Strain Name:
C57BL/6J-MtgxR8006Btlr/Mmmh
Stock Number:
046046-MU
Citation ID:
RRID:MMRRC_046046-MU
Other Names:
R8006 (G1)
Major Collection:

Strain Information

Vcp
Name: valosin containing protein
Synonyms: p97, CDC48, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269523
Homologene: 5168
Jade1
Name: jade family PHD finger 1
Synonyms: Phf17, D530048A03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269424
Homologene: 18162
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D630045E04Rik, D730026A16Rik, MUF1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: Tiul1, 8030445B08Rik, AIP5, SDRP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Akap13
Name: A kinase anchor protein 13
Synonyms: 5730522G15Rik, 1700026G02Rik, PROTO-LB, Ht31, PROTO-LBC, 5830460E08Rik, AKAP-Lbc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Ppp1r10
Name: protein phosphatase 1, regulatory subunit 10
Synonyms: 2610025H06Rik, D17Ertd808e, PNUTS
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52040
HGNC: HGNC:9284
Homologene: 2033
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 4732460C16Rik, TAF2B, TAFII150, 150kDa, CIF150
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22775
Homologene: 32076
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: Fliiap1, FLAP (FLI LRR associated protein)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Slf2
Name: SMC5-SMC6 complex localization factor 2
Synonyms: Fam178a, 6030443O07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226151
VEGA: 19
Homologene: 23077
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234911
Homologene: 23345
Arl3
Name: ADP-ribosylation factor-like 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56350
VEGA: 19
HGNC: HGNC:694
Homologene: 48276
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Hisppd1, Vip2, Cfap160
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Mex3a
Name: mex3 RNA binding family member A
Synonyms: 2700083E18Rik, Rkhd4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72640
Homologene: 18950
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nob3, nerg1, mGluR6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Ccdc38
Name: coiled-coil domain containing 38
Synonyms: 4933417K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237465
Homologene: 52182
Or5ak24
Name: olfactory receptor family 5 subfamily AK member 24
Synonyms: Olfr994, MOR203-4, GA_x6K02T2Q125-46907515-46906571
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258425
Homologene: 17245
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Akip1
Name: A kinase interacting protein 1
Synonyms: ICRFP703N2430Q5.6, D7H11orf17, BCA3, ORF27, ICRFP703B1614Q5.6, D930014E17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57373
HGNC: HGNC:1170
Homologene: 10765
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: B230218L05Rik, LOC330998
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330998
Homologene: 19814
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Myot
Name: myotilin
Synonyms: Ttid, 5530402I04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58916
Homologene: 4942
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Synonyms: 11HSD2, 11(beta)-HSD2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15484
HGNC: HGNC:5209
Homologene: 20088
Khnyn
Name: KH and NYN domain containing
Synonyms: 9130227C08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219094
VEGA: 14
Homologene: 23611
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Ctnna3
Name: catenin alpha 3
Synonyms: Catna3, 4930429L08Rik, catenin (cadherin associated protein), alpha 3, alphaT-catenin, Vr22
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Cox18
Name: cytochrome c oxidase assembly protein 18
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231430
Homologene: 14821
Gm6871
Name: predicted gene 6871
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102642386
Spire1
Name: spire type actin nucleation factor 1
Synonyms: 6030430B19Rik, Spir-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
Mro
Name: maestro
Synonyms: 4933435E20Rik, 4930507C04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71263
Homologene: 41729
Tmem267
Name: transmembrane protein 267
Synonyms: Gm7120
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 633640
Homologene: 49708
Or10g6
Name: olfactory receptor family 10 subfamily G member 6
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8, Olfr981
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258283
VEGA: 9
Homologene: 64849
Nppa
Name: natriuretic peptide type A
Synonyms: ANP, natriuretic peptide precursor A, Anf, atrial natriuretic peptide, Pnd
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230899
HGNC: HGNC:7939
Homologene: 4498
Or52a20
Name: olfactory receptor family 52 subfamily A member 20
Synonyms: Olfr627, GA_x6K02T2PBJ9-6440320-6440766, MOR22-4, GA_x6K02T2L9TJ-1933-2295, Olfr243
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436002
Homologene: 8420
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 32,546,924 bp
  • A to G, chromosome 1 at 91,076,951 bp
  • A to G, chromosome 1 at 97,734,106 bp
  • A to G, chromosome 1 at 139,736,852 bp
  • T to C, chromosome 2 at 85,429,974 bp
  • A to G, chromosome 2 at 181,995,876 bp
  • A to T, chromosome 3 at 41,613,689 bp
  • T to A, chromosome 3 at 88,537,086 bp
  • A to T, chromosome 4 at 19,650,174 bp
  • A to T, chromosome 4 at 42,985,993 bp
  • G to A, chromosome 4 at 116,094,888 bp
  • T to A, chromosome 4 at 148,001,181 bp
  • A to T, chromosome 5 at 21,899,084 bp
  • C to T, chromosome 5 at 90,223,813 bp
  • A to T, chromosome 5 at 109,220,458 bp
  • A to C, chromosome 5 at 114,804,423 bp
  • C to T, chromosome 5 at 130,268,072 bp
  • A to T, chromosome 7 at 10,490,173 bp
  • T to C, chromosome 7 at 41,545,682 bp
  • T to A, chromosome 7 at 51,593,770 bp
  • T to C, chromosome 7 at 75,579,696 bp
  • T to A, chromosome 7 at 103,717,325 bp
  • A to G, chromosome 7 at 109,703,992 bp
  • T to A, chromosome 7 at 130,467,388 bp
  • T to A, chromosome 8 at 40,795,907 bp
  • T to A, chromosome 8 at 105,519,103 bp
  • C to T, chromosome 9 at 7,578,984 bp
  • T to G, chromosome 9 at 40,022,474 bp
  • T to A, chromosome 9 at 66,445,560 bp
  • T to A, chromosome 9 at 82,890,126 bp
  • T to C, chromosome 9 at 89,729,836 bp
  • C to T, chromosome 9 at 108,829,107 bp
  • A to G, chromosome 10 at 63,582,011 bp
  • A to T, chromosome 10 at 93,555,586 bp
  • A to G, chromosome 10 at 127,589,619 bp
  • A to T, chromosome 11 at 50,864,657 bp
  • A to G, chromosome 11 at 101,268,356 bp
  • T to C, chromosome 11 at 104,665,496 bp
  • C to T, chromosome 11 at 119,156,072 bp
  • T to A, chromosome 13 at 119,609,238 bp
  • G to A, chromosome 14 at 55,887,590 bp
  • A to G, chromosome 15 at 55,048,701 bp
  • T to C, chromosome 15 at 71,462,334 bp
  • A to G, chromosome 15 at 79,634,098 bp
  • A to T, chromosome 17 at 35,928,266 bp
  • A to G, chromosome 18 at 36,648,719 bp
  • T to A, chromosome 18 at 44,354,837 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • G to A, chromosome 18 at 67,501,181 bp
  • A to T, chromosome 18 at 73,877,506 bp
  • T to C, chromosome 19 at 9,012,083 bp
  • T to A, chromosome 19 at 44,942,317 bp
  • A to C, chromosome 19 at 46,558,374 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8006 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046046-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.