Strain Name:
C57BL/6J-MtgxR4513Btlr/Mmmh
Stock Number:
041759-MU
Citation ID:
RRID:MMRRC_041759-MU
Other Names:
R4513 (G1), C57BL/6J-MtgxR4513Btlr
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: EGF-TM7, Ly71, F4/80, Emr1, TM7LN3, DD7A5-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap1b, Mtap5, LC1, MAP5, Mtap-5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Id3
Name: inhibitor of DNA binding 3
Synonyms: Idb3, bHLHb25, HLH462
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15903
HGNC: HGNC:5362
Homologene: 1633
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, 1200014D21Rik, NBMPR-sensitive equilibrative nucleoside transporter
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: Crk1, p38alpha, p38 MAP kinase alpha, p38MAPK, p38a, p38 MAP Kinase, p38 alpha, CSBP2, p38-alpha, Mxi2, Csbp1, p38, p38 MAPK
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Lsm12
Name: LSM12 homolog
Synonyms: 1110032E16Rik, 2600001B17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268490
Homologene: 6114
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, Mcmd, P1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A330106J01Rik, A930009A08Rik, Gpr48
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107515
Homologene: 10226
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, sam3, Fgfr-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: 0610039E24Rik, Dhrs10, retSDR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66065
Homologene: 133800
Mkln1
Name: muskelin 1, intracellular mediator containing kelch motifs
Synonyms: A130067F06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27418
HGNC: HGNC:7109
Homologene: 8305
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102075
Homologene: 18516
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Got1l1
Name: glutamic-oxaloacetic transaminase 1-like 1
Synonyms: 1700083M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76615
Homologene: 65045
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: 4921534N07Rik, 9030411M13Rik, MCT2, D630004K10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20503
Homologene: 20990
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Or5b120
Name: olfactory receptor family 5 subfamily B member 120
Synonyms: GA_x6K02T2RE5P-3834960-3835907, Olfr1477, MOR202-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258691
Homologene: 110492
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Guf1
Name: GUF1 homolog, GTPase
Synonyms: mtEF4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231279
Homologene: 6505
Cfap96
Name: cilia and flagella associated protein 96
Synonyms: 1700029J07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69479
Homologene: 45977
Rbm11
Name: RNA binding motif protein 11
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224344
HGNC: HGNC:9897
Homologene: 16988
Dnai2
Name: dynein axonemal intermediate chain 2
Synonyms: C030015H18Rik, b2b3405Clo, Dnaic2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432611
Homologene: 11311
Ppp1r18
Name: protein phosphatase 1, regulatory subunit 18
Synonyms: 2310014H01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76448
Homologene: 19512
D630003M21Rik
Name: RIKEN cDNA D630003M21 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228846
Homologene: 18598
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: 2810483F24Rik, Jnkbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26390
Homologene: 69109
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277667
Xkr7
Name: X-linked Kx blood group related 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228787
Homologene: 19390
Msh5
Name: mutS homolog 5
Synonyms: Mut5, G7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Ube2q2
Name: ubiquitin-conjugating enzyme E2Q family member 2
Synonyms: 3010021M21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109161
Homologene: 45455
Or51q1
Name: olfactory receptor family 51 subfamily Q member 1
Synonyms: MOR5-2, GA_x6K02T2PBJ9-6713641-6714588, Olfr635
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259122
Homologene: 133592
Nfkbiz
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Synonyms: Mail
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 80859
Homologene: 12734
Or1j19
Name: olfactory receptor family 1 subfamily J member 19
Synonyms: GA_x6K02T2NLDC-33481050-33481991, MOR136-8, Olfr348
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258946
HGNC: HGNC:8209
Homologene: 105219
Tle2
Name: transducin-like enhancer of split 2
Synonyms: Grg2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21886
Homologene: 20693
Sbp
Name: spermine binding protein
Synonyms: p25
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20234
Homologene: 117464
St6gal2
Name: beta galactoside alpha 2,6 sialyltransferase 2
Synonyms: ST6Gal II, C230064G14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240119
Homologene: 13052
Tmem33
Name: transmembrane protein 33
Synonyms: 2700052H22Rik, 1110006G02Rik, 1600019D15Rik, 2410089A21Rik, 5430406L04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67878
Homologene: 10018
Or51t4
Name: olfactory receptor family 51 subfamily T member 4
Synonyms: GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258357
Homologene: 27137
Cenpn
Name: centromere protein N
Synonyms: 2610510J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72155
Homologene: 12450
Gm10110
Name: predicted gene 10110
Type: Gene
Species: Mouse
Chromosome: 14
Spanxn4
Name: SPANX family, member N4
Synonyms: 1700047L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73309
VEGA: 12
Trav6-3
Name: T cell receptor alpha variable 6-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328483
Gm5908
Name: predicted gene 5908
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Homologene: 133400
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: Fam75d1d, 4932411G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238663
Homologene: 129932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,810,232 bp
  • T to C, chromosome 2 at 12,182,736 bp
  • A to G, chromosome 2 at 36,786,770 bp
  • T to C, chromosome 2 at 110,012,016 bp
  • T to A, chromosome 2 at 120,023,693 bp
  • T to C, chromosome 2 at 153,054,633 bp
  • T to C, chromosome 2 at 158,204,802 bp
  • A to G, chromosome 4 at 113,742,185 bp
  • G to T, chromosome 4 at 136,144,358 bp
  • T to C, chromosome 4 at 143,698,148 bp
  • A to G, chromosome 5 at 33,723,116 bp
  • T to C, chromosome 5 at 67,286,125 bp
  • T to C, chromosome 5 at 69,561,662 bp
  • T to C, chromosome 6 at 31,433,158 bp
  • A to T, chromosome 6 at 102,168,982 bp
  • C to T, chromosome 7 at 45,562,915 bp
  • T to C, chromosome 7 at 102,948,738 bp
  • T to C, chromosome 7 at 103,979,441 bp
  • C to T, chromosome 8 at 27,198,485 bp
  • G to T, chromosome 8 at 32,477,077 bp
  • G to T, chromosome 8 at 45,968,138 bp
  • T to A, chromosome 8 at 105,380,402 bp
  • A to G, chromosome 8 at 116,933,396 bp
  • A to C, chromosome 9 at 54,419,884 bp
  • C to A, chromosome 9 at 55,149,800 bp
  • G to A, chromosome 9 at 86,520,559 bp
  • A to G, chromosome 10 at 81,587,560 bp
  • A to G, chromosome 10 at 121,870,326 bp
  • T to G, chromosome 10 at 125,233,439 bp
  • T to C, chromosome 11 at 102,167,083 bp
  • T to C, chromosome 11 at 114,750,535 bp
  • T to C, chromosome 12 at 52,796,004 bp
  • A to T, chromosome 12 at 62,688,100 bp
  • T to C, chromosome 12 at 103,021,760 bp
  • T to C, chromosome 13 at 59,728,554 bp
  • T to A, chromosome 13 at 99,444,233 bp
  • A to T, chromosome 14 at 31,743,285 bp
  • A to G, chromosome 14 at 53,430,091 bp
  • C to G, chromosome 14 at 54,735,790 bp
  • A to G, chromosome 14 at 89,897,715 bp
  • C to T, chromosome 15 at 76,186,218 bp
  • T to C, chromosome 16 at 55,816,841 bp
  • T to C, chromosome 16 at 75,596,587 bp
  • G to A, chromosome 17 at 23,945,312 bp
  • T to C, chromosome 17 at 28,724,824 bp
  • A to T, chromosome 17 at 35,030,688 bp
  • A to G, chromosome 17 at 35,868,304 bp
  • A to C, chromosome 17 at 45,589,066 bp
  • A to T, chromosome 17 at 55,483,017 bp
  • A to G, chromosome 17 at 57,410,947 bp
  • A to G, chromosome 19 at 5,702,210 bp
  • A to T, chromosome 19 at 13,502,622 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4513 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041759-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.