Strain Name:
C57BL/6J-MtgxR8406Btlr/Mmmh
Stock Number:
067765-MU
Citation ID:
RRID:MMRRC_067765-MU
Other Names:
R8406 (G1)
Major Collection:

Strain Information

Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Fis1
Name: fission, mitochondrial 1
Synonyms: Ttc11, 2010003O14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66437
Homologene: 41099
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, 1200014D21Rik, NBMPR-sensitive equilibrative nucleoside transporter
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1700086G08Rik, 1810060J02Rik, p56
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67015
Homologene: 10131
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67724
Homologene: 41000
Ythdf2
Name: YTH N6-methyladenosine RNA binding protein 2
Synonyms: 9430020E02Rik, NY-REN-2, HGRG8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213541
Homologene: 32302
Sh3glb1
Name: SH3-domain GRB2-like B1 (endophilin)
Synonyms: Endophilin B1, Bif-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54673
Homologene: 9337
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Dlx6
Name: distal-less homeobox 6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13396
HGNC: HGNC:2919
Homologene: 87855
Csf2rb2
Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms: BetaIl3, Il3r, Il3rb2, Bil3, AIC2A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12984
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Nectin2
Name: nectin cell adhesion molecule 2
Synonyms: Pvs, Pvrl2, MPH, nectin-2, Cd112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19294
HGNC: HGNC:9707
Homologene: 86092
Foxk1
Name: forkhead box K1
Synonyms: Mnf, A630048H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17425
Homologene: 82414
Arl3
Name: ADP-ribosylation factor-like 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56350
VEGA: 19
HGNC: HGNC:694
Homologene: 48276
Egln1
Name: egl-9 family hypoxia-inducible factor 1
Synonyms: ORF13, Phd2, SM-20, Hif-p4h-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 112405
HGNC: HGNC:1232
Homologene: 56936
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Ghrh
Name: growth hormone releasing hormone
Synonyms: Ghrf
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14601
HGNC: HGNC:4265
Homologene: 7731
Gdf5
Name: growth differentiation factor 5
Synonyms: cartilage-derived morphogenetic protein-1, CDMP-1, brp, bp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14563
HGNC: HGNC:4220
Homologene: 468
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70892
Homologene: 41578
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: Ccp4, EG244071, Nna1-l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244071
Homologene: 17552
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70882
Homologene: 31589
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13089
HGNC: HGNC:2615
Homologene: 74933
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 442827
Homologene: 53300
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, alcadein-beta, CSTN3, Clstn3b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232370
Homologene: 22836
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Zfp775
Name: zinc finger protein 775
Synonyms: C130032F08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243372
Homologene: 37089
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 9030605H24Rik, 5930426O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319767
Homologene: 70969
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 245860
Homologene: 34495
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Abca8a
Name: ATP-binding cassette, sub-family A member 8a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Zpr1
Name: ZPR1 zinc finger
Synonyms: Zfp259, ZPR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22687
Homologene: 2900
Pcdh18
Name: protocadherin 18
Synonyms: PCDH68L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73173
Homologene: 10389
Tnfrsf8
Name: tumor necrosis factor receptor superfamily, member 8
Synonyms: CD30
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21941
Homologene: 949
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Vma21-ps
Name: VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100040883
VEGA: 4
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: Gpr126, LOC215798, 1190004A11Rik, DREG
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215798
Homologene: 10724
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glurbeta2, Glur-6, C130030K03Rik, Glur6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: Sh3md4, 4831416G18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330502
Homologene: 51177
Pou2f3
Name: POU domain, class 2, transcription factor 3
Synonyms: Skin, Skn-li, Epoc-1, Otf-11, Skin-1a, Otf11, Oct11, Oct-11a, Skn-1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18988
Homologene: 7898
Vps37c
Name: vacuolar protein sorting 37C
Synonyms: 5730409F24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107305
VEGA: 19
Homologene: 45637
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: TULA-2, Sts-1, 2810457I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
Cabyr
Name: calcium binding tyrosine phosphorylation regulated
Synonyms: 1700016C01Rik, CBP86, FSP-2, 4933421A18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71132
Homologene: 49299
Or13a24
Name: olfactory receptor family 13 subfamily A member 24
Synonyms: Olfr1523-ps1, MOR253-10P, MOR253-13P, Olfr1553-ps1, MOR253-12P, Olfr538, GA_x6K02T2PBJ9-42723314-42724246, MOR253-12P, MOR253-13P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258201
Homologene: 110491
Trim35
Name: tripartite motif-containing 35
Synonyms: Hls5, A430106H13Rik, 0710005M05Rik, Mair
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66854
Homologene: 134331
Sirt6
Name: sirtuin 6
Synonyms: 2810449N18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50721
Homologene: 6924
Smtnl1
Name: smoothelin-like 1
Synonyms: 1110030K22Rik, Chasm
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68678
Homologene: 11488
Gnb2
Name: guanine nucleotide binding protein (G protein), beta 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14693
HGNC: HGNC:4398
Homologene: 68451
Aipl1
Name: aryl hydrocarbon receptor-interacting protein-like 1
Synonyms: A930007I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 114230
HGNC: HGNC:359
Homologene: 22806
Saraf
Name: store-operated calcium entry-associated regulatory factor
Synonyms: Tmem66, 1810045K07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67887
Homologene: 9398
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: neuferricin, 9330151E16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
Alkal2
Name: ALK and LTK ligand 2
Synonyms: Fam150b, 6230419C23Rik, Augalpha, Augmentor alpha
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100294583
VEGA: 12
Homologene: 87330
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 75,190,384 bp
  • G to A, chromosome 1 at 82,523,890 bp
  • A to T, chromosome 1 at 155,922,418 bp
  • A to T, chromosome 2 at 19,235,554 bp
  • C to T, chromosome 2 at 84,818,398 bp
  • T to A, chromosome 2 at 122,093,442 bp
  • C to A, chromosome 2 at 155,942,352 bp
  • T to A, chromosome 2 at 157,333,736 bp
  • T to G, chromosome 3 at 49,756,549 bp
  • G to T, chromosome 3 at 85,672,720 bp
  • T to C, chromosome 3 at 97,699,112 bp
  • T to G, chromosome 3 at 144,691,437 bp
  • T to C, chromosome 3 at 146,940,024 bp
  • C to T, chromosome 4 at 52,497,034 bp
  • T to C, chromosome 4 at 109,064,573 bp
  • A to G, chromosome 4 at 132,204,635 bp
  • A to G, chromosome 4 at 145,292,695 bp
  • A to T, chromosome 5 at 21,523,654 bp
  • A to T, chromosome 5 at 65,646,338 bp
  • A to G, chromosome 5 at 136,963,011 bp
  • A to G, chromosome 5 at 137,528,603 bp
  • G to T, chromosome 5 at 142,401,773 bp
  • A to T, chromosome 5 at 144,200,840 bp
  • A to T, chromosome 5 at 150,982,764 bp
  • T to G, chromosome 6 at 6,863,779 bp
  • T to C, chromosome 6 at 48,620,703 bp
  • T to A, chromosome 6 at 89,870,432 bp
  • A to T, chromosome 6 at 124,462,177 bp
  • T to C, chromosome 6 at 147,537,422 bp
  • A to T, chromosome 7 at 19,738,350 bp
  • T to C, chromosome 7 at 26,081,798 bp
  • A to G, chromosome 7 at 30,062,227 bp
  • A to G, chromosome 7 at 76,418,667 bp
  • A to T, chromosome 7 at 140,574,131 bp
  • C to T, chromosome 8 at 34,165,448 bp
  • G to T, chromosome 8 at 85,096,278 bp
  • A to T, chromosome 8 at 110,609,911 bp
  • A to G, chromosome 8 at 124,911,750 bp
  • C to T, chromosome 9 at 41,029,675 bp
  • T to C, chromosome 9 at 43,139,858 bp
  • T to A, chromosome 9 at 46,274,102 bp
  • T to C, chromosome 9 at 75,275,541 bp
  • A to T, chromosome 10 at 14,467,338 bp
  • A to T, chromosome 10 at 49,272,767 bp
  • G to C, chromosome 10 at 52,101,845 bp
  • T to C, chromosome 10 at 59,083,585 bp
  • A to T, chromosome 10 at 81,622,494 bp
  • T to G, chromosome 11 at 43,203,157 bp
  • T to A, chromosome 11 at 72,031,506 bp
  • T to C, chromosome 11 at 72,789,133 bp
  • A to G, chromosome 11 at 110,086,517 bp
  • G to T, chromosome 12 at 30,884,851 bp
  • C to T, chromosome 13 at 100,300,276 bp
  • C to T, chromosome 14 at 66,297,275 bp
  • T to G, chromosome 14 at 75,051,985 bp
  • T to C, chromosome 15 at 34,529,170 bp
  • T to C, chromosome 15 at 78,287,016 bp
  • A to C, chromosome 17 at 3,507,790 bp
  • C to T, chromosome 17 at 29,140,320 bp
  • A to T, chromosome 17 at 29,209,481 bp
  • C to A, chromosome 17 at 33,067,064 bp
  • T to A, chromosome 17 at 45,589,780 bp
  • C to A, chromosome 18 at 12,750,747 bp
  • A to T, chromosome 18 at 31,959,813 bp
  • T to A, chromosome 19 at 10,710,355 bp
  • A to T, chromosome 19 at 46,542,384 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067765-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.