Strain Name:
C57BL/6J-MtgxR8672Btlr/Mmmh
Stock Number:
068527-MU
Citation ID:
RRID:MMRRC_068527-MU
Other Names:
R8672 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: NPR-C, Nppc receptor, B430320C24Rik, lgj, longjohn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, LOC382930, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Fzd9
Name: frizzled class receptor 9
Synonyms: frizzled 9, mfz9, Fz9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14371
HGNC: HGNC:4047
Homologene: 2619
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Nisch
Name: nischarin
Synonyms: edsn, 3202002H23Rik, 1200007D05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Aunip
Name: aurora kinase A and ninein interacting protein
Synonyms: 2610002D18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69885
Homologene: 81895
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Shb
Name: src homology 2 domain-containing transforming protein B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230126
Homologene: 74458
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, TSP-1, Thbs-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Pebp1
Name: phosphatidylethanolamine binding protein 1
Synonyms: Pebp1, Raf-1 inhibitor protein, Pbp1, RKIP, Pbpr
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23980
HGNC: HGNC:8630
Homologene: 37637
Peg3
Name: paternally expressed 3
Synonyms: Gcap4, End4, Pw1, Zfp102
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Crcp
Name: calcitonin gene-related peptide-receptor component protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12909
Homologene: 40587
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: ca150, Fbp28, 2900090C16Rik, 2410022J09Rik, p144, Taf2s
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56070
Homologene: 4879
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: 2010013B10Rik, A230048G03Rik, D330050P16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Gkap1
Name: G kinase anchoring protein 1
Synonyms: D13Ertd340e, 4933400B15Rik, Gkap42, 42kDa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56278
VEGA: 13
Homologene: 10515
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Aadat
Name: aminoadipate aminotransferase
Synonyms: Kyat2, Kat2, mKat-2, KATII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23923
Homologene: 56540
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
Brd10
Name: bromodomain containing 10
Synonyms: Gm9832, 9930021J03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240613
Homologene: 19046
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Rp1h, mG145, oxygen-regulated protein 1, Dcdc3, Orp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76295
Homologene: 32919
Rabgap1l
Name: RAB GTPase activating protein 1-like
Synonyms: Hh1, 8430421H08Rik, 9630005B12Rik, 5830411O09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 29809
Homologene: 8143
Amigo3
Name: adhesion molecule with Ig like domain 3
Synonyms: E430002N15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320844
Homologene: 45570
Dpp7
Name: dipeptidylpeptidase 7
Synonyms: QPP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 83768
Homologene: 22748
Slc36a1
Name: solute carrier family 36 (proton/amino acid symporter), member 1
Synonyms: 5830411H19Rik, Pat1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215335
Homologene: 121860
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, Slo, MaxiK, BKCa, BK channel alpha subunit, mSlo1, Slo1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Or8j3c
Name: olfactory receptor family 8 subfamily J member 3C
Synonyms: Olfr1062, GA_x6K02T2Q125-47892992-47892045, MOR185-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259082
Homologene: 83135
Ptk2b
Name: PTK2 protein tyrosine kinase 2 beta
Synonyms: Raftk, CAKbeta, cellular adhesion kinase beta, proline-rich tyrosine kinase 2, related adhesion focal tyrosine kinase, E430023O05Rik, PYK2, calcium-dependent tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19229
HGNC: HGNC:9612
Homologene: 23001
Mpl
Name: myeloproliferative leukemia virus oncogene
Synonyms: c-mpl-II, CD110, c-mpl-I, hlb219, TPO-R, thrombopoietin receptor, c-mpl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17480
HGNC: HGNC:7217
Homologene: 7845
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Ints5
Name: integrator complex subunit 5
Synonyms: 1110055N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109077
Homologene: 35303
Pdha2
Name: pyruvate dehydrogenase E1 alpha 2
Synonyms: Pdhal
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18598
HGNC: HGNC:8807
Homologene: 137212
Or5a1
Name: olfactory receptor family 5 subfamily A member 1
Synonyms: MOR215-3, GA_x6K02T2RE5P-2479601-2478648, V5, Olfr76
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258677
HGNC: HGNC:8319
Homologene: 17342
Or6c66b
Name: olfactory receptor family 6 subfamily C member 66B
Synonyms: MOR108-2, Olfr792, GA_x6K02T2PULF-11219415-11220350
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258150
Homologene: 133881
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk2, Nsk3, MDK4, Nsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
1700067P10Rik
Name: RIKEN cDNA 1700067P10 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68224
VEGA: 17
Homologene: 87035
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: MDA-5, Helicard, 9130009C22Rik, MDA5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71586
Homologene: 32535
Amy2a1
Name: amylase 2a1
Synonyms: mAmy2-6, Amy2-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043207
Gbp11
Name: guanylate binding protein 11
Synonyms: Gm7141
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 634650
Homologene: 128731
Chit1
Name: chitinase 1
Synonyms: 2300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210035
Homologene: 18346
Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Synonyms: sterol 12-alpha-hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13124
HGNC: HGNC:2653
Homologene: 3233
Krtap4-1
Name: keratin associated protein 4-1
Synonyms: A030010K20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 665891
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332579
Homologene: 14150
Mucl1
Name: mucin-like 1
Synonyms: Spt2, Spt-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20771
Homologene: 137219
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,348,784 bp
  • T to C, chromosome 1 at 134,151,267 bp
  • A to C, chromosome 1 at 160,443,276 bp
  • G to A, chromosome 1 at 195,082,641 bp
  • T to C, chromosome 2 at 25,356,121 bp
  • T to C, chromosome 2 at 26,357,938 bp
  • T to C, chromosome 2 at 62,605,649 bp
  • T to A, chromosome 2 at 86,423,632 bp
  • C to A, chromosome 2 at 118,113,238 bp
  • A to T, chromosome 3 at 35,819,917 bp
  • A to T, chromosome 3 at 113,529,497 bp
  • C to A, chromosome 3 at 141,211,363 bp
  • A to G, chromosome 4 at 32,768,793 bp
  • A to T, chromosome 4 at 45,489,161 bp
  • T to G, chromosome 4 at 58,286,051 bp
  • T to C, chromosome 4 at 118,448,913 bp
  • T to A, chromosome 4 at 134,523,149 bp
  • T to A, chromosome 4 at 138,126,512 bp
  • C to T, chromosome 4 at 141,470,370 bp
  • T to A, chromosome 5 at 105,343,809 bp
  • A to G, chromosome 5 at 117,283,271 bp
  • A to G, chromosome 5 at 130,042,236 bp
  • T to C, chromosome 5 at 135,249,670 bp
  • T to A, chromosome 6 at 58,873,801 bp
  • A to T, chromosome 6 at 146,374,518 bp
  • T to G, chromosome 7 at 6,708,524 bp
  • C to A, chromosome 7 at 34,942,682 bp
  • T to C, chromosome 7 at 43,573,495 bp
  • T to A, chromosome 8 at 15,926,598 bp
  • A to T, chromosome 8 at 60,506,145 bp
  • C to G, chromosome 8 at 72,667,379 bp
  • A to G, chromosome 9 at 108,054,176 bp
  • T to A, chromosome 9 at 121,914,920 bp
  • A to T, chromosome 10 at 82,291,892 bp
  • T to C, chromosome 10 at 127,677,119 bp
  • T to A, chromosome 10 at 129,540,727 bp
  • T to A, chromosome 11 at 55,232,508 bp
  • C to T, chromosome 11 at 99,628,064 bp
  • G to A, chromosome 13 at 58,243,848 bp
  • A to T, chromosome 14 at 23,501,162 bp
  • A to G, chromosome 14 at 31,173,136 bp
  • A to T, chromosome 14 at 66,156,392 bp
  • T to C, chromosome 14 at 93,887,093 bp
  • T to C, chromosome 15 at 11,851,493 bp
  • A to G, chromosome 15 at 103,753,797 bp
  • G to T, chromosome 17 at 48,090,329 bp
  • A to G, chromosome 17 at 78,762,203 bp
  • A to T, chromosome 18 at 42,553,494 bp
  • T to A, chromosome 19 at 8,896,006 bp
  • C to T, chromosome 19 at 12,120,557 bp
  • T to C, chromosome 19 at 29,754,164 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8672 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068527-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.