,315,999 bp
  • C to A, chromosome 5 at 110,648,923 bp
  • T to A, chromosome 5 at 123,152,379 bp
  • T to C, chromosome 5 at 130,262,844 bp
  • T to A, chromosome 6 at 68,256,725 bp
  • A to G, chromosome 6 at 70,044,344 bp
  • T to A, chromosome 6 at 141,936,408 bp
  • C to T, chromosome 7 at 43,352,267 bp
  • T to C, chromosome 7 at 84,857,299 bp
  • C to A, chromosome 7 at 109,457,751 bp
  • T to C, chromosome 8 at 94,386,620 bp
  • T to C, chromosome 8 at 119,566,091 bp
  • T to C, chromosome 9 at 39,060,561 bp
  • A to G, chromosome 9 at 102,195,239 bp
  • C to A, chromosome 9 at 109,232,315 bp
  • A to T, chromosome 10 at 7,705,547 bp
  • A to T, chromosome 10 at 42,197,262 bp
  • T to C, chromosome 10 at 127,058,296 bp
  • T to C, chromosome 10 at 127,857,027 bp
  • T to A, chromosome 11 at 9,291,545 bp
  • C to G, chromosome 11 at 72,169,780 bp
  • T to C, chromosome 11 at 77,807,911 bp
  • C to T, chromosome 11 at 83,484,832 bp
  • T to C, chromosome 12 at 33,148,503 bp
  • T to C, chromosome 12 at 88,795,575 bp
  • T to C, chromosome 14 at 7,883,788 bp
  • T to A, chromosome 14 at 7,894,660 bp
  • G to A, chromosome 15 at 44,787,794 bp
  • T to A, chromosome 16 at 45,758,209 bp
  • G to A, chromosome 16 at 91,658,390 bp
  • T to A, chromosome 16 at 96,645,035 bp
  • T to C, chromosome 18 at 24,600,930 bp
  • C to A, chromosome 18 at 80,193,239 bp
  • C to T, chromosome 19 at 6,064,126 bp
  • T to C, chromosome 19 at 37,916,399 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7328 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045421-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.