Strain Name:
C57BL/6J-MtgxR5130Btlr/Mmmh
Stock Number:
042718-MU
Citation ID:
RRID:MMRRC_042718-MU
Other Names:
R5130 (G1), C57BL/6J-MtgxR5130Btlr
Major Collection:

Gene Information

Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68310
Homologene: 32904
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: Eph2, sEP, sEH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Rabep1
Name: rabaptin, RAB GTPase binding effector protein 1
Synonyms: neurocrescin, RAB5 effector protein, rabaptin-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54189
Homologene: 3451
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: nucling, 2700059D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229681
Homologene: 14910
Nf2
Name: neurofibromin 2
Synonyms: schwannomin, merlin, moesin-ezrin-radixin-like protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Zfp442
Name: zinc finger protein 442
Synonyms: OTTMUSG00000015730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668923
Homologene: 136215
Cdc27
Name: cell division cycle 27
Synonyms: APC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217232
HGNC: HGNC:1728
Homologene: 960
Mlh1
Name: mutL homolog 1
Synonyms: colon cancer, nonpolyposis type 2, 1110035C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17350
HGNC: HGNC:7127
Homologene: 208
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 404710
Homologene: 26400
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Eng
Name: endoglin
Synonyms: CD105, Endo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, Mtap2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Tnrc6c
Name: trinucleotide repeat containing 6C
Synonyms: 9930033H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217351
Homologene: 23137
Baiap3
Name: BAI1-associated protein 3
Synonyms: LOC381076
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 545192
HGNC: HGNC:948
Homologene: 20844
Dhodh
Name: dihydroorotate dehydrogenase
Synonyms: 2810417D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56749
HGNC: HGNC:2867
Homologene: 1043
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69239
Homologene: 130756
Slc5a8
Name: solute carrier family 5 (iodide transporter), member 8
Synonyms: SMCT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216225
VEGA: 10
Homologene: 64832
V1rd19
Name: vomeronasal 1 receptor, D19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404287
Homologene: 104166
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: LOC380660, 8430416H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380660
Homologene: 11587
Fer1l4
Name: fer-1-like 4 (C. elegans)
Synonyms: 9130402C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74562
Homologene: 19075
Faap100
Name: Fanconi anemia core complex associated protein 100
Synonyms: 2310003H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71885
Homologene: 69394
Arhgef11
Name: Rho guanine nucleotide exchange factor (GEF) 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213498
Homologene: 11409
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19886
Homologene: 2207
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Siah3
Name: siah E3 ubiquitin protein ligase family member 3
Synonyms: LOC380918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 380918
VEGA: 14
Homologene: 54375
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 209683
Homologene: 41023
Prdm9
Name: PR domain containing 9
Synonyms: Meisetz, G1-419-29, repro7, Dsbc1, Rcr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213389
Homologene: 104139
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93883
Homologene: 87126
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Agbl5
Name: ATP/GTP binding protein-like 5
Synonyms: 9430057O19Rik, Ccp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231093
Homologene: 11053
Olfr411
Name: olfactory receptor 411
Synonyms: GA_x6K02T2P1NL-4481525-4480578, MOR255-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258704
Homologene: 74999
Olfr846
Name: olfactory receptor 846
Synonyms: GA_x6K02T2PVTD-13098546-13097608, MOR149-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258279
Olfr874
Name: olfactory receptor 874
Synonyms: GA_x6K02T2PVTD-31428850-31429782, MOR161-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258882
Homologene: 17377
Fahd1
Name: fumarylacetoacetate hydrolase domain containing 1
Synonyms: 1110025H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68636
VEGA: 17
Homologene: 6774
Vmn1r225
Name: vomeronasal 1 receptor 225
Synonyms: V1re5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171228
Cry2
Name: cryptochrome 2 (photolyase-like)
Synonyms: D130054K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Sowahb
Name: sosondowah ankyrin repeat domain family member B
Synonyms: 5730467H21Rik, Ankrd56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 78088
Homologene: 18429
Nova2
Name: NOVA alternative splicing regulator 2
Synonyms: LOC384569
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
Pcdha2
Name: protocadherin alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 353234
HGNC: HGNC:8668
Homologene: 135719
4930558K02Rik
Name: RIKEN cDNA 4930558K02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75368
Homologene: 51403
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 66,380,769 bp
  • T to C, chromosome 1 at 161,952,615 bp
  • A to G, chromosome 2 at 32,681,506 bp
  • T to C, chromosome 2 at 92,424,599 bp
  • G to T, chromosome 2 at 150,409,610 bp
  • T to A, chromosome 2 at 156,049,466 bp
  • A to G, chromosome 3 at 87,726,014 bp
  • C to A, chromosome 3 at 88,108,854 bp
  • A to T, chromosome 3 at 104,895,764 bp
  • A to T, chromosome 4 at 127,048,658 bp
  • G to A, chromosome 5 at 30,903,059 bp
  • T to A, chromosome 5 at 93,042,771 bp
  • G to T, chromosome 5 at 110,892,856 bp
  • T to C, chromosome 5 at 112,873,903 bp
  • A to T, chromosome 6 at 3,374,548 bp
  • A to T, chromosome 6 at 125,169,924 bp
  • T to C, chromosome 6 at 126,534,533 bp
  • C to T, chromosome 7 at 18,926,144 bp
  • T to A, chromosome 7 at 24,003,112 bp
  • T to C, chromosome 7 at 29,529,274 bp
  • A to T, chromosome 8 at 109,595,756 bp
  • T to A, chromosome 9 at 19,361,073 bp
  • T to A, chromosome 9 at 37,746,509 bp
  • C to A, chromosome 9 at 60,880,228 bp
  • A to G, chromosome 9 at 111,229,838 bp
  • T to A, chromosome 10 at 52,163,941 bp
  • A to T, chromosome 10 at 53,630,399 bp
  • T to A, chromosome 10 at 88,926,215 bp
  • T to C, chromosome 10 at 107,004,725 bp
  • A to T, chromosome 11 at 4,829,862 bp
  • T to A, chromosome 11 at 70,904,731 bp
  • A to T, chromosome 11 at 74,347,167 bp
  • A to G, chromosome 11 at 83,003,821 bp
  • T to C, chromosome 11 at 104,534,774 bp
  • T to A, chromosome 11 at 117,738,350 bp
  • A to G, chromosome 11 at 120,374,354 bp
  • A to T, chromosome 14 at 66,108,062 bp
  • A to T, chromosome 14 at 75,525,941 bp
  • C to A, chromosome 15 at 75,779,290 bp
  • A to G, chromosome 16 at 34,988,997 bp
  • A to T, chromosome 16 at 96,819,779 bp
  • T to C, chromosome 17 at 15,544,467 bp
  • A to G, chromosome 17 at 20,502,785 bp
  • A to G, chromosome 17 at 24,849,759 bp
  • G to T, chromosome 17 at 25,245,342 bp
  • A to C, chromosome 17 at 58,922,609 bp
  • A to T, chromosome 18 at 36,940,669 bp
  • T to A, chromosome 18 at 37,435,824 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5130 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042718-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.