Strain Name:
C57BL/6J-MtgxR6241Btlr/Mmmh
Stock Number:
044402-MU
Citation ID:
RRID:MMRRC_044402-MU
Other Names:
R6241 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22036
Homologene: 31343
Setd3
Name: SET domain containing 3
Synonyms: D12Ertd771e, 2610102I01Rik, 2610305M23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52690
Homologene: 41748
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Golga5
Name: golgin A5
Synonyms: Ret-II
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, G1-403-16, 5330419I02Rik, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Ints9
Name: integrator complex subunit 9
Synonyms: D14Ertd231e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 210925
VEGA: 14
Homologene: 10096
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218581
Homologene: 10157
Polr1d
Name: polymerase (RNA) I polypeptide D
Synonyms: 16kDa, Rpo1-3, mRPA16, 1110003G10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20018
Homologene: 22239
Gmeb1
Name: glucocorticoid modulatory element binding protein 1
Synonyms: 1110050A04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56809
HGNC: HGNC:4370
Homologene: 10647
Ablim2
Name: actin-binding LIM protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231148
Homologene: 82366
C1qtnf9
Name: C1q and tumor necrosis factor related protein 9
Synonyms: CTRP9, 9130217G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239126
Homologene: 18679
Ift81
Name: intraflagellar transport 81
Synonyms: CDV-1R, Cdv1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12589
Homologene: 7664
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70584
Homologene: 4300
Nudt9
Name: nudix hydrolase 9
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 9, 1190002C07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74167
HGNC: HGNC:8056
Homologene: 11435
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Dennd1c
Name: DENN domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Foxp2
Name: forkhead box P2
Synonyms: D0Kist7, 2810043D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114142
Homologene: 134404
Ciita
Name: class II transactivator
Synonyms: Gm9475, C2ta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12265
VEGA: 16
HGNC: HGNC:7067
Homologene: 207
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: 4930500L08Rik, D2Bwg1356e, 2810417D04Rik, Txndc13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52837
Homologene: 10901
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Ssu2
Name: ssu-2 homolog
Synonyms: D630042P16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243612
Homologene: 136556
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234353
Homologene: 87257
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Or2b4
Name: olfactory receptor family 2 subfamily B member 4
Synonyms: GA_x6K02T2PSCP-2264806-2265753, MOR256-3, Olfr124, SR1, A3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 259064
Homologene: 74266
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Or5al1
Name: olfactory receptor family 5 subfamily AL member 1
Synonyms: GA_x6K02T2Q125-47629317-47628376, MOR185-10, Olfr1042
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257941
Homologene: 133665
Itga1
Name: integrin alpha 1
Synonyms: Vla1, CD49A, E130012M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, Pla2g1br, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Krt77
Name: keratin 77
Synonyms: 4732484G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406220
Homologene: 45490
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Acsbg1
Name: acyl-CoA synthetase bubblegum family member 1
Synonyms: BG1, Bgm, Lpd, E230019G03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94180
Homologene: 9044
Rnf150
Name: ring finger protein 150
Synonyms: C030044C12Rik, A630007N06Rik, Greul5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330812
Homologene: 33783
H1f7
Name: H1.7 linker histone
Synonyms: H1fnt, H1T2, 1700026P10Rik, H1-7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70069
VEGA: 15
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22341
Homologene: 3962
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Ndst-1, Hsst, 1200015G06Rik, b2b2230Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Bbs2
Name: Bardet-Biedl syndrome 2
Synonyms: 2410125H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Mrps25
Name: mitochondrial ribosomal protein S25
Synonyms: Rpms25, 2810429N01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64658
Homologene: 11207
Or14c41
Name: olfactory receptor family 14 subfamily C member 41
Synonyms: Olfr295, MOR220-1, GA_x6K02T2NHDJ-9539243-9538314
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258850
Homologene: 115526
Mup15
Name: major urinary protein 15
Synonyms: Gm2068
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039150
Homologene: 74304
Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Synonyms: D12Ucla2, PI2, Spi1-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20701
HGNC: HGNC:8941
Homologene: 20103
Art2a
Name: ADP-ribosyltransferase 2a
Synonyms: Rt6-1, Art2a-ps, Rt-6, Rt6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11871
Traj9
Name: T cell receptor alpha joining 9
Synonyms: Gm16653
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124393
Iglv3
Name: immunoglobulin lambda variable 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404743
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 91,421,529 bp
  • G to T, chromosome 2 at 60,502,199 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to G, chromosome 2 at 86,160,036 bp
  • T to C, chromosome 2 at 129,037,381 bp
  • C to T, chromosome 2 at 134,639,505 bp
  • T to C, chromosome 2 at 135,910,174 bp
  • T to C, chromosome 3 at 83,922,164 bp
  • A to C, chromosome 3 at 127,052,748 bp
  • A to T, chromosome 4 at 61,439,613 bp
  • A to T, chromosome 4 at 132,242,377 bp
  • A to G, chromosome 4 at 132,246,013 bp
  • A to G, chromosome 5 at 35,874,897 bp
  • T to C, chromosome 5 at 104,054,285 bp
  • T to A, chromosome 5 at 117,272,197 bp
  • T to C, chromosome 5 at 122,602,351 bp
  • A to C, chromosome 5 at 137,605,234 bp
  • T to C, chromosome 5 at 142,494,942 bp
  • C to T, chromosome 5 at 147,078,723 bp
  • A to G, chromosome 6 at 15,394,762 bp
  • A to G, chromosome 6 at 92,183,838 bp
  • G to A, chromosome 6 at 112,374,820 bp
  • A to G, chromosome 6 at 121,646,829 bp
  • C to T, chromosome 7 at 28,565,265 bp
  • C to A, chromosome 7 at 86,586,037 bp
  • T to A, chromosome 7 at 101,555,245 bp
  • C to T, chromosome 7 at 125,872,834 bp
  • T to A, chromosome 8 at 43,626,096 bp
  • T to C, chromosome 8 at 54,181,254 bp
  • A to C, chromosome 8 at 67,818,139 bp
  • A to G, chromosome 8 at 82,864,464 bp
  • C to A, chromosome 8 at 94,098,235 bp
  • A to T, chromosome 9 at 54,642,662 bp
  • G to A, chromosome 9 at 107,968,734 bp
  • T to A, chromosome 12 at 102,472,473 bp
  • T to A, chromosome 12 at 103,729,256 bp
  • C to T, chromosome 12 at 108,157,855 bp
  • T to C, chromosome 13 at 42,158,370 bp
  • A to G, chromosome 13 at 99,412,246 bp
  • T to A, chromosome 13 at 100,425,661 bp
  • A to T, chromosome 13 at 108,324,119 bp
  • G to T, chromosome 13 at 114,960,137 bp
  • G to T, chromosome 14 at 54,209,433 bp
  • C to A, chromosome 14 at 60,779,620 bp
  • C to T, chromosome 14 at 64,980,210 bp
  • A to T, chromosome 15 at 79,304,392 bp
  • A to C, chromosome 15 at 98,256,771 bp
  • A to C, chromosome 15 at 101,865,553 bp
  • T to C, chromosome 16 at 10,511,903 bp
  • T to A, chromosome 16 at 19,241,218 bp
  • A to T, chromosome 16 at 96,013,874 bp
  • A to G, chromosome 17 at 37,805,541 bp
  • T to C, chromosome 17 at 57,066,272 bp
  • A to G, chromosome 18 at 20,590,217 bp
  • A to G, chromosome 18 at 60,703,829 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6241 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044402-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.