Strain Name:
C57BL/6J-MtgxR7621Btlr/Mmmh
Stock Number:
045688-MU
Citation ID:
RRID:MMRRC_045688-MU
Other Names:
R7621 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Elf1
Name: E74 like ETS transcription factor 1
Synonyms: Elf-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13709
VEGA: 14
HGNC: HGNC:3316
Homologene: 7303
Lrrc2
Name: leucine rich repeat containing 2
Synonyms: 4933431K03Rik, 2400002D05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74249
Homologene: 23454
Csrnp1
Name: cysteine-serine-rich nuclear protein 1
Synonyms: taip-3, CSRNP-1, Axud1, 4931429D10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215418
VEGA: 9
Homologene: 13196
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), 9430023P16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Hars1
Name: histidyl-tRNA synthetase 1
Synonyms: Hars, MMHRS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15115
VEGA: 18
HGNC: HGNC:4816
Homologene: 1592
Pkm
Name: pyruvate kinase, muscle
Synonyms: Pkm2, Pk-3, Pk-2, Pk3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18746
VEGA: 9
HGNC: HGNC:9021
Homologene: 37650
Cpt1c
Name: carnitine palmitoyltransferase 1c
Synonyms: 9630004I06Rik, CPT I-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78070
Homologene: 17561
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, G1-403-16, 5330419I02Rik, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Synonyms: Nrf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18024
HGNC: HGNC:7782
Homologene: 2412
Wdr12
Name: WD repeat domain 12
Synonyms: 4933402C23Rik, Ytm1p, Ytm1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57750
Homologene: 10098
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: mbo, Phxr3, Sp6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: hsp110/105, HSP110, hsp-E7I, Hsp105
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15505
Homologene: 21322
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: 1110062G02Rik, Nobq1, Nob1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57915
Homologene: 56856
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik, sao
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68750
Homologene: 2218
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Glipr1l1
Name: GLI pathogenesis-related 1 like 1
Synonyms: 1700011E04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69286
VEGA: 10
Homologene: 83452
Kirrel1
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel, Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170643
Homologene: 10089
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68421
Homologene: 10156
Qtrt2
Name: queuine tRNA-ribosyltransferase accessory subunit 2
Synonyms: Qrtr2, Qtrtd1, 3110012M05Rik, 4930470H18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106248
Homologene: 41576
Lce1m
Name: late cornified envelope 1M
Synonyms: Lce5a, Sprrl10, 1110059L13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66203
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, Slc21a13, 4930422F19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Or55b3
Name: olfactory receptor family 55 subfamily B member 3
Synonyms: Olfr543, MOR42-2, GA_x6K02T2PBJ9-5199377-5198367
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257947
Homologene: 81631
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244234
Homologene: 133218
Krt6a
Name: keratin 6A
Synonyms: mK6[a], Krt2-6c, Krt2-6a, MK6a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16687
VEGA: 15
Homologene: 136794
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: Cytsb, 2810012G08Rik, B230396K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
Abca9
Name: ATP-binding cassette, sub-family A member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: Ankrd3, PKK, RIP4, DIk, ANKK2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Gsdma2
Name: gasdermin A2
Synonyms: 2210411P14Rik, Gsdml2, 2210009F20Rik, 2210006M16Rik, 2200001G21Rik, Gsdm2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76758
Spata17
Name: spermatogenesis associated 17
Synonyms: 1700065F16Rik, 4930504I07Rik, 4930513F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74717
Homologene: 12551
Vmn2r52
Name: vomeronasal 2, receptor 52
Synonyms: EG384534
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384534
Homologene: 129605
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: 9130201M22Rik, semF, M-Sema D, Semaf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Or14c45
Name: olfactory receptor family 14 subfamily C member 45
Synonyms: Olfr297, MOR220-3, GA_x6K02T2NHDJ-9587747-9586815
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258611
Homologene: 115526
Ces1g
Name: carboxylesterase 1G
Synonyms: Ses-1, Ces-1, Ces1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Or8c15
Name: olfactory receptor family 8 subfamily C member 15
Synonyms: Olfr893, GA_x6K02T2PVTD-31889215-31890153, MOR170-11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258333
Homologene: 133626
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Prr36
Name: proline rich 36
Synonyms: BC068157
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73072
Homologene: 136398
Pgap6
Name: post-glycosylphosphatidylinositol attachment to proteins 6
Synonyms: Tmem8, Rxylt1, M83
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 60455
Homologene: 10944
Sh2d5
Name: SH2 domain containing 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230863
Homologene: 20002
Saxo2
Name: stabilizer of axonemal microtubules 2
Synonyms: Fam154b, 1700129I04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330577
Homologene: 25135
Calm5
Name: calmodulin 5
Synonyms: Scarf2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 494124
Or4f14d
Name: olfactory receptor family 4 subfamily F member 14D
Synonyms: MOR245-1, MOR245-26, GA_x6K02T2Q125-73177039-73176101, Olfr1316
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258737
Homologene: 133651
Ighv11-2
Name: immunoglobulin heavy variable V11-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780818
Alyreffm10
Name: Aly/REF export factor family member 10
Synonyms: Gm4340
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100043292
Homologene: 130068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 24,728,544 bp
  • G to A, chromosome 1 at 60,097,589 bp
  • A to T, chromosome 1 at 152,841,544 bp
  • T to A, chromosome 1 at 187,122,636 bp
  • T to G, chromosome 2 at 62,250,479 bp
  • T to C, chromosome 2 at 75,679,413 bp
  • T to C, chromosome 2 at 112,130,581 bp
  • C to T, chromosome 3 at 87,088,221 bp
  • T to C, chromosome 3 at 93,017,870 bp
  • T to C, chromosome 3 at 122,961,285 bp
  • A to T, chromosome 4 at 3,789,834 bp
  • T to G, chromosome 4 at 138,256,839 bp
  • A to G, chromosome 5 at 64,264,330 bp
  • A to C, chromosome 5 at 149,632,075 bp
  • C to A, chromosome 6 at 113,144,049 bp
  • A to G, chromosome 6 at 142,161,017 bp
  • A to G, chromosome 7 at 10,173,347 bp
  • C to T, chromosome 7 at 44,967,092 bp
  • A to G, chromosome 7 at 45,793,417 bp
  • A to T, chromosome 7 at 82,648,417 bp
  • G to A, chromosome 7 at 86,527,072 bp
  • G to A, chromosome 7 at 102,477,265 bp
  • G to A, chromosome 7 at 140,296,829 bp
  • T to A, chromosome 8 at 4,213,150 bp
  • A to T, chromosome 8 at 93,328,466 bp
  • T to C, chromosome 9 at 38,209,151 bp
  • T to A, chromosome 9 at 59,678,158 bp
  • G to A, chromosome 9 at 110,980,831 bp
  • C to A, chromosome 9 at 119,977,092 bp
  • T to C, chromosome 10 at 104,195,959 bp
  • A to T, chromosome 10 at 112,060,395 bp
  • A to G, chromosome 11 at 62,128,384 bp
  • C to A, chromosome 11 at 86,707,486 bp
  • T to C, chromosome 11 at 98,649,549 bp
  • T to A, chromosome 11 at 110,160,533 bp
  • T to A, chromosome 12 at 114,048,388 bp
  • A to T, chromosome 13 at 3,854,629 bp
  • C to A, chromosome 13 at 37,949,066 bp
  • A to G, chromosome 14 at 79,570,882 bp
  • C to A, chromosome 15 at 32,609,232 bp
  • G to T, chromosome 15 at 101,691,752 bp
  • A to G, chromosome 16 at 43,868,940 bp
  • A to G, chromosome 16 at 96,064,887 bp
  • A to T, chromosome 16 at 97,745,925 bp
  • T to C, chromosome 17 at 14,674,164 bp
  • C to A, chromosome 17 at 26,117,891 bp
  • A to T, chromosome 18 at 36,770,423 bp
  • A to C, chromosome 19 at 23,994,804 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7621 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045688-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.