Strain Name:
C57BL/6J-MtgxR8288Btlr/Mmmh
Stock Number:
067710-MU
Citation ID:
RRID:MMRRC_067710-MU
Other Names:
R8288 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: c-KIT, belly-spot, CD117, SCO5, Tr-kit, SOW3, Steel Factor Receptor, Gsfsco1, Gsfsow3, Dominant white spotting, Gsfsco5, SCO1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: Rap, 4932417H02Rik, raptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74370
Homologene: 80210
Baiap2
Name: brain-specific angiogenesis inhibitor 1-associated protein 2
Synonyms: IRSp53
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108100
HGNC: HGNC:947
Homologene: 9697
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: NLRR-1, 2810047E21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16979
Homologene: 32036
Arpp19
Name: cAMP-regulated phosphoprotein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59046
Homologene: 21318
Stk24
Name: serine/threonine kinase 24
Synonyms: 1810013H02Rik, STE20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223255
VEGA: 14
Homologene: 20793
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: GMAP-210, 2610511G22Rik, 6030460N08Rik, TRIP230, 3110031G15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: damage-specific DNA-binding protein, DNA repair, p127-Ddb1, DNA repair protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Gstz1
Name: glutathione transferase zeta 1 (maleylacetoacetate isomerase)
Synonyms: maleylacetoacetate isomerase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14874
VEGA: 12
HGNC: HGNC:4643
Homologene: 7747
Mastl
Name: microtubule associated serine/threonine kinase-like
Synonyms: 2700091H24Rik, THC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67121
Homologene: 12086
Zfp738
Name: zinc finger protein 738
Synonyms: 3830402I07Rik, 6720487G11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408068
Homologene: 133713
Pah
Name: phenylalanine hydroxylase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18478
HGNC: HGNC:8582
Homologene: 234
Hsd17b13
Name: hydroxysteroid (17-beta) dehydrogenase 13
Synonyms: Pan1b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243168
Homologene: 71549
Cnnm3
Name: cyclin M3
Synonyms: Acdp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94218
HGNC: HGNC:104
Homologene: 23029
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: F630004O05Rik, D030022P06Rik, B930091H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Mtrp1, Trp1, Trrp1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22063
Homologene: 2478
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: Pla2epsilon, 2310026J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329502
Homologene: 65339
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, 1700034M11Rik, hy3, hyrh, hy-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2, Nav2.3, 1110034K09Rik, NaG, Scn6a, Nax
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232156
Homologene: 31125
Cpb1
Name: carboxypeptidase B1
Synonyms: 2210008M23Rik, 0910001A18Rik, 1810063F02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Trim40
Name: tripartite motif-containing 40
Synonyms: LOC240093, LOC195359, LOC333872
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 195359
Homologene: 34709
Kctd11
Name: potassium channel tetramerisation domain containing 11
Synonyms: Ren
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216858
Homologene: 17697
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 236573
Homologene: 128731
Eef2k
Name: eukaryotic elongation factor-2 kinase
Synonyms: eEF-2K
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13631
Homologene: 7299
Zfp446
Name: zinc finger protein 446
Synonyms: A630035I11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269870
Homologene: 9910
Nuak2
Name: NUAK family, SNF1-like kinase, 2
Synonyms: Snark, 1200013B22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74137
Homologene: 12539
Ap3m2
Name: adaptor-related protein complex 3, mu 2 subunit
Synonyms: 5830445E16Rik, AP-3B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64933
HGNC: HGNC:570
Homologene: 4950
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100504232
Homologene: 134535
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
Gm17079
Name: predicted gene 17079
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102640847
Homologene: 128452
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 36,511,993 bp
  • A to G, chromosome 1 at 66,473,350 bp
  • A to G, chromosome 1 at 68,298,350 bp
  • G to A, chromosome 1 at 82,287,961 bp
  • G to T, chromosome 1 at 132,327,841 bp
  • A to G, chromosome 1 at 173,274,789 bp
  • T to C, chromosome 2 at 23,133,359 bp
  • T to A, chromosome 2 at 66,675,974 bp
  • T to C, chromosome 2 at 118,790,281 bp
  • C to T, chromosome 2 at 120,188,509 bp
  • A to T, chromosome 3 at 20,265,367 bp
  • T to C, chromosome 4 at 118,389,776 bp
  • C to A, chromosome 5 at 14,712,871 bp
  • T to C, chromosome 5 at 75,654,489 bp
  • T to C, chromosome 5 at 87,001,457 bp
  • T to G, chromosome 5 at 103,963,835 bp
  • C to T, chromosome 5 at 105,105,733 bp
  • T to C, chromosome 6 at 83,226,255 bp
  • C to T, chromosome 6 at 107,566,994 bp
  • A to G, chromosome 7 at 12,977,958 bp
  • T to A, chromosome 7 at 120,903,381 bp
  • T to A, chromosome 7 at 127,531,356 bp
  • C to T, chromosome 8 at 22,793,137 bp
  • A to G, chromosome 8 at 110,507,029 bp
  • T to C, chromosome 9 at 75,037,632 bp
  • T to C, chromosome 9 at 95,721,381 bp
  • G to A, chromosome 10 at 87,538,185 bp
  • C to T, chromosome 11 at 69,880,057 bp
  • G to A, chromosome 11 at 119,857,937 bp
  • T to A, chromosome 11 at 119,997,639 bp
  • A to G, chromosome 12 at 87,147,830 bp
  • T to C, chromosome 12 at 101,894,384 bp
  • A to G, chromosome 12 at 116,213,725 bp
  • T to A, chromosome 13 at 67,670,789 bp
  • T to C, chromosome 13 at 93,708,824 bp
  • T to C, chromosome 14 at 51,694,358 bp
  • A to C, chromosome 14 at 121,293,429 bp
  • A to G, chromosome 15 at 23,445,987 bp
  • A to G, chromosome 16 at 37,027,910 bp
  • C to T, chromosome 16 at 57,570,554 bp
  • T to C, chromosome 17 at 36,883,318 bp
  • T to C, chromosome 19 at 10,608,348 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8288 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067710-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.