Strain Name:
C57BL/6J-MtgxR8469Btlr/Mmmh
Stock Number:
067913-MU
Citation ID:
RRID:MMRRC_067913-MU
Other Names:
R8469 (G1)
Major Collection:

Strain Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: 1700092A20Rik, FYVE-DSP1, ZFYVE10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Lrrc16, 1110037D04Rik, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Tara, Mus EST 478828, EST478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212281
Homologene: 133713
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Atg2b
Name: autophagy related 2B
Synonyms: C030004M05Rik, 2410024A21Rik, C630028L02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Spag9
Name: sperm associated antigen 9
Synonyms: 3110018C07Rik, Mapk8ip4, 4831406C20Rik, syd1, JLP, 4733401I23Rik, JIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70834
Homologene: 2954
Rcc1
Name: regulator of chromosome condensation 1
Synonyms: 4931417M11Rik, Chc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100088
HGNC: HGNC:1913
Homologene: 55567
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, Inoc1, 4632409L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
Marchf7
Name: membrane associated ring-CH-type finger 7
Synonyms: Axot, March7, Gtrgeo17
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57438
Homologene: 10753
Rrbp1
Name: ribosome binding protein 1
Synonyms: ES/130, 1700087N07Rik, mRRp47, mRRp41, mRRp15a, 5730465C04Rik, mRRp15b, mRRp16.8, mRRp10, mRRp5.4, mRRp2, mRRp1.8, p180, mRRp0
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 81910
Homologene: 68138
Pard6g
Name: par-6 family cell polarity regulator gamma
Synonyms: 2410049N21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93737
VEGA: 18
Homologene: 36487
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233057
Homologene: 138421
Ssh2
Name: slingshot protein phosphatase 2
Synonyms: SSH-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237860
Homologene: 14116
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239393
Homologene: 8385
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243914
Homologene: 16408
Abcd4
Name: ATP-binding cassette, sub-family D member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: D430033C21Rik, MDC-L, Dtgn1, C130072N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Krt2
Name: keratin 2
Synonyms: Krt2-17, Krt2e, Krt2-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Rcn2
Name: reticulocalbin 2
Synonyms: taipoxin-associated calcium binding protein 49, TCBP-49
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26611
HGNC: HGNC:9935
Homologene: 2176
Reep4
Name: receptor accessory protein 4
Synonyms: 2700029E10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72549
VEGA: 14
Homologene: 11888
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Cplx4
Name: complexin 4
Synonyms: A930004D23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225644
VEGA: 18
Homologene: 17150
Fam78a
Name: family with sequence similarity 78, member A
Synonyms: A130092J06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241303
Homologene: 14115
Prdm6
Name: PR domain containing 6
Synonyms: LOC225518, PRISM
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225518
HGNC: HGNC:9350
Homologene: 79756
Methig1
Name: methyltransferase hypoxia inducible domain containing 1
Synonyms: Mettl7a2-Higd1c, Mettl7a2Higd1c, UbiE2-Hig1-4, AB099516, UbiE-YGHL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 554292
Homologene: 128515
Pou4f3
Name: POU domain, class 4, transcription factor 3
Synonyms: Brn3c, Brn-3.1, Brn3.1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18998
HGNC: HGNC:9220
Homologene: 2023
Pcdha5
Name: protocadherin alpha 5
Synonyms: Crnr6, Cnr6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12941
HGNC: HGNC:8671
Homologene: 49565
Slc2a6
Name: solute carrier family 2 (facilitated glucose transporter), member 6
Synonyms: Glut6, F630103L12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227659
Homologene: 69236
Jmjd7
Name: jumonji domain containing 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433466
Homologene: 98398
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,229,028 bp
  • T to C, chromosome 2 at 27,024,335 bp
  • A to G, chromosome 2 at 32,069,333 bp
  • T to A, chromosome 2 at 60,234,326 bp
  • T to A, chromosome 2 at 119,379,593 bp
  • G to A, chromosome 2 at 120,030,162 bp
  • A to T, chromosome 2 at 128,658,344 bp
  • T to C, chromosome 2 at 143,989,741 bp
  • A to G, chromosome 3 at 103,058,901 bp
  • A to G, chromosome 4 at 132,334,134 bp
  • A to G, chromosome 5 at 41,821,491 bp
  • T to C, chromosome 5 at 124,736,831 bp
  • A to G, chromosome 7 at 29,845,147 bp
  • A to T, chromosome 7 at 31,067,640 bp
  • T to A, chromosome 9 at 56,045,201 bp
  • T to C, chromosome 9 at 62,771,398 bp
  • A to T, chromosome 11 at 4,531,223 bp
  • T to C, chromosome 11 at 59,128,237 bp
  • A to G, chromosome 11 at 77,449,608 bp
  • A to G, chromosome 11 at 94,091,801 bp
  • T to C, chromosome 12 at 55,739,413 bp
  • T to C, chromosome 12 at 80,193,683 bp
  • A to G, chromosome 12 at 84,612,416 bp
  • A to T, chromosome 12 at 105,637,911 bp
  • A to T, chromosome 13 at 24,112,028 bp
  • A to G, chromosome 13 at 55,277,553 bp
  • G to T, chromosome 13 at 67,621,362 bp
  • G to A, chromosome 13 at 93,706,667 bp
  • T to C, chromosome 13 at 108,860,188 bp
  • C to T, chromosome 14 at 68,606,580 bp
  • T to A, chromosome 14 at 70,545,740 bp
  • T to C, chromosome 15 at 39,872,395 bp
  • A to G, chromosome 15 at 78,967,019 bp
  • T to A, chromosome 15 at 99,947,305 bp
  • A to G, chromosome 15 at 100,353,249 bp
  • T to C, chromosome 15 at 101,816,369 bp
  • A to G, chromosome 16 at 91,055,909 bp
  • C to A, chromosome 17 at 32,492,366 bp
  • T to A, chromosome 18 at 36,961,745 bp
  • C to T, chromosome 18 at 42,395,274 bp
  • G to T, chromosome 18 at 53,464,686 bp
  • T to C, chromosome 18 at 65,957,012 bp
  • T to C, chromosome 18 at 80,047,132 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8469 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067913-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.