Strain Name:
C57BL/6J-MtgxR8104Btlr/Mmmh
Stock Number:
067535-MU
Citation ID:
RRID:MMRRC_067535-MU
Other Names:
R8104 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: Vdp, transcytosis associated protein p115, TAP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: subtilisin/kexin isozyme-1, S1P, site-1 protease, SKI-1, 0610038M03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56453
Homologene: 2808
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170753
Homologene: 64370
Wdr43
Name: WD repeat domain 43
Synonyms: 2610318G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72515
VEGA: 17
Homologene: 38810
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Rnps1
Name: RNA binding protein with serine rich domain 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19826
VEGA: 17
Homologene: 40648
Ascc1
Name: activating signal cointegrator 1 complex subunit 1
Synonyms: ASC1p50, 1810015P09Rik, CGI-18
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69090
VEGA: 10
Homologene: 41079
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: c-Cbl, 4732447J05Rik, Cbl-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Arfgap1
Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARF1 GAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228998
Homologene: 5517
Apoc3
Name: apolipoprotein C-III
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11814
HGNC: HGNC:610
Homologene: 136634
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Acsbg2
Name: acyl-CoA synthetase bubblegum family member 2
Synonyms: Bgr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328845
Homologene: 57133
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213783
Homologene: 18897
Ing5
Name: inhibitor of growth family, member 5
Synonyms: 1810018M11Rik, 1700027H23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66262
Homologene: 90955
Slc44a3
Name: solute carrier family 44, member 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213603
Homologene: 64830
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: NHE2, 4932415O19Rik, 2210416H12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226999
Homologene: 20661
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: LigI, mLigI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, 4732483H20Rik, 9630020C08Rik, steerin 3, unc53H3, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Got1l1
Name: glutamic-oxaloacetic transaminase 1-like 1
Synonyms: 1700083M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76615
Homologene: 65045
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 668758
Homologene: 110776
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Izumo3
Name: IZUMO family member 3
Synonyms: 1700011H22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69314
Homologene: 122080
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Slc45a3
Name: solute carrier family 45, member 3
Synonyms: 2210413P12Rik, IPCA-6, Pcanap6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212980
HGNC: HGNC:8642
Homologene: 23813
Tgtp1
Name: T cell specific GTPase 1
Synonyms: Mg21, Gtp2, Tgtp, Irgb6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21822
Homologene: 129991
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: CASP11, SIP1, Srsf2ip, 2610510E10Rik, 1110061H03Rik, Sfrs2ip, SRRP129
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Or2ag17
Name: olfactory receptor family 2 subfamily AG member 17
Synonyms: MOR283-10P, GA_x6K02T2PBJ9-9168355-9167405, Olfr699
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258180
Homologene: 79391
Or1i2
Name: olfactory receptor family 1 subfamily I member 1
Synonyms: MOR128-3, Olfr1357, GA_x6K02T2QGN0-3196801-3197742, MOR128-4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257883
HGNC: HGNC:8207
Homologene: 72920
Pde6a
Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms: Pdea
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225600
HGNC: HGNC:8785
Homologene: 380
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71062
Homologene: 12896
Dlgap3
Name: DLG associated protein 3
Synonyms: DAP3, PSD-95/SAP90-binding protein 3, Sapap3, Prpl8, SAP90/PSD 95 associated protein 3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242667
Homologene: 18276
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Or6c66b
Name: olfactory receptor family 6 subfamily C member 66B
Synonyms: MOR108-2, Olfr792, GA_x6K02T2PULF-11219415-11220350
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258150
Homologene: 133881
Gm4871
Name: predicted gene 4871
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231885
Homologene: 86127
Ccdc112
Name: coiled-coil domain containing 112
Synonyms: 8430438M01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240261
VEGA: 18
Homologene: 17617
Tubg1
Name: tubulin, gamma 1
Synonyms: 1500010O08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103733
Homologene: 833
Atat1
Name: alpha tubulin acetyltransferase 1
Synonyms: MEC-17, 0610011P08Rik, 3110080J08Rik, 2610008K08Rik, 2610110G12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73242
Homologene: 15129
Or14a257
Name: olfactory receptor family 14 subfamily A member 257
Synonyms: GA_x6K02T2NHDJ-9619796-9620794, MOR219-4, Olfr298
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257905
Serpina3a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3A
Synonyms: 4933406L18Rik, alpha-1 antiproteinase,, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74069
HGNC: HGNC:16
Ech1
Name: enoyl coenzyme A hydratase 1, peroxisomal
Synonyms: dienoyl-CoA isomerase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 51798
HGNC: HGNC:3149
Homologene: 1069
Asl
Name: argininosuccinate lyase
Synonyms: 2510006M18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109900
HGNC: HGNC:746
Homologene: 32
Pcdha4
Name: protocadherin alpha 4
Synonyms: Crnr1, Cnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12936
HGNC: HGNC:8670
Homologene: 130626
Slc25a1
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
Synonyms: 2610100G11Rik, Slc20a3, 1300019P08Rik, Dgsj
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13358
Homologene: 4362
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,718,649 bp
  • T to A, chromosome 1 at 74,626,597 bp
  • T to A, chromosome 1 at 93,816,444 bp
  • T to C, chromosome 1 at 131,977,016 bp
  • A to G, chromosome 1 at 195,117,617 bp
  • C to T, chromosome 2 at 76,880,223 bp
  • T to A, chromosome 2 at 180,979,229 bp
  • T to C, chromosome 3 at 9,565,241 bp
  • A to C, chromosome 3 at 121,497,872 bp
  • A to T, chromosome 4 at 92,146,908 bp
  • A to G, chromosome 4 at 127,236,154 bp
  • A to T, chromosome 5 at 41,833,732 bp
  • T to A, chromosome 5 at 92,158,421 bp
  • C to T, chromosome 5 at 130,011,950 bp
  • G to C, chromosome 5 at 145,032,202 bp
  • T to C, chromosome 7 at 13,286,565 bp
  • G to A, chromosome 7 at 28,825,303 bp
  • A to G, chromosome 7 at 78,577,702 bp
  • A to G, chromosome 7 at 86,489,023 bp
  • C to A, chromosome 7 at 106,791,130 bp
  • T to A, chromosome 7 at 106,791,131 bp
  • A to G, chromosome 7 at 141,804,783 bp
  • A to G, chromosome 8 at 27,197,591 bp
  • A to T, chromosome 8 at 88,665,057 bp
  • A to G, chromosome 8 at 119,529,055 bp
  • C to A, chromosome 9 at 44,158,539 bp
  • T to G, chromosome 9 at 46,233,287 bp
  • A to T, chromosome 9 at 109,326,289 bp
  • T to A, chromosome 10 at 3,952,326 bp
  • T to C, chromosome 10 at 60,007,729 bp
  • C to T, chromosome 10 at 78,612,408 bp
  • C to T, chromosome 10 at 88,757,904 bp
  • T to C, chromosome 10 at 92,691,916 bp
  • T to C, chromosome 10 at 109,758,967 bp
  • T to A, chromosome 10 at 129,540,957 bp
  • A to T, chromosome 11 at 48,987,014 bp
  • A to G, chromosome 11 at 63,078,119 bp
  • G to T, chromosome 11 at 101,124,028 bp
  • T to A, chromosome 12 at 81,983,611 bp
  • A to T, chromosome 12 at 104,112,851 bp
  • A to T, chromosome 13 at 38,168,624 bp
  • A to T, chromosome 13 at 81,440,225 bp
  • G to T, chromosome 13 at 103,834,977 bp
  • T to A, chromosome 13 at 113,319,729 bp
  • A to T, chromosome 14 at 50,959,642 bp
  • T to C, chromosome 15 at 96,418,602 bp
  • C to A, chromosome 15 at 102,239,899 bp
  • A to G, chromosome 16 at 17,926,433 bp
  • T to A, chromosome 17 at 24,424,510 bp
  • A to T, chromosome 17 at 35,904,116 bp
  • C to A, chromosome 17 at 56,845,443 bp
  • C to T, chromosome 17 at 71,616,355 bp
  • G to T, chromosome 18 at 36,954,053 bp
  • A to C, chromosome 18 at 46,287,653 bp
  • T to A, chromosome 18 at 61,231,494 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8104 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067535-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.