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Strain Name:
C57BL/6J-MtgxR1587Btlr/Mmmh
Stock Number:
039624-MU
Citation ID:
RRID:MMRRC_039624-MU
Other Names:
R1587 (G1), C57BL/6J-MtgxR1587Btlr
Major Collection:

Strain Information

Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20841
Homologene: 56444
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: subtilisin/kexin isozyme-1, SKI-1, S1P, 0610038M03Rik, site-1 protease
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56453
Homologene: 2808
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 245945
Homologene: 36932
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, 3110009E13Rik, Sdccag10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: SAP90, PSD-95, SAP90A, PSD95, Dlgh4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Dnajc7
Name: DnaJ heat shock protein family (Hsp40) member C7
Synonyms: mDj11, Ttc2, mTpr2, 2010003F24Rik, 2010004G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56354
Homologene: 68306
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 10,159,959 bp
  • G to A, chromosome 1 at 59,483,006 bp
  • C to A, chromosome 1 at 110,100,027 bp
  • C to T, chromosome 2 at 13,672,605 bp
  • A to G, chromosome 2 at 66,680,852 bp
  • T to A, chromosome 2 at 88,025,133 bp
  • A to G, chromosome 2 at 91,476,305 bp
  • C to A, chromosome 2 at 118,791,583 bp
  • T to C, chromosome 2 at 160,781,693 bp
  • G to T, chromosome 2 at 165,353,517 bp
  • G to A, chromosome 3 at 90,602,311 bp
  • T to A, chromosome 3 at 123,114,398 bp
  • A to G, chromosome 4 at 11,245,722 bp
  • G to A, chromosome 4 at 56,786,666 bp
  • T to G, chromosome 4 at 115,610,534 bp
  • A to T, chromosome 4 at 119,353,176 bp
  • C to T, chromosome 4 at 155,301,026 bp
  • T to C, chromosome 4 at 156,179,440 bp
  • A to G, chromosome 5 at 66,024,991 bp
  • T to C, chromosome 5 at 110,653,023 bp
  • G to A, chromosome 5 at 110,726,902 bp
  • T to C, chromosome 5 at 139,800,145 bp
  • T to G, chromosome 6 at 47,552,490 bp
  • A to G, chromosome 6 at 91,043,741 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • G to T, chromosome 6 at 149,326,520 bp
  • G to T, chromosome 7 at 12,970,643 bp
  • A to G, chromosome 7 at 27,854,134 bp
  • T to A, chromosome 7 at 79,134,765 bp
  • A to T, chromosome 7 at 79,354,010 bp
  • A to C, chromosome 7 at 83,757,204 bp
  • A to G, chromosome 7 at 110,074,068 bp
  • G to A, chromosome 7 at 140,923,046 bp
  • A to T, chromosome 8 at 4,348,544 bp
  • A to T, chromosome 8 at 13,034,783 bp
  • G to A, chromosome 8 at 45,941,746 bp
  • T to C, chromosome 8 at 119,518,219 bp
  • T to A, chromosome 8 at 128,476,282 bp
  • A to T, chromosome 9 at 21,737,913 bp
  • C to T, chromosome 9 at 46,290,215 bp
  • A to G, chromosome 9 at 59,394,871 bp
  • T to A, chromosome 9 at 59,665,860 bp
  • A to G, chromosome 10 at 41,811,112 bp
  • T to C, chromosome 11 at 3,353,455 bp
  • T to A, chromosome 11 at 70,031,746 bp
  • T to C, chromosome 11 at 70,661,470 bp
  • A to T, chromosome 11 at 100,102,302 bp
  • A to G, chromosome 11 at 100,601,730 bp
  • G to A, chromosome 12 at 13,558,685 bp
  • C to T, chromosome 13 at 21,611,913 bp
  • C to A, chromosome 13 at 34,892,150 bp
  • A to G, chromosome 13 at 63,340,432 bp
  • T to C, chromosome 13 at 104,792,637 bp
  • A to G, chromosome 14 at 70,511,708 bp
  • A to G, chromosome 15 at 58,028,612 bp
  • A to G, chromosome 15 at 76,870,284 bp
  • T to A, chromosome 15 at 82,761,133 bp
  • C to T, chromosome 16 at 18,280,291 bp
  • T to C, chromosome 16 at 19,028,442 bp
  • T to C, chromosome 16 at 26,698,823 bp
  • T to A, chromosome 16 at 91,659,718 bp
  • A to G, chromosome 17 at 20,472,121 bp
  • A to T, chromosome 17 at 20,540,740 bp
  • T to A, chromosome 17 at 26,937,492 bp
  • A to T, chromosome 17 at 48,166,417 bp
  • T to C, chromosome 17 at 66,149,256 bp
  • G to T, chromosome 17 at 85,985,437 bp
  • T to C, chromosome 18 at 74,733,990 bp
  • T to A, chromosome 19 at 24,815,749 bp
  • C to T, chromosome 19 at 57,083,547 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1587 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039624-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.